Eritema nodoso hansênico: análise comparativa do quadro histopatológico pelas técnicas de rotina e imunofluorescência
DOI:
https://doi.org/10.47878/hi.1995.v20.35446Keywords:
Erythema nodosum leprosum, Leprosy, lmmunocomplex, Immunofluorescence, VasculitisAbstract
To investigate the role of immunecomplexes (Ic) in type 2 reaction (ENL), tissue fragments of 22 reactional leprosy patients were studied by means of direct immunofluorescence techinique (DIF) in association to routine histopathology. Results showed immunecomplexes in vessel and in the membrance of the dermal-epidermal junction (BMZ). The presence of lc in the deep dermal vessels and in subcutaneous tissue in connection to necrotizing vasculits alteration suggest the participation of these complexes in type 2 reaction (ENL)
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Botucatu, UNESP.
3. BULLOCK, W.E.; CALLERME, M.L.; PANNER, B.J. Immunohistologic alteration of skin and ultrastructural changes of glomerular
basement membranes in leprosy. Am. j. trop. med. Hyg., v. 23, p. 81-6. 1974.
4. CASTRO, A.M. Contribuição ao estudo clínico da reção leprótica. Rev. bras. Leprol., v. 11, p. 23-54, 1953.
5 - CONGRESSO INTERNACIONAL DE LEPROLOGIA, 6. Madrid, Associacion Internacional de la lepra, 1953.
6 - FARACO, J. Bacillos de Hansen e cortes de parafina: méthodo complementar para pesquisa de bacillos de Hansen em cortesde material incluído em parafina. Rev. bras. LeproL, v. 6, p. 177-80, 1938.
7. FITE, G.L. Staining of acid-fast bacilli in paraf in sections. Am. j. Path., v. 14, p. 491-507, 1938.
8. GOLDMAN, M. Fluorescent antibody methods. New York, Academic Press, 1968, 103 p.
9. GOWER, R.G.; MITCHEL, S.; THORNE, E.G.; K O H L E R , P . F . ; C L A M A N , H . N . Leucocytoclastic vasculities: sequential appearence of immunoreactants and cellular changes in serial biopsies. J. inv. Derm., vol. 69, p. 477-84, 1977.
10. HASTINGS, R.C. Leprosy. Edinburgh, Churchill Levingstone, 1985. 331 p.
11. LILLIE, R.D. Histophatologic technic and pratical histochemistry, 22 ed. New York, Blakinston, 1954, p. 114-5.
12. LONDONO, F.; PATARROYO, M.E.; RUEDA, M.M.D.; MEN ESES, A. Erythema nodosum leprosum. Arch. derm., v. 113, p. 234-5, 1977.
13. MALABAY, M.C.; HELWIG, E.B.;TOLENTINO, J.G.; BINFRD, C.H. The histophatology and histochemistry of erythema nodosum
leprosum. Int j. Leprosy, vol. 33, p. 28-49, 1965.
14. NAAFS, B.; KOLK, A.H.J.; LIEN, R.A.M.; FABER, W.R.; VAN DIJK, G.; VAN JOOST, T. Mycobacterium Leprae monoclonal antibodies cross-react with skin: An alternative response in leprosy. J. inv. Derm., vol. 94, p. 685-88, 1990.
15. NAAFS, B. Leprosy reactions. Trop. geogr. Medicine, vol. 46, p. 80-4, 1994.
16. OPROMOLLA, D.V.A. & FLEURY, R.N. Noções de hansenologia. In: Centro de Estudos "Dr. Reynaldo Quagliato". Baum: Instituto
Lauro de Souza Lima, 1980, 84-96.
17. QUISMORIO, F.P.; REA, T.; LEVAN, N.; FRIOU, G. Immunoglobulin deposits in lepromatous leprosy. Arch. derm., vol. 111, p. 331-34, 1975.
18. RATH DE SOUZA, P. Estrutura histológica; outros dados laboratoriais; bacterioscopia. Bal. Serv. Nac. Lepra, vol. 15, p. 26-9, 1956. (n° especial).
19. REA, T.H. & LEVAN, N.E. Erythema nodosum leprosum in a General Hospital.Arch. Derm., vol. 111, p. 575-80, 1975.
20. RIDLEY, M.J. & RIDLEY, D.S. The immunopathology of erythema nodosum leprosum: the role of extravascular complexes. Leprosy Rev., vol. 54, p. 95107, 1983.
21. WADE, H.W. The nature of erythema nodosum type of reaction lesion in lepromatous leprosy, with special reference to affects of r e pet e ad r e ac t io ns . I n: Co n gr es s International of Leprosy., 6. Madrid. 1953, Memória. Madrid. Madrid, 1953, p. 725-9.
22. WATERS, M.F.R.; TURK, J.L.; WEMAMBU, S.N.C. Mechanisms of reaction in leprosy. Int. j. Leprosy, vol. 39, p. 417-28, 1971.
23. WEMAMBU, S.N.C.; TURK, J.L.; WATERS, M. F.R.; REES, R.J.W. Eryhema nodosum leprosum: clinical manifestation of the Arthus
phenomenon.Lancet, vol.2, p.933-5, 1969.
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Published
1995-06-30
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1.
Nogueira MES, Fleury RN, Arruda MSP. Eritema nodoso hansênico: análise comparativa do quadro histopatológico pelas técnicas de rotina e imunofluorescência. Hansen. Int. [Internet]. 1995 Jun. 30 [cited 2024 May 18];20(1):11-8. Available from: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35446
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