Resumo
Foi feito um apanhado da literatura científica, no que concerne à toxicidade dos ácidos cítrico, tartárico, málico, lático, fumárico, glicônico, glicólico e fosfórico. A toxicidade crônica desses ácidos cresce na seguinte ordem: cítrico, málico, lático, tartárico, fumárico, glicônico, glicólico e fosfórico. Todos os ácidos mencionados se mostram adequados para serem usados em alimentos e bebidas.
Referências
1. BARNEs, R. H. e A. LERNER - 1943 - Metabolism of glycolic and glyxylic acids. Proc. Soc. Exp. Biol. Med. 52: 216-219.
2. BODANSKY,O., H. GOLDe W. ZAHM- 1942 - The toxicity and laxative action of sodium fumarate. J. Am. Pharm. Assoe. 31: 1-8.
3. BORDAs, F. - 1927 - L'acide lactique dans l'alimentation. Ann. Fals. Fraudes 20 : 472-477. Resumo em Chem. Abstraets 1928, 22: 643.
4. CAMBOSU,G. - 1940 - Studio sulla depurazione biológica delle acque mediante l'impiego dell'acido tartarico. Igiene Moderna 33: 74-80.
5. CAUTRU, F. - 1904 - L'acide phosphorique. Son innocuité. Ses principales indications en thérapeutique. Presse M édicale 74: 488-589.
6. COLLAZO,J. A., J. PUYAL e L TORRES - 1932 - EI ácido d. 1. láctico considerado como alimento. L Su asimilación y toxicidad en el conejo. An. Casa Salud Valeilla 3: 253-265 e An. Soe. Espan. Fie. Quím. 1933, 31: 672-684. Resumo em Chem. Abstraets 1934, 28: 531.
7. CORBIAU, L. - 1936 - Modifications de Ia phosphatémie provoquées par l'ingestion journaliere de phosphate bisodique, C. R. Soe. Biol. 122: 474-475.
8. DAKIN, H. D. - Oxidations and reductions in the animal body. 2. ed., Londres, Longmans, Grenn & Co., 1922. p. 176.
9. DEFREN, G. A. - 1920 - Use of refined lactic acid in food products. Chem: Age (N. Y.) 2: 478-479.
10. FINKLE, P. - 1933~ The fate of tartaric acid in the human body. J. Biol. Chem. 100 : 349-355.
11. FITZHUGH, O. G. e A. A. NELSON- 1947 - The comparative chronic toxicities of fumario, tartaric, oxalic, and maleic acids. J. Am. Pharm. Assoe. 36: 217-219.
12. FROSINI, R. - 1940 - On the use of organic acids for the disinfection of water supplies. Içiene Moderna 33: 193. Resumo em Chem. Abstracts 1944, 38: 5342.
13. FÜRTH, O. e P. ENGEL - 1930 - Über die Assimilierbarkeit und Toxizitãt razemischer Milchsâure. Bioehem. Ztsehr. 229: 381-396. Resumo em Chem. Abstracts 1931, 25: 1588.
14. GAJATTO, S. - 1939 - Ricerche íarmacologiche sul fosfato monosodico. Areh. Farmaeol. Sper. 68: 87-98.
15. GOLD, H. e H. CIVIN - 1939 - Gluconic acid as a urinary acidiíying agent in mano J. Lab. Clin. Med. 24: 1139-1146.
16. GoLD, H. e W. ZAHM- 1943 - A method for the evaluation of laxative agents in constipated human subjects, with a study of the comparative laxative potency of fumarates, sodium tartrate and magnesium acid citrate. J. Am. Pharm. Assoc. 32: 173-178.
17. GOODMAN,L. e A. GILMAN- The pharmacological basis of therapeutics. New York, Macmillan, 1941; p. 615, 721 e 730.
18. GREENFIELD, 1.- 1941 - The effect of the intravenous administion in normalrabbits. J. Lab. Clin. Med. 27: 68-70. .
19. GRIESBACH,H. - 1928 - Nochmals Recresal und Leistunsfahigkeit. Med. Welt. 2: 1818.:
20. GRIFFITH, W. H. - 1930 - Eífect of glucosamine and of glycolic acid on detoxication of sodium banzoate in rats. Proe. Soe. Exp. Biol. Med. 28: 216-217.
21. GRUBERJR., C. M. e W. A. HALBEISEN,-- 1948 - Study on comparative toxic effects of citric acid and its sodium salts. J. Pharmaeol. Exp. Therap. 94: 65-67.
22. GUEYLARD,F. e M. DUVAL- 1922 - Toxicité comparée de divers acides pour les possons (Epinoches). C. R. Acad. Sei. 175: 1243-1245.
