Múltiplos efeitos da pandemia de Covid-19 no contexto do transplante de órgãos no Brasil e no mundo

Autores

DOI:

https://doi.org/10.57148/bepa.2023.v.20.39591

Palavras-chave:

covid-19, obtenção de tecidos e órgãos, impacto

Resumo

Introdução: Este artigo apresenta uma revisão literária do impacto dos transplantes de órgãos no contexto da pandemia de Covid-19. Esse período gerou desafios significativos para os programas de transplantes em todo o mundo, afetando a disponibilidade de órgãos, a segurança dos receptores, dos doadores e de recursos médicos. Objetivos: Realizar um levantamento dos aspectos relacionados aos impactos da pandemia de Covid-19 em torno do processo de transplantes. Método: Foi feita uma revisão sistemática com busca de artigos nas bases do PubMed, SciELO e LILACS, março de 2020 a fevereiro de 2023. Os descritores foram utilizados de forma combinada: “Covid-19”, “Transplante de órgãos (Organ transplant)” e “Impacto (Impact)”. Resultados: Foram encontrados 24 artigos. Diante da emergência da situação provocada pela síndrome respiratória aguda causada pela Covid-19, houve ocupação de unidades de terapia intensiva (UTI), gerando indisponibilidade de leitos para pacientes transplantados. O número de transplantes sofreu decréscimo diante dos impactos da pandemia de Covid-19. Conclusões: A pandemia de Covid-19 impactou os receptores de órgãos na diminuição de transplantes e doação de órgãos, repercutindo nos aspectos emocionais e psicológicos dos pacientes e de suas famílias, bem como dos profissionais de saúde, cujo desafio é garantir a continuidade dos procedimentos. Nota-se a importância da promoção de políticas públicas que favoreçam a melhor organização e disponibilidade de leitos para a realização de transplantes

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Referências

Danziger-Isakov L, Blumberg EA, Manuel O, Sester M. Impact of COVID-19 in solid organ transplant recipients. Am J Transplant. 2021 Mar;21(3):925-37. Available from: https://doi.org/10.1111/ajt.16449.

Aubert O. et al. COVID-19 pandemic and worldwide organ transplantation: a population-based study. The Lancet. Public health, [S.l.], 2021; 10(6):e709-e719. Available from: https://doi.org/10.1016/S2468-2667(21)00200-0.

Trubin PA, Azar MM, Malinis M. Diagnostic Testing of COVID-19 in Solid Organ Transplantation: Current Clinical Application and Future Strategies. Curr Transplant Rep. 2020;7(4):390-398. Available from: https://doi.org/10.1007/s40472-020-00307-w.

Miller J, Wey A, Valapour M, Hart A, Musgrove D, Hirose R, Ahn YS, Israni AK, Snyder JJ. Impact of COVID-19 pandemic on the size of US transplant waiting lists. Clin Transplant. 2022 May;36(5):e14596. Available from: https://doi.org/10.1111/ctr.14596. RBT, Registro Brasileiro de Transplantes, (2021). Disponível em: http:// www.rbt.org.br. Acesso em: 20 de maio de 2023.

Ribeiro Junior MAF, Costa CTK, Néder PR, Aveiro IA, Elias YGB, Augusto SS. Impact of COVID-19 on the number of transplants performed in Brazil during the pandemic. Current situation. Rev Col Bras Cir. 2021 Sep 24;48:e20213042. English, Portuguese. Available

from: https://doi.org/10.1590/0100-6991e-20213042.

RBT, Registro Brasileiro de Transplantes, (2020). Disponível em: http://www.rbt.org.br. Acesso em: 20 de maio de 2023.

Heldman MR, Kates OS. COVID-19 in Solid Organ Transplant Recipients: a Review of the Current Literature. Curr Treat Options Infect Dis. 2021;13(3):67-82. Available from: https://doi.org/10.1007/s40506-021-00249-6.

Cai Z, Cai X, Song Y, Wang D, Zhang Y, Ma S, Tang S, Bai H, Tan H, Li R, Yao L, Liu Z, Wang G, Wang Y. Psychological Distress and Its Association With Quality of Life in Organ Transplant Recipients During COVID-19 Pandemic. Front Psychiatry. 2021 Jun 24;12:690295. Available from: https://doi.org/10.3389/fpsyt.2021.690295.

