Keywords
Incidence
Mortality
Hospitalization
Meta-analysis.
How to Cite
Abstract
Objective: To estimate the incidence of influenza-associated hospitalizations and deaths in Brazil from 2010 to 2016. Method: Records of hospital discharges and deaths (mortality system) were used by ICD codes J09-J18, data from laboratory influenza surveillance, and census population projections adjusted by the percentage of those using public health services. Meta-analysis was performed to determine the incidences of hospitalizations and deaths by age group in the five geographic regions of Brazil. Results: The estimates were 645,661 hospitalizations and 160,089 deaths from influenza from 2010 to 2016. The highest incidences of hospitalization occurred in older adults with ≥65 years (258.6/100.000) and children <5 years old (180.1/100,000), while deaths stood
out among individuals aged ≥65 (142.9/100,000) and aged 50 to 64 years (22.1/100,000). Regional differences were found, with
higher incidences predominantly in the Midwest, Southeast, and South regions. Conclusion: The burden of influenza in Brazil is of
concern, with a high number of hospitalizations and deaths from the disease. Regional and age group differences provide evidence
to support vaccination policy and the improvement of the influenza surveillance system.
References
World Health Organization – WHO. Pandemic (H1N1) 2009: update 112. World Health Organization; 2015.
Iuliano AD, Roguski KM, Chang HH, Muscatello DJ, Palekar R, Tempia S, et al. Estimates of global seasonal influenza-associated respiratory mortality: a modelling study. The Lancet. 2018;391(10127):1285–300.
Javanian M, Barary M, Ghebrehewet S, Koppolu V, Vasigala VKR, Ebrahimpour S. A brief review of influenza virus infection. Journal of Medical Virology. 2021;93(8):4638–46.
World Health Organization. (2012). Vaccines against influenza WHO position paper — November 2012 = Note de synthèsede l’OMS concernant les vaccins antigrippaux — novembre 2012. Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire, 87 (47), 461 - 476. https://apps.who.int/iris/handle/10665/241993
World Health Organization – WHO. Global Epidemiological Surveillance Standards for Influenza. Igarss. 2014;(1):1–5.
Hammond A, Cozza V, Hirve S, Medina M-J, Pereyaslov D, Zhang W. Leveraging Global Influenza Surveillance and Response System for the COVID-19 Pandemic Response and Beyond. China CDC Wkly [internet]. 2021 [acesso em 10 nov 2021];3(44):937–40. Disponível em: http://weekly.chinacdc.
cn/en/article/doi/10.46234/ccdcw2021.226
Larrauri A, Prosenc Trilar K. Preparing for an influenza season
/22 with a likely co-circulation of influenza virus and SARS-CoV-2. Eurosurveillance. 2021;26(41):2100975.
Freitas FTM, Souza LRO, Azziz-Baumgartner E, Cheng PY, Zhou H, Widdowson MA, et al. Influenza-associated excess mortality in southern Brazil, 1980-2008. Epidemiology and infection. 2013;141(8):1731–40.
Freitas ARR, Francisco PMSB, Donalisio MR. Mortality associated with influenza in tropics, state of Scenterão Paulo, Brazil, from 2002 to 2011: the pre-pandemic, pandemic, and post-pandemic periods. Influenza research and treatment. 2013:696274.
Descalzo MA, Clara W, Guzmán G, Mena R, Armero J, Lara B, et al. Estimating the burden of influenza-associated hospitalizations and deaths in Central America. Influenza and other Respiratory Viruses. 2016;10(4):340–5.
Ministério da Saúde (BR). SIHD Sistema de Informação Hospitalar Descentralizado [internet]. 2021 [acesso em 7 out 2021]. Disponível em: http://www2.datasus.gov.br/SIHD/institucional
Ministério da Saúde (BR). Sistema de Informações Sobre Mortalidade (SIM). [internet]. 2021 [acesso em 7 out 2021]. Disponível em: https://www.gov.br/saude/pt-br/composicao/vigilancia-em-saude-svs/sistemas-de-informacao/sistema-de-informacoes-sobre-mortalidade-sim
Ministério da Saúde (BR). SINAN - Sistema de Informação de Agravos de Notificação [internet]. 2016 [acesso em 6 out 2021]. Disponível em: http://portalsinan.saude.gov.br/sinan-influenza
Instituto Brasileiro de Geografia e Estatística – IBGE. Projeções da população do Brasil e unidades da federação por sexo e idade: 2010-2060. IBGE; 2018.
