Enzimas em biologia molecular. III. Tecnologia CRISPR-Cas9

Doudna JA, Charpentier E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science. 2014; 346(6213):1258096. doi: 10.1126/ science.1258096

Wang M, Glass ZA, Xu Q. Non-viral delivery of genome-editing nucleases for gene therapy. Gene Ther. 2017; 24(3):144-50.

Kennedy EM, Cullen BR. Gene editing: a new tool for viral disease. Annu Rev Med. 2017; 68:401-11.

Yin H, Kauffman KJ, Anderson DG. Delivery technologies for genome editing. Nat Rev Drug Discov. 2017; 16(6):387-99.

Jinek M, Chylinsky K, Fonfara I, Hauer M, Doudna JA, Charpentier E. A programmable dual-RNA–guided DNA endonuclease in adaptative bacterial immunity. Science. 2012; 337(6096): 816-21.

Mojica FJM, Díez-Villaseñor, C, García-Martínez J, Almendros C. Short motif sequences determine the targets of the prokaryotic CRISPR defence system. Microbiology. 2009; 155(Pt 3): 733-40.

Comfort N. Genome Editing: That’s the way the CRISPR crumbles. Nature. 2017; 546(7656):30-1