Abstract
The Red Reflex Test (RRT), known in Brazil as “Exame do Olhinho”, is a neonatal screening tool for early detection of severe ocular diseases such as congenital cataract, congenital glaucoma, and retinoblastoma. Despite being legally mandatory in São Paulo, structural and organizational barriers hindered its effective implementation. In 2015, six university hospitals in partnership with the State Health Department established the “Care pathway for children with abnormal Red Reflex Test,” funded by PPSUS. The model structured a three-level flow: maternity hospitals, regional re-testing centers, and specialized reference centers. Electronic scheduling through the CROSS system and the 15-day deadline ensured timely diagnosis and treatment. In 2016, Resolution nº 19 institutionalized a statewide protocol for diagnosis, treatment, and follow-up of children with abnormal RRT, requiring mandatory continuity of care across the health system. This initiative strengthened integration among research, management, and care, representing a significant step in preventing childhood blindness in São Paulo.
References
1. Pon JA, Bevin TH, Herbison P, Taylor BJ, Sanderson G. A novel instrument for assessing the retinal red reflex for non-ophthalmic health professionals. Clin Exp Optom. 2005;88(3):160-4.
2. Red reflex examination in infants. Section on Ophthalmology. American Academy of Pediatrics. Pediatrics. 2002;109(5):980-1.
3. Eye examination in infants, children, and young adults by pediatricians. Committee on Practice and Ambulatory Medicine and Section on Ophthalmology. American Association of Certified Orthoptists; American Association for Pediatric Ophthalmology and Strabismus; American Academy of Ophthalmology. Pediatrics. 2003;111(4):902-7.
4. Meier P, Sterker I, Tegetmeyer H. Leucocoria in childhood. Klin Monbl Augenheilkd. 2006;223(6):521-7.
5. Duke-Elder S, editor. System of ophthalmology. Congenital deformaties. St Louis: Mosby; 1969. v. 3, pt. 2.
6. Rodrigues ACL, Prado RB, Miguel L. Implantação do exame do reflexo vermelho em crianças da região do Hospital das Clínicas da Faculdade de Medicina de Botucatu - SP - Brasil. Arq. Bras. Oftalmol. 2012; 75(5): 337-340.

This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2025 Antonio Carlos Lottelli, Carmela Maggiuzzo Grindler