Andrade LGM, Barbosa AMP, da Rocha NC, de Almeida Cardoso MM, de Almeida JTC, Machado-Rugolo J, Arantes LF, Pontes DFS, Ferreira GF. Impact of the COVID-19 Pandemic on Solid Organ Transplant and Rejection Episodes in Brazil’s Unified Healthcare System. J Clin Med. 2022 Nov 6;11(21):6581. Available from: https://doi.org/10.3390/jcm11216581.

Vries APJ, Alwayn IPJ, Hoek RAS, van den Berg AP, Ultee FCW, Vogelaar SM, Haase-Kromwijk BJJM, Heemskerk MBA, Hemke AC, Nijboer WN, Schaefer BS, Kuiper MA, de Jonge J, van der Kaaij NP, Reinders MEJ. Immediate impact of COVID-19 on transplant activity in the Netherlands. Transpl Immunol. 2020 Aug;61:101304. Available from: https://doi.org/ 10.1016/j.trim.2020.101304.

RBT, Registro Brasileiro de Transplantes, (2022). Disponível em: http://www.rbt.org.br. Acesso em: 20 de maio de 2023.

Bennett D, De Vita E, Ventura V, Bernazzali S, Fossi A, Paladini P, Luzzi L, Maccherini M, Valente S, Bargagli E, Frediani B, Sestini P. Impact of SARS-CoV-2 outbreak on heart and lung transplant: A patient-perspective survey. Transpl Infect Dis. 2021 Feb;23(1):e13428. Available from: https://doi.org/10.1111/tid.13428.

Forner-Puntonet M, Castell-Panisello E, Quintero J, Ariceta G, Gran F, Iglesias-Serrano I, Gisbert-Gustemps L, Daigre C, Ibañez-Jimenez P, Delgado M, Español-Martín G, Parramon G, Pont T, Ramos-Quiroga JA. Impact of COVID-19 on Families of Pediatric Solid Organ Transplant Recipients. J Pediatr Psychol. 2021 Aug 19;46(8):927-938. Available from: https://doi.org/10.1093/jpepsy/jsab058.

Kute VB, Tullius SG, Rane H, Chauhan S, Mishra V, Meshram HS. Global Impact of the COVID-19 Pandemic on Solid Organ Transplant. Transplant Proc. 2022 Jul-Aug;54(6):1412-1416. Available from: https://doi.org/10.1016/j.transproceed.2022.02.009.

Feldman AG, Danziger-Isakov LA. The impact of COVID-19 on the pediatric solid organ transplant population. Semin Pediatr Surg. 2022 Jun;31(3):151178. Available from: https://doi.org/10.1016/j.sempedsurg.2022.151178.

Zhang M, Wang G, Li J, Hopp WJ, Lee DD. Pausing transplants in the face of a global pandemic: Patient survival implications. Prod Oper Manag. 2022 Mar 7:10.1111/poms.13697. Available from: https://doi.org/10.1111/poms.13697.

Shafiekhani M, Shahabinezhad F, Tavakoli Z, Tarakmeh T, Haem E, Sari N, Nasirabadi S, Dehghani M. Quality of life associated with immunosuppressant treatment adherence in liver transplant recipients: A cross-sectional study. Front Pharmacol. 2023 Feb 24;14:1051350. Available f rom: https://doi.org/10.3389/fphar.2023.1051350.

GODT – Global Observatory on Donation and Transplantation. Global report on organ donation and transplantation 2020. Coordinación editorial: Río Jarama, 2020. Disponível em: https://www.transplant-observatory.org/2020-internationctivities-report-%e2%80%8e/

Balsara KR, Rahaman Z, Sandhaus E, Hoffman J, Zalawadiya S, McMaster W, Lindenfeld J, Wigger M, Absi T, Brinkley DM, Menachem J, Punnoose L, Sacks S, Schlendorf K, Shah AS. Prioritizing heart transplantation during the COVID-19 pandemic. J Card Surg. 2021 Sep;36(9):3217-21. Available from: https://doi.org/10.1111/jocs.15731.

Pecly IMD, Azevedo RB, Muxfeldt ES, Botelho BG, Albuquerque GG, Diniz PHP, et al. COVID-19 and chronic kidney disease: a comprehensive review. Braz J Nephrol [Internet]. 2021Jul;43(3):383-99. Available from: https://doi.org/10.1590/2175-8239-JBN-2020-0203.

