Abstract
Identify the effects of intra uterine exposure to cocaine, in the form of crack, associated or not with the use of other drugs of abuse in newborns. Retrospective study, conducted through information obtained from medical records of 85 neonates born in a philanthropic hospital in São Paulo, mothers who reported crack use during pregnancy. The results showed that 51 infants (60%) had gestational age at term and preterm 38%. Most mothers had syphilis 54.2%, 13.3% HIV and syphilis and 7.2% only HIV. These high rates of infection in this population calls attention, increasing chances for developmental problems due to exposure of the fetus. 1% had abnormal head circumference (microcephaly) and 1% died shortly after birth. All newborn have large periods of postpartum hospitalization (26.5 ± 1.9 days). These data together show that mothers who reported having used crack during pregnancy resonated with negative consequences for newborns.
References
nascido: guia para os profissionais de saúde. Brasília: Ministério da Saúde; 2011. (Série A. Normas e Manuais Técnicas).
2. Corrêa RRM, Salge AKM, Ribeiro GA, Ferraz MLF, Reis MA, Castro ECC, et al. Alterações anatomopatológicas da placenta e variações do índice de
Apgar. Rev Bras Saúde Mater Infant. 2006; 6(2):239-243.
3. Garcia-Bournissen F, Rokach B, Karaskov T, Koren G. Cocaine Detection in Maternal and Neonatal Hair: implications to Fetal Toxicology. Ther Drug
Monit. 2007; 29(1):71-76.
4. Giusti J, Mitsuhiro SS, Zilberman ML. Gestação e Cocaína [artigo na internet]. Associação Brasileira de Psiquiatria. Rio de Janeiro; 2006. [acesso em:
04 mai 2015]. Disponível em: http://www.abpbrasil.org.br/departamentos/coordenadores/coordenador/noticias/?dep=4¬=136.
5. Gouin K, Murphy K, Shah PS. Effects of cocaine use during pregnancy on low birthweight and preterm birth:systematic review and metaanalyses.
Am J Obstet Gynecol.2011; 204(4):340.
6. Guinsburg R, Santos AMN. Critérios diagnósticos e tratamento da sífilis congênita. São Paulo: Sociedade Brasileira de Pediatria; 2010.
7. Guyton AC, Hall JE. Gravidez e lactação. In: ______. Tratado de Fisiologia Médica. 12. ed. Rio de Janeiro: Elsevier;2011. p.1059-1073.
8. Jones HE, Berkman ND, Kline TL, Ellerson RM, Browner FA, Poulton W et al. Initial feasibility of a woman-focused intervention for pregnant African-
American women. Int J Pediatr. 2011; 2011:389285.
9. Kassada DS, Marcon SS, Pagliarini MA, Rossi RM. Prevalência do uso de drogas de abuso por gestante. Acta Paul Enferm. 2013: 26(5):467-471.
10. Keller RW Jr, Snyder-Keller A. Prenatal cocaine exposure. Ann N Y Acad Sci. 2000; 909:217-232.
11. Kuczkowski KM. The effects of drug abuse on pregnancy. Curr Opin Obstet Gynecol. 2007; 19(6):578-585.
12. Lemos T. Neurobiologia da Ação da Cocaína [artigo na internet]. Associação Brasileira de Psiquiatria. Rio de Janeiro; 2006. [acesso em: 09 abr
2015]. Disponível em: http://www.abpbrasil.org.br/departamentos/coordenadores/coordenador/noticias/?not=134&dep=62.
13. Martins-Costa SH, Vettorazzi J, Cecin GKG, Maluf JMRA, Stumpf CC, Ramos JGL. Crack: a nova epidemia obstétrica. Rev HCPA. 2013; 33(1):55-65.
14. Montenegro CAB, Rezende Filho J. Trocas Materno-ovulares. In: Rezende M. Obstetrícia fundamental. 13.ed. Rio de Janeiro: Guanabara Koogan;
2014. p.88-100.
15. Oyelese Y, Ananth CV. Placenta l Abruption. Obst and Gynecol. 2006; 108(4):1005-1015.
16. Rang HP, Dale MM, Ritter JM, Moore PK. Estimulantes do SNC e psicomiméticos. In: ______. Farmacologia. 7. ed. Rio de Janeiro: Elsevier; 2011. p.584-
591.
17. Richardson GA, Goldschmidt L, Willford J. The effects of prenatal cocaine use on infant development. Neurotoxicol Teratol. 2008; 30(2):96-106.
18. Rotta NT, Cunha GB. Prenatal exposure to cocaine:review of the neurobehavioral effects. J Pediatr. 2000;76(3):179-184.
19. United Nations Office on Drugs and Crime (UNODC). World drug report 2013. New York: United Nations; 2013.151p.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2016 Alessandra Costa Timoteo, Gislaine Eiko Kuahara Camiá, Cristiane Lopes