Citologia de base líqüida associada à captura de híbridos para DNAHPV pode otimizar a qualidade diagnóstica do método de Papanicolaou?

Autores

  • Maria Lúcia Utagawa Instituto Adolfo Lutz
  • Sônia Maria Miranda Pereira Instituto Adolfo Lutz
  • Adhemar Longatto Filho Instituto Adolfo Lutz
  • Cecília Roteli- Martins Hospital Leonor Mendes de Barros
  • Luciana Silva Aguiar Instituto Adolfo Lutz
  • Janaína Érika Pittoli Instituto Adolfo Lutz
  • Celso Di Loreto Instituto Adolfo Lutz
  • Marina Yoshiê Sakamoto Maeda Instituto Adolfo Lutz
  • Laura Martins Hospital Leonor Mendes de Barros
  • Janice O. Galvane Hospital Leonor Mendes de Barros
  • Kari Syrjänen Instituto Superiore di Sanità, Roma Italia

Palavras-chave:

método de Papanicolaou, ASCUS, captura de híbridos, citologia de base líquida, reflex testing

Resumo

A associação da citologia de base liquida (BL) e o teste de Captura de Híbridos II (HC2) para DNA HPV poderão otimizar o diagnóstico citológico, sobretudo os de origem indeterminada (ASCUS/AGUS). Avaliamos as amostras colhidas com o sistema DNA-CITOLIQ® (DIGENE-Brasil) para citologia de BL e HC2, de pacientes atendidas no Hospital Leonor Mendes de Barros. Foram realizados 842 exames de citologia de BL e HC2, onde 64 (7,6%) amostras apresentaram atipias de significado indeterminado (ASCUS/AGUS) de citologia na BL. O HC2 para DNA HPV de alto risco foi positiva em 16 (25%) amostras de ASCUS e quatro (6,2%) de atipia glandular (AGUS). De 748 amostras, 88,8% foram citologicamente negativas e destas 97 (11,5%) foram positivas para HPV de alto risco. Essas alterações estão associadas à infecção pelo HPV e , portanto, colocam a paciente em um grupo com conduta diferenciada da população normal. Adicionalmente, os casos com resultados negativos no exame citológico, que nos testes de DNA HPV foram positivos, demonstraram a elevada sensibilidade das técnicas biomoleculares em relação à morfologia. Concluímos que a citologia de BL associada ao HC2, pode melhorar a sensibilidade do método de Papanicolaou.

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Referências

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Publicado

2004-12-30

Como Citar

Utagawa, M. L. ., Pereira, S. M. M. ., Longatto Filho, A. ., Martins, C. R.-., Aguiar, L. S. ., Pittoli, J. Érika ., Di Loreto, C. ., Maeda, M. Y. S. ., Martins, L. ., Galvane, J. O. ., & Syrjänen, K. . (2004). Citologia de base líqüida associada à captura de híbridos para DNAHPV pode otimizar a qualidade diagnóstica do método de Papanicolaou?. Revista Do Instituto Adolfo Lutz, 63(1), 100–103. Recuperado de https://periodicos.saude.sp.gov.br/RIAL/article/view/34801

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