Keywords
Hepatitis C
Protease Inhibitors
Interferons
Protease Inhibitors
Interferons
How to Cite
Bersusa, A. A. S., Louvison, M. C. P., & Bonfim, J. R. de A. (2013). Treatment of adults with chronic hepatitis C virus genotype 1 with protease inhibitors (boceprevir and telaprevir or). Boletim Do Instituto De Saúde - BIS, 14(2), 221–228. Retrieved from https://periodicos.saude.sp.gov.br/bis/article/view/34136
Abstract
It presents systematic reviews and meta-analyzes, and coverage policies on the use of protease inhibitors (boceprevir and telaprevir) to treat adult patients infected with hepatitis C genotype 1, comparing the treatment of peginterferon alfa and ribavirin with peginterferon alfa ribavirin and protease inhibitor. It was shown that the addition of protease inhibitor has significant impact on the sustained virologic outcome.
References
1. Alkhouri N, Zein NN. Protease inhibitors: Silver bullets for chronic hepatitis C infection? Cleve Clin J Med [periódico na internet]. 2012 [acesso em 10 maio 2012];79 (3):213-22. Disponível em: http://www.ccjm.org/content/79/3/213.full.pdf+html [ Links ]
2. Australian Government. Department of Health and Ageing. Public Summary Documents by Meeting Boceprevir, capsule 200 mg, Victrelis® [monografia na internet]. 2011. [acesso em 10 maio 2012]. Disponível em http://www.health.gov.au/internet/main/publishing.nsf/Content/pbac-psd-boceprevir-july11 [ Links ]
3. Australian Government. Department of Health and Ageing. Public Summary Documents by Meeting. Telaprevir, tablet (film coated), 375 mg, Incivo® [monografia na internet]. 2011. [acesso em 10 maio 2012]. Disponível em: http://www.health.gov.au/internet/main/publishing.nsf/Content/pbac-psd-telaprevir-nov11 [ Links ]
4. Cammà C, Petta S, Enea M, Bruno R, Bronte F, Capursi V, et al. Cost-effectiveness of Boceprevir or Telaprevir for untreated patients with Genotype 1 chronic hepatitis C. Hepatology. 2012;56(3):850-60. [ Links ]
5. Canadian Agency for Drugs and Tecnologies in Health. Retreatment, Switching and Extended Therapy with Boceprevir and Telaprevir for Chronic Hepatitis C Infection: a review of the clinical effectiveness and safety [monografia na internet]. 2012 [acesso em 02 maio 2012]. Disponível em: http://64.26.163.205/media/pdf/htis/mar-2012/RC0327-001%20Extended%20Therapy%20Final.pdf [ Links ]
6. Cooper CL, Druyts E, Thorlund K, Nachega JB, Khoury ACEI, O’Regan C, et al. Boceprevir and telaprevir for the treatment of chronic hepatitis C genotype 1 infection: an indirect comparison meta-analysis. Ther Clin Risk Manag [periódico na internet]. 2012 [acesso em 13 nov 2012];8:105-30. Disponível em: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307664/pdf/tcrm-8-105.pdf [ Links ]
7. Dang SS, Wan WJ, Wang XF, Li YP, Li M, Jia XL, et al. Telaprevir for chronic hepatitis C with Genotype 1: a meta-analysis. Hepatogastroenterol. 2012;59(114):461-8. [ Links ]
8. Department of Health & Human Services. US Food Drug Administration. Protecting and Promotion your Health. 2011. Approval of Victrelis (boceprevir) a direct acting antiviral drug (DAA) to treat hepatitis C virus (HCV) [monografia na internet]. Silver Spring, MD; 2011. [acesso em 10 abr 2012] Disponível em: http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/ucm255413.htm [ Links ]
9. Department of Health & Human Services. US Food Drug Administration. Protecting and Promotion your Health. Approval of Incivek (telaprevir), a direct acting antiviral drug (DAA) to treat hepatitis C (HCV) [monografia na internet]. Silver Spring, MD; 2011. [acesso em 10 abr 2012]. Disponível em: http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/ucm256328.htm [ Links ]
10. Lee LY, Tong CYW, T. Wilkinson WM. New therapies for chronic hepatitis C infection: a systematic review of evidence from clinical trials. Int J Clin Pract. 2012;66(4):342-55. [ Links ]