Ministério da Saúde (BR). Pesquisa Nacional de Saúde 2013: acesso e utilização dos serviços de saúde, acidentes e violências. Instituto Brasileiro de Geografia e Estatística; 2011. v.39
Stata Statistical Sof t ware: Release 12. College Station, TX; 2011.
Ministério da Saúde (BR). Protocolo de Tratamento de Influenza Protocolo de Tratamento de Influenza. Secretaria de Vigilância em Saúde. Brasília (DF);2013.
Ministério da Saúde (BR). Boletim Epidemiológico de Influenza: monitoramento até a semana epidemiológica 52 de 2015. Brasília (DF);2016.
Ministério da Saúde (BR). Boletim Epidemiológico de Influenza: monitoramento até a semana epidemiológica 53 de 2014. Brasília (DF); 2015.
Ministério da Saúde (BR). Boletim Epidemiológico de Influenza: monitoramento até a semana epidemiológica 52 de 2013. Brasília (DF);2014.
Ministério da Saúde (BR). Boletim Informativo de Influenza: semana epidemiológica 52 de 2012. Brasília (DF); 2013.
Ministério da Saúde (BR). Informe Técnico de Influenza, 2009, 2010 e 2011 [internet]. 2012 [acesso em 15 abr 2019]. Disponível em: http://portalarquivos2.saude.gov.br/images/pdf/2014/maio/22/informe-influenza-2009-2010-2011-220514.pdf
Ministério da Saúde (BR). Informe Epidemiológico de Influenza: monitoramento até a semana epidemiológica 52 de 2016. Brasília (DF);2017.
Ministério da Saúde (BR). CNES - Estabelecimentos por tipo, BRASIL [internet]. 2019 [acesso em 15 abr 2019]. Disponível em: http://tabnet.datasus.gov.br/cgi/tabcgi.exe?cnes/cnv/estabbr.def
Saborio GG, Clara A, Garcia A, Quesada F, Palekar R, Minaya P, et al. Influenza-associated Hospitalizations and Deaths, Costa Rica, 2009-2012. Emerg Infect Dis. 2014;20(5):878–81.
Sotomayor V, Fasce RA, Vergara N, De la Fuente F, Loayza S, Palekar R. Estimating the burden of influenza-associated hospitalizations and deaths in Chile during 2012-2014. Influenza and other Respiratory Viruses. 2018;12(1):138–45.
Uyeki TM. High-risk Groups for Influenza Complications. JAMA - Journal of the American Medical Association. 2020;324(22):2334.
Schanzer DL, Saboui M, Lee L, Nwosu A, Bancej C. Burden of influenza, respiratory syncytial virus, and other respiratory viruses and the completeness of respiratory viral identification among respiratory inpatients, Canada, 2003-2014. Influenza and other Respiratory Viruses. 2018;12(1):113–21.
Wong PL, Sii HL, P’ng CK, Ee SS, Yong Oong X, Ng KT, et al. The effects of age on clinical characteristics, hospitalization, and mortality of patients with influenza-related illness at a tertiary care centre in Malaysia. Influenza and other Respiratory Viruses. 2020;14(3):286–93.
Oliva J, Delgado-Sanz C, Larrauri A, Gallardo V, Navarro JM, Marco E, et al. Estimating the burden of seasonal influenza in Spain from surveillance of mild and severe influenza disease, 2010-2016. Influenza and other Respiratory Viruses. 2018;12(1):161–70.
Ministério da Saúde (BR), Secretaria de Vigilância em Saúde. Departamento de Imunização e Vigilância de Doenças Transmissíveis. Informe Técnico: 23ª Campanha Nacional de Vacinação Contra a Influenza Brasília (DF); 2021.
Jaakkola K, Saukkoriipi A, Jokelainen J, Juvonen R, Kauppila J, Vainio O, et al. Decline in temperature and humidity increases the occurrence of influenza in a to correct cold, climate. Environmental Health: A Global Access Science Source. 2014;13(1):1–8.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2023 Francisco José de Paula Júnior, Miguel Angel Descalzo, Jorge Jara, Erica Tatiane da Silva