23. HAGER, H. - Tratado de Farmacia Prática. Trad. 3. ed. alemã, Barcelona, Labor S.A., 1942; I: 261 e 263.
24. HERMANN, S. - 1930 - Zur Pharmakologie der Glukonsãure ; ein Beitrag zum Problem der Wirkung freier Sãuren im Organismus. Arch. Exp. Path. Pharmakol. 154: 143-160. Resumo em Chem. Abstracis 1931, 25: 3068.
25. HERMANN, S. - 1947 - Some paradoxical effects in experimental pharmacology. Exp. Med. Surg. 5: 160-162.
26. HERMANN, S. e M. ZENTNER- 1938 - Ausscheidung peroral verabreichter Sãuren und ihrer Salze im Kaninchenharn. Arch, Exp. Path. Pharmarkol. 188: 518-520. Resumo em Chem. Abstraets 1939, 33: 5499.
27. KRANTZ Jr., J. C., A. A. SILVERe B. J. HOFF~!AN- 1931 - The effect of sodium malate combinations upon gastric aeidity. Ann. Int. Med. 4: 1441-1446. Resumo em Chem. Abstracts 1931, 25: 5210.
28. KROP, S. e H. H. GOLD- 1945 - On the toxicity of hydroxyacetic acid after prolonged administration: comparison with its sodium salt and citric and tartaric aeids. J. Am. Pharm. Assoc. 34: 86-89.
29. KUIPER, A. C. e H. A. MATTILL- 1933 - Some aspects of citric acid metabolismo J. Biol. Chem. 103: 51-60.
30. LEBEAU, P. e G. COURTOIS- Traité de Pharmacie Chimique. 3. ed., Paris, Masson et Cie., 1946; I: 246-247.
31. LECOQ, M. R. - 1936 - Production de polynévrite aviaire au moyen de régimes riches en glucides, en protides ou en lipides, comportant de fortes doses de vitamines B, par simple addition d'acide lactique. C. R. Acad. Sei. 202: 1304-1307.
32. LECOQ (Lecocq!), R. e F. VILLUIS - 1932 - Action de quelques dérivés calciques SUl' l'évolution du rachitisme expérimental du rato C. R. Soe. Biol. 109: 539-541.
33. LECOQ, R. e F. VILLUIS- 1932a - Action de quelques composés inorganiques du phosphore sur l'évolution du rachitisme expérimental du rato C. R. Soe. Biol. 109: 630-631.
34. LECOQ, R. e F. VILLUIS- 1932b - Action de quelques glycérophosphates sur l'évolution du rachitisme expérimental du rato C. R. Soe. Biol. llO: 687-689.
35. LECOQ, R. e VILLETTE - 1933 - Influence du métal sur l'activité antirachitique des orthophosphates. C. R. Soe. Biol. ll4: 1096-1098.
36. LECOQ, e H. VILLETTE (Vilete!) - 1933a - Phosphorous and rickets. lI. The role of phosphate ion in antirachitic activity of inorganic compounds of phosphorus. J. Pharm. Chim. 18: 192-197. Resumo em Chem. Abstraets 1934, 28: 510.
37. LESCHKE, VON EruCH - 1932 - Fortschritte in der Erkennung und Behandlung der wichtigsten Vergiftungen. XI. Vergiftungen mit Oxalsãure, Zitronen-, Milch-sund Pikrinsâurs. Müneh. Med. Woehseh. 79: l481-1482.
38. LEVEIY, S., A. G. LASICHAK,R. BRn~I, J. M. ORTEN, C. J. SMYTH, e A. H. SlVUTH1946 - A study to determine the toxicity of fumaric acid. J. Am. Pharm. Assoc. 35: 298-304.
39. LOCKE, A., R. B. LOCKE, H. SCHLESINGERe H. CARR- 1942 - The comparative toxicity and cathartic efficiency of disodium tartrate and fumarate, and magnesium fumarate, for the mouse and rabbit. J. Am. Pharm. Assoe. 31: 12-14.
40. MCGLURE, F. J. e -J. RUZICKA- 1946 - The destructive effect of citrate vs. Iactate ions on rats'molar tooth surfaces, in vivo. J. Deni, Researeh 25: 1-12.
41. NEGRO, G. e G. BERTASSO- 1940 - Epurazione biologica individuale di acqua da bere mediante trattamento con acido tartarico. Giorn. Batt. Immun. 25: 687-698.
42. NEUWIRTH, I. e J. A. KLOSTERMAN- 1940 - Demonstration of rapid production of lactic acid in oral cavity. Proc, Soe. Exp. Biol. Med. 45: 464-467.
43. NEWMAN, WM. A. - 1948 - Dental observations of native Puerto Ricans with special reference to their habits of citrus fruit consumption. U. S. Naval Med. Bull, 48 : 698-699. Resumo em Chem. Abstraets 1948, 42: 8909.