11. Ministério da Saúde. Protocolo clínico e diretrizes terapêuticas para hepatite viral C e coinfecções [monografia na internet]. Brasília (DF); 2011. [acesso em 9 maio 2012]. Disponível em: http://www.aids.gov.br/sites/default/files/anexos/publicacao/2011/49960/protocolo_hepatitec_marc_pdf_29595.pdf [ Links ]
12.Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Inibidores de protease (Boceprevir e Telaprevir) para o tratamento da Hepatite C crônica. Relatório de recomendação da Comissão Nacional de Incorporação de Tecnologias no SUS – CONITEC-01 [monografia na internet]. Brasília (DF); 2012. [acesso em 13 nov 2012]. Disponível em: http://portal.saude.gov.br/portal/arquivos/pdf/Rel_IP_Hepatite_C_final.pdf [ Links ]
13. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância Epidemiológica. Hepatites virais: o Brasil está atento [monografia na internet]. 3 ed. Brasília (DF); 2008. [acesso em 9 maio 2012]. Disponível em: http://portal.saude.gov.br/portal/arquivos/pdf/brasil_atento_3web.pdf [ Links ]
14. National Institute for Health and Clinical Excellence. NICE publishes final draft guidance on telaprevir for chronic hepatitis C [monografia na internet]. 2012 [acesso em 12 abr 2012]. Disponível em: http://www.nice.org.uk/newsroom/pressreleases/FinalDraftTelaprevirHepC.jsp [ Links ]
15. Ramachandran P, Fraser A, Agarwal K, Austin A, Brown A, Foster GR, et al. UK consensus guidelines for the use of the protease inhibitors boceprevir and telaprevir in genotype 1 chronic hepatitis C infected patients. Aliment Pharmacol Ther. 2012;35(6):647-62. [ Links ]
16. Romano KP, Ali A, Aydin C, Soumana D, Ozen A, Deveau LM, et al. The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors. PLoS Pathog [periódico na internet]. 2012 [acesso em 6 nov 2012];8(7). Disponível em: http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002832 [ Links ]
17. Shiffman ML, Esteban R. Triple therapy for HCV genotype 1 infection: telaprevir or boceprevir? Liver Int [periódico na internet]. 2012 [acesso em 13 nov 2012];32(Suppl1):54-60. Disponível em: http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02718.x/pdf [ Links ]
18. Tungol A, Rademacher K, Schafer JA. Formulary management of the protease inhibitors Boceprevir and Telaprevir for chronic hepatitis C virus. J Manag Care Pharm [periódico na internet]. 2012 [acesso em 10 maio 2012];17(9):685-94.. Disponível em http://www.amcp.org/WorkArea/DownloadAsset.aspx?id=13668 [ Links ]
2. Australian Government. Department of Health and Ageing. Public Summary Documents by Meeting Boceprevir, capsule 200 mg, Victrelis® [monografia na internet]. 2011. [acesso em 10 maio 2012]. Disponível em http://www.health.gov.au/internet/main/publishing.nsf/Content/pbac-psd-boceprevir-july11 [ Links ]
3. Australian Government. Department of Health and Ageing. Public Summary Documents by Meeting. Telaprevir, tablet (film coated), 375 mg, Incivo® [monografia na internet]. 2011. [acesso em 10 maio 2012]. Disponível em: http://www.health.gov.au/internet/main/publishing.nsf/Content/pbac-psd-telaprevir-nov11 [ Links ]
4. Cammà C, Petta S, Enea M, Bruno R, Bronte F, Capursi V, et al. Cost-effectiveness of Boceprevir or Telaprevir for untreated patients with Genotype 1 chronic hepatitis C. Hepatology. 2012;56(3):850-60. [ Links ]
5. Canadian Agency for Drugs and Tecnologies in Health. Retreatment, Switching and Extended Therapy with Boceprevir and Telaprevir for Chronic Hepatitis C Infection: a review of the clinical effectiveness and safety [monografia na internet]. 2012 [acesso em 02 maio 2012]. Disponível em: http://64.26.163.205/media/pdf/htis/mar-2012/RC0327-001%20Extended%20Therapy%20Final.pdf [ Links ]
6. Cooper CL, Druyts E, Thorlund K, Nachega JB, Khoury ACEI, O’Regan C, et al. Boceprevir and telaprevir for the treatment of chronic hepatitis C genotype 1 infection: an indirect comparison meta-analysis. Ther Clin Risk Manag [periódico na internet]. 2012 [acesso em 13 nov 2012];8:105-30. Disponível em: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307664/pdf/tcrm-8-105.pdf [ Links ]