Gatti M, Rinaldi M, Bussini L, Bonazzetti C, Pascale R, Pasquini Z, et al. Clinical outcome in solid organ transplant recipients affected by COVID-19 compared to general population: a systematic review and meta-analysis. Clin Microbiol Infect. 2022 Aug;28(8):1057-65. Available from: https://doi.org/10.1016/j.cmi.2022.02.039.

Kute V, Meshram HS, Fleetwood VA, Chauhan S, Lentine KL. Solid Organ Transplantation in SARS-CoV-2 Recovered Transplant Candidates: a Comprehensive Review of Recent Literature. Curr Transplant Rep. 2022;9(2):95-107. Available from: https://doi.org/10.1007/s40472-022-00362-5.

Passoni R, Gadonski B, Carvalho ARDS, Freitas TVS, Peres LAB. The impact of COVID-19 on kidney transplant activities in Brazil: a descriptive study. Sao Paulo Med J. 2023 Jan-Feb;141(1):60-6. Available from: https://doi.org/10.1590/1516-3180.2021.0956.R1.29042022.

Domínguez-Gil B, Fernández-Ruiz M, Hernández D, Crespo M, Colmenero J, Coll E, Rubio JJ. Organ Donation and Transplantation During the COVID-19 Pandemic: A Summary of the Spanish Experience. Transplantation. 2021 Jan 1;105(1):29-36. Available from: https://doi.org/10.1097/TP.0000000000003528.

Peters TG, Bragg-Gresham JL, Klopstock AC, Roberts JP, Chertow G, McCormick F, Held PJ. Estimated impact of novel coronavirus-19 and transplant center inactivity on end-stage renal disease-related patient mortality in the United States. Clin Transplant. 2021 Aug;35(8):e14292. Available from: https://doi.org/10.1111/ctr.14292.

ABTO – Associação Brasileira de Transplante de órgãos. ABTO recomenda manter os transplantes ativos o quanto for possível. [internet] Brasil, 2020. Disponível em: https://site.abto.org.br/blog/informacoes/abto-recomenda-manter-os-transplantes-ativos-o-quanto-for-possivel/

Hudgins JJ, Boyer AJ, Orr KD, Hostetler CA, Orlowski JP, Squires RA. The Impact and Implications of The COVID-19 Pandemic on Organ Procurement Outside of an Epicenter. Prog Transplant. 2021 Jun;31(2):171-3. Available from: https://doi.org/10.1177/15269248211002808.

Linares L, Cofan F, Diekmann F, Herrera S, Marcos MA, Castel MA, Farrero M, Colmenero J, Ruiz P, Crespo G, Llopis J, Garcia-Vidal C, Soriano À, Moreno A, Bodro M; Hospital Clínic COVID-19 research group. A propensity score-matched analysis of mortality in solid organ transplant patients with COVID-19 compared to non-solid organ transplant patients. PLoS One. 2021 Mar 3;16(3):e0247251. Available from: https://doi.org/10.1371/journal.pone.0247251.

Desmazes-Dufeu N, Coltey B, Amari L, Gouitaa M, Touzery C, Reynaud-Gaubert M, Chanez P, Cassir N. Discordant courses of COVID-19 in a cohabiting couple of lung transplant recipients. Transpl Infect Dis. 2021 Feb;23(1):e13410. Available from: https://doi.org/10.1111/tid.13410.

Smith AC, Thomas E, Snoswell CL, Haydon H, Mehrotra A, Clemensen J, Caffery LJ. Telehealth for global emergencies: Implications for coronavirus disease 2019 (COVID-19). J Telemed Telecare. 2020 Jun;26(5):309-13. Available from: https://doi.org/10.1177/1357633X20916567.

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2023-12-29

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Fonseca CBA, Paes KS, Cardoso RAB, Gonçalves MV, Candido MH, Neves SBDA, Destefano G, Villela EFM, Zanuzzi TRL, Oliveira FM. Múltiplos efeitos da pandemia de Covid-19 no contexto do transplante de órgãos no Brasil e no mundo. Bepa [Internet]. 29º de dezembro de 2023 [citado 28º de abril de 2024];20:e39591. Disponível em: https://periodicos.saude.sp.gov.br/BEPA182/article/view/39591

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