Diagnóstico molecular de vírus T-linfotrópico humano (HTLV): histórico e estado da arte

  • Adele Caterino-de-Araujo Instituto Adolfo Lutz
  • Maria Gisele Gonçalves Instituto Adolfo Lutz
Palavras-chave: vírus T-linfotrópico humano (HTLV), vírus T-linfotrópico humano 1 (HTLV-1), vírus T-linfotrópico 2 (HTLV-2), Diagnóstico

Resumo

Técnicas de amplificação de ácidos nucleicos (nucleic acidamplification techniques, NAATs) que pesquisam partes do genomaproviral de vírus T-linfotrópicos humanos (human T-lymphotropicvirus, HTLVs) são importantes ferramentas para a caracterizaçãomolecular, diagnóstico e quantificação de carga proviral. No Brasil,os HTLV-1 e HTLV-2 são endêmicos, e o diagnóstico diferencial entreeles é de suma importância, uma vez que o HTLV-1 está relacionadoa doenças graves como a mielopatia associada ao HTLV-1 e aleucemia/linfoma de células T adultas, enquanto o HTLV-2 parecenão ser patogênico. Este trabalho realiza uma revisão narrativadas NAATs utilizadas ao longo dos anos na pesquisa de HTLVs;apresenta um quadro com dados de autor/ano de publicação, local derealização do trabalho, técnica empregada, genes alvo e objetivo doestudo. Outrossim, relata causas de possíveis falhas no diagnósticomolecular; apresenta novas metodologias e pesquisas sobre técnicas que mais se adequam à realidade brasileira; esclarece sobre anecessidade de se implantar o diagnóstico molecular na rede pública de saúde, tomando como base seu melhor custo-benefício paralaboratórios que dispõem de infraestrutura e pessoal capacitado.Concluindo, fornece informações úteis para a implementação depolíticas públicas de saúde dentro do âmbito do SUS, uma vez que ainfecção por HTLV-1 vem ganhando notoriedade junto ao Ministérioda Saúde do Brasil e a Organização Mundial da Saúde, por serde alta prevalência em várias partes do mundo, estar associada adoenças de alta morbidade e letalidade, carecer de cura, e só sercontrolada com medidas de prevenção da infecção que dependemdo diagnóstico.

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Publicado
2021-08-31
Como Citar
1.
Caterino-de-Araujo A, Gisele Gonçalves M. Diagnóstico molecular de vírus T-linfotrópico humano (HTLV): histórico e estado da arte. Bepa [Internet]. 31º de agosto de 2021 [citado 16º de outubro de 2021];18(212):14-2. Disponível em: https://periodicos.saude.sp.gov.br/index.php/BEPA182/article/view/37157
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