7. Dang SS, Wan WJ, Wang XF, Li YP, Li M, Jia XL, et al. Telaprevir for chronic hepatitis C with Genotype 1: a meta-analysis. Hepatogastroenterol. 2012;59(114):461-8. [ Links ]
8. Department of Health & Human Services. US Food Drug Administration. Protecting and Promotion your Health. 2011. Approval of Victrelis (boceprevir) a direct acting antiviral drug (DAA) to treat hepatitis C virus (HCV) [monografia na internet]. Silver Spring, MD; 2011. [acesso em 10 abr 2012] Disponível em: http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/ucm255413.htm [ Links ]
9. Department of Health & Human Services. US Food Drug Administration. Protecting and Promotion your Health. Approval of Incivek (telaprevir), a direct acting antiviral drug (DAA) to treat hepatitis C (HCV) [monografia na internet]. Silver Spring, MD; 2011. [acesso em 10 abr 2012]. Disponível em: http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/ucm256328.htm [ Links ]
10. Lee LY, Tong CYW, T. Wilkinson WM. New therapies for chronic hepatitis C infection: a systematic review of evidence from clinical trials. Int J Clin Pract. 2012;66(4):342-55. [ Links ]
11. Ministério da Saúde. Protocolo clínico e diretrizes terapêuticas para hepatite viral C e coinfecções [monografia na internet]. Brasília (DF); 2011. [acesso em 9 maio 2012]. Disponível em: http://www.aids.gov.br/sites/default/files/anexos/publicacao/2011/49960/protocolo_hepatitec_marc_pdf_29595.pdf [ Links ]
12.Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Inibidores de protease (Boceprevir e Telaprevir) para o tratamento da Hepatite C crônica. Relatório de recomendação da Comissão Nacional de Incorporação de Tecnologias no SUS – CONITEC-01 [monografia na internet]. Brasília (DF); 2012. [acesso em 13 nov 2012]. Disponível em: http://portal.saude.gov.br/portal/arquivos/pdf/Rel_IP_Hepatite_C_final.pdf [ Links ]
13. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância Epidemiológica. Hepatites virais: o Brasil está atento [monografia na internet]. 3 ed. Brasília (DF); 2008. [acesso em 9 maio 2012]. Disponível em: http://portal.saude.gov.br/portal/arquivos/pdf/brasil_atento_3web.pdf [ Links ]
14. National Institute for Health and Clinical Excellence. NICE publishes final draft guidance on telaprevir for chronic hepatitis C [monografia na internet]. 2012 [acesso em 12 abr 2012]. Disponível em: http://www.nice.org.uk/newsroom/pressreleases/FinalDraftTelaprevirHepC.jsp [ Links ]
15. Ramachandran P, Fraser A, Agarwal K, Austin A, Brown A, Foster GR, et al. UK consensus guidelines for the use of the protease inhibitors boceprevir and telaprevir in genotype 1 chronic hepatitis C infected patients. Aliment Pharmacol Ther. 2012;35(6):647-62. [ Links ]
16. Romano KP, Ali A, Aydin C, Soumana D, Ozen A, Deveau LM, et al. The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors. PLoS Pathog [periódico na internet]. 2012 [acesso em 6 nov 2012];8(7). Disponível em: http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1002832 [ Links ]
17. Shiffman ML, Esteban R. Triple therapy for HCV genotype 1 infection: telaprevir or boceprevir? Liver Int [periódico na internet]. 2012 [acesso em 13 nov 2012];32(Suppl1):54-60. Disponível em: http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02718.x/pdf [ Links ]
18. Tungol A, Rademacher K, Schafer JA. Formulary management of the protease inhibitors Boceprevir and Telaprevir for chronic hepatitis C virus. J Manag Care Pharm [periódico na internet]. 2012 [acesso em 10 maio 2012];17(9):685-94.. Disponível em http://www.amcp.org/WorkArea/DownloadAsset.aspx?id=13668 [ Links ]
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2013 Ana Aparecida Sanches Bersusa, Marilia Cristina Prado Louvison, José Ruben de Alcântara Bonfim
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