Methylphenidate in the treatment of attention deficit disorder and hyperactivity in children and adolescents
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Keywords

Methylphenidate
Attention Deficit Hyperactivity Disorder
Children and Adolescents

How to Cite

Venancio, S. I., Paiva, R. de, Toma, T. S., & Bonfim, J. R. de A. (2013). Methylphenidate in the treatment of attention deficit disorder and hyperactivity in children and adolescents. Boletim Do Instituto De Saúde - BIS, 14(2), 237–246. Retrieved from https://periodicos.saude.sp.gov.br/bis/article/view/34138

Abstract

Methylphenidate is a central nervous system stimulant with more prominent effects on mental activity than in motor activity. The mode of action is not fully known, but a key action seems to be the inhibition of dopamine transport. It is indicated as part of a comprehensive program of treatment of attention deficit disorder and hyperactivity (ADHD), which should include psychological, educational and social measures, in adults and children above 6 years of age. This review assessed the efficacy and safety of methylphenidate in the treatment of children and adolescents diagnosed with ADHD. Search of bibliographic resources was carried out in December 2012 in the database Center for Reviews and Dissemination (CRD), in order to identify releases of Health Technology Assessment. From 54 entries, three were selected for analysis. After analysis of these documents was held search for randomized controlled trials in EMBASE and PubMed databases, published 1 June 2010 to 22 February 2013, but none were selected for analysis. Evidence points behavioral therapies as first choice in the treatment of ADHD in children up to 6 years old. Above this age methylphenidate is indicated as drug of choice and should be considered an association with behavioral therapies, especially for children up to twelve years.

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References

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I Bula de Ritalina (cloridrato de metilfenidato, Novartis). [acesso em 15 de dezembro de 2012. Disponível em http://www4.anvisa.gov.br/base/visadoc/BM/BM%5B26162-1-0%5D.PDF
II National Guideline Clearinghouse é uma iniciativa da Agency for Healthcare Research and Quality, dos Estados Unidos; http://guideline.gov/index.aspx
III O sistema GRADE (Grading of Recommendations Assessment, Development and Evolution) classifica as recomendaçoes como fortes ou fracas e é utilizado como referência por diversas agências de regulação de saúde (www.gradingworkinggroup.org). A qualidade das provas é apresentada pelas letras A (alta qualidade), B (moderada), C (baixa) e D (muito baixa). A força da recomendação é de 1 (forte) a 2 (fraca).
IV Informação obtida da Lista de fármacos para solicitação de elaboração de parecer técnico científico, da CCTIES/SES-SP.21/11/2012
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2013 Sonia Isoyama Venancio, Rui de Paiva, Tereza Setsuko Toma, José Ruben de Alcântara Bonfim

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