44. NOORDEN, C. von - 1921 - Uber Phosphorsãure in der Kost und als Medikament. Therap. Halbmonatshejte 35: 79-82.
45. NORPOTH, L. e E. KADEN - 1933 - Untersuchungen über die Milchsãure des Magensaftes. Arch. Exp. Path. Pharmalcol, 169: 414-428.
46. PICKENS,L. M. e R.. A. HETLER-1930 - The effect of grape juice on nitrogcn. retention and urinary acidity. J. Home Econ: 22: 44-48.
47. POPPELREUTER, W. - 1930 - Zur Frage der Steigerrung der industriellen ArbeitsIãhigkeit durch Recresalzufuhr. Arbeitsphysiologie 2: 507-518. -
48. POPPELREUTER, W. - 1930a - Selbstbeobachtungen über die Wirkung jahrelanger Phosphatzufuhr. Arbeitsphysiologie 3: 605-611.
49. REUTTER, L. - Traité de Chimie Pharmaceutique. Paris, J. B. Bailliere et Fils, 1939 ; p. 18.
50. RHAN(,K. - 1932 - Über die Wirkung des Recresals auf die kõrperliche und geistige Leistungsfãhigkeit. Arch. Ges. Psykol. 86: 459-522.
51. ROLIM,R. - 1942 - A acidificação do vitreo no tratamento do glaucoma. Brasil-M edico 56: 332-333.
52. SCHMITZ,E. - 1943 - Behavior of carbohydrates in the mouth. Ernõhrunq 8: 196-202. Resumo em Chem. Abstracts 1945, 39: 346.
53. SEELING, M. G., D. J. VERDAe F. H. KIDD - 1943 - The talcum powder problem in surgery and its solution. J. A. M. A. 123: 950:954.
54. SHEAR, M. J., B. KRAMER e L. RESNIKOFF - 1929 - Composition of bone. VIII. Conductivity titrations of calcium ions with chloride, acetate, lactate, and citrate ions at 38.0 J. Biol. Chem, 83: 721-735.
55. SHERMANN,C. C., L. B. MENDEL e A. H. SN(ITH- 1936 - The metabolism of orally administered citric acid. J. Biol. Chem. 113: 265-271.
56. SISK, L R. e O. TOENHART- 1938 - Gluconic acid as urinary acidifying agent. J. Urology 39: 699-709.
57. SMYTH,C. J., R. BRUNDAGE,J. M. ORTEN e A. H. SMITH- 1945 - Fumaric acid salts as hydrogogue cathartics. Proe. Soe. Exp. Biol. Med. 60: 301-303.
58. SOLLMANN,T. - A Manual of Pharmacology. 6. ed., Philadelphia, W. B. Saunders, 1944; p. 883.
59. STAFNE, E. C. e S. A. LOVESTEDT- 1947 - Dissolution of tooth substance by lemon juice, acid beverages and acids from some other sources. J. Am. Dent. Assoc. 34: 586-592.
60. UNDERHILL, F. P. e G. T. PACK - 1925 - Pharmacological behavior of malic acid and its salts. J. Pharmaeol. Exp. Therap. 25: 467-485. Resumo em Chem. Abstraets 1925, 19: 3122.
61. UNDERHILL,F. P., C. S. LEONARD,E. G. GROSSe T. C.JALESKI - 1931 - Studies on metabolism of tartrates; behavior of tartrate in organism of rabbit, dog, rat and guinea pig. J. Pharmacol. Exp. Therap. 43: 359-380.
62. UNDERHILL,F. P., F. I. PETERMAN,T. C. JALESKI e C. S. LEONARD- 1931-Studies on metabolism of tartrates; behavior of tartrates in human body, J. Pharmacolo Exp. Therap. 43: 381-398.
63. VIOLLE, H. - 1937 - Contribution à l'átude de Ia destruction des germes pathogenes dans l'eau de boisson par l'acide tartrique suivi ou non de sa neutralisation. Presse Médieale 45: 1355-1356.
64. VLADESCO,RADU - 1936 - Sur Ia présence de l'acide lactique dans Ia salive. C. R. Soc. Biol. 121: 275-276.
65. WEISS, J. M., C. R. DOWNS e H. P. CORSON - 1923 - Inactive malic acid as a food aeidulent. Indust. Engin. Chem. 15: 628-630.
66. WISE, L. E. - 1916 - Elimination of malates after subcutar eoi.s injection of sodium malate. J. Biol. Chem. 28: 185-196.
67. ZIPKIN, r. - 1947 - Citric acid in saliva. Science 106: 343.
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Copyright (c) 1951 Germínio Nazário