Palavras-chave
Infecção Hospitalar
Políticas Públicas
Coinfecção
Resistência Bacteriana a antibióticos
Como Citar
Resumo
Introdução: Resistência bacteriana é uma ameaça global associada a surtos hospitalares. Objetivo: Rapidez diagnóstica e comparação metodológica na detecção de carbapenemases. Métodos: A detecção de carbapenemases foi realizada pelo teste GeneXpert Carba-R e cultura bacteriana seguido de PCR multiplex com identificação de complexos clonais. Resultados: Foram incluídos 155 pacientes, 73 mulheres e 82 homens entre 21 e 86 anos, sendo a maioria internados na unidade de terapia intensiva (98). Foram realizados 163 testes: swabs retais (93), urinas (36), swabs retais (8) e urinas (8) e secreções pulmonares (18). A cultura detectou bactérias resistentes (51): Klebsiella pneumoniae (24), A. baumannii (19), Pseudomonas aeruginosa (7) e Providencia rettgeri. De acordo com o Xpert Carba-R, a maioria dos pacientes apresentou blaKPC (26) e 123 pacientes foram relatados como não detectados (ND). Dos 18 resultados Xpert ND, mas com crescimento de A. baumannii na cultura, foi observada a prevalência de blaOXA-23 e blaOXA-51/CC-02. Conclusão: A detecção precoce de isolados produtores de carbapenemases, por meio do teste Xpert Carba-R em 48 minutos, serve como guia para planejamento de políticas públicas. Contudo, como o teste está limitado à detecção de cinco genes, devemos manter os métodos fenotípicos “padrão ouro”, cultura e antibiograma, para evitarmos falsos-negativos.
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Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 2025 Ana Beatriz Nascimento Costa, Ana Carolina Cavalcante Tiburcio, Akemi Oshiro Guirelli, Andréia Moreira dos Santos Carmo, Vilma dos Santos Menezes Gaiotto Daros, Ivana Barros de Campos, Jaqueline Maria Gerbase, Maria Edvania Ferreira Teodoro, Murilo Carlos Britto, Murillo Magalhães Rocha, Carlos Henrique Camargo, Amanda Yaeko Yamada, Daniel de Sena Miranda, Alice Siniauskas, Bárbara Albares, Christiane Priscile Salvador, Maria Solange Duarte Soares, Maria Cecilia Cergole-Novella