Keywords
meningitis, bacterial, laboratorial diagnosis
meningitis, bacterial, anti- microbial drugs interference in etiological elucidation
meningitis, bacterial, anti- microbial drugs interference in etiological elucidation
How to Cite
1.
Melles CEA. Bacterial meningitis. I. Interference of antimicrobial drugs in cerebrospinal fluid for etiological diagnosis. Rev Inst Adolfo Lutz [Internet]. 1988 Dec. 30 [cited 2024 May 18];48(1-2):43-7. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/36905
Abstract
Cerebrospinal tluid (CSF) samples from 641 patients who were cJinically suspected that were suffering from bacterial meningitis were analyzed. The presence of antimicrobial drugs was detected in 247 (38.50%)samples. The etiological agent was identified in 388 (60.53%) samples by means of bacteriological procedures and counter-immunoelectrophoresis (ClE) assay for antigen detection. lt was observed that the occurrence of antimicrobial drugs in
CSF significantly decreases the finding of etiological agent (p<0,05), and the chemoterapeutic agent's concentrations, measured by the size of inibition zone, were significantly smaller in those samples where the etiological agent was identified (p<O,05). According to lhese data, the presence of antimicrobial drugs in CSF may interfere with the laboratorial diagnosis for identification of bacterial meningitis' etiological agent.
References
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13. HARTER, D.H. - Preliminary antibiotic therapy in bacterial meningitis. Arch. Neurol. 9:343-347, 1963.
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15. HYLAND, H.H. - Modern experience in bacterial meningitis. Canomedo Assoc. J. 81(11):883-335, 1959.
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18. LIMA, J.P.C. - Meningites bacterianas em São Paulo. An. paul. Med. Cirurg. 24(3):145-149, 1932.
19. MELLES, C.E.A.; RAMIRES, M.R.N.; DINIZ, J.M.P.; ADELINO, .G.F.; TAUNAY, A.E. & ROSSI, C.V. - Estudo comparativo de métodos diagnósticos das meningites purulentas. Rev. Inst. Med. trop. S. Paulo, 20(4):202-207, 1978.
20. MELLES, C.E.A.; LEE, I.M.L. & TAUNAY, A.E. - Pesquisa de antibacterianos no líquido cefalorraquidiano. Rev. Inst. Adolfo Lutz, 44(2):155-159, 1984.
21. Ministério da Saúde-Secretaria Nacional de Ações Básicas de Saúde. Divisão Nacional de Laboratórios de Saúde Pública. - Normas Técnicas para o diagnóstico das meningites bacterianas. Brasilia, Centro de Documentação do Ministério da Saúde, 1986.
22. NEAL, l.B. - Influenzal meningitis. Arch, Pediat. 38:1-10, 1921.
23. NEAL, l.B. - Meningococic meningitis in children. JAMA 105(8):568-571, 1935.
24. QUAADE, F. & KRISTENSEN, K.P. - Purulent meningitis. A review of 658 cases. Acta. medo scand. 171(5):543-550, 1962.
25. ROMER, F.K. -- Bacterial meningitis: a 15 years review of bacterial meningitis from deparrments of internal medicine. Dan. medo Buli. 24(1):35-40, 1977.
26. SCHMID, A.E. & GALVÃO, P.A.L.A. -- Alguns aspectos epidemiológicos da meningite meningocócica no município de São Paulo. Arq. Hig. Saúde publ. 26(87):15-39, 1961.
27. WILSON, F.M. & LERNER, A.M. - Etiology and mortality of purulent rneningitis at the Detroit receiving hospital. New Engl. J. Med. 271(24):1235-1238, 1964.
2. CARVALHO, E.S.; NISKIER, H.; PESSOA, M.C.; CARVALHO, L.H.F.R. &FARHAT, K.C. - Incidência das meningites bacterianas. Clin. geral 12(4):23-25, 1978.
3. COLONNELO, F. - Les meningites suppurées traitées. G. Mal. infect. 18(11):724-739, 1966.
4. DE MATTIA, R. & DI NOLA, F. - Aspetti epidemiologici e clinici delle meningiti purulente. G. Mal. Infeet. 20(5):406-411,448,1968.
5. DUPOUY, D.; MESMIN, F.; PENNAFORTE, F.; PUIG, M.T. & COUCHOT, J. - Les méningites purulentes du nourrisson et de l'enfant: a propos de 144 observations. Ann. Pédiat. 18(8/9):507-516, 1971.
6. ESRACHOWITZ, S.R. - Pyogenic meningitis. - A study of 303 cases. S. Afr. med. J. 35(3):101-104, 1961.
7. FINLAND, W.E.; JONES, Jr., W.F. & BARNES, M.W. - Occurrence of serious bacterial infections since introduction of antibacterial agents. JAMA 170(18):2188-2197, 1959.
8. FRASER, D.W.; MITCHELL, J.E.; SILVERMAN, L.P. & FELDMAN, R.A. - Undiagnosed bacterial meningitis in Vermont children. Amer. J. Epidemiol. 102(5):394-399, 1975.
9. GONZALES, A.F. - Bacteriologia de las meningites purulentas através de cinco campañas de epidemia (1970-71, 1971-72, 1972-73, 1973-74, Y 1974-75). Rev. Sanid. Hig. publ. 51(3/4):325-339, 1977.
10. GOMES, L.S.S.; BRITO E SILVA, N.; RIBAS, J.C.; RUGAY, E.; AMOROSINO, A. & DELLE CAVE, J.J. - Meningite cerebro-espinhal e sulfamidação maciça preventiva. Rev. Inst. Adolfo Lutz, 10:77-87, 1950.
11. GROOVER, R.V.; SUTHERLAND, J.M. & LANDING, B.H. - Purulent meningitis of newborn infants. New Engl. J. Med. 264(22):
1115-1121,1961.
12. HAGGERTY, a.r. & ZIAI, M. - Acute bacterial meningitis. Adv. Pediat. 13:129-181, 1964.
13. HARTER, D.H. - Preliminary antibiotic therapy in bacterial meningitis. Arch. Neurol. 9:343-347, 1963.
14. HEYCOCK, M.C. - Partilly treated meningitis in infants. Brit. medo J. 1(5122):629-630, 1959.
15. HYLAND, H.H. - Modern experience in bacterial meningitis. Canomedo Assoc. J. 81(11):883-335, 1959.
16. JONES, R.G. - Bacterial meningitis. Part I. Incidence and diagnosis. S. Afr. medo J. 41:75-79, 1967.
17. JONSSON, M. & ALVIN, A. - A 12-year review of acute bacterial meningitis in Stockholm. Seand. J. infect. Dis. 3(2):141-150, 1971.
18. LIMA, J.P.C. - Meningites bacterianas em São Paulo. An. paul. Med. Cirurg. 24(3):145-149, 1932.
19. MELLES, C.E.A.; RAMIRES, M.R.N.; DINIZ, J.M.P.; ADELINO, .G.F.; TAUNAY, A.E. & ROSSI, C.V. - Estudo comparativo de métodos diagnósticos das meningites purulentas. Rev. Inst. Med. trop. S. Paulo, 20(4):202-207, 1978.
20. MELLES, C.E.A.; LEE, I.M.L. & TAUNAY, A.E. - Pesquisa de antibacterianos no líquido cefalorraquidiano. Rev. Inst. Adolfo Lutz, 44(2):155-159, 1984.
21. Ministério da Saúde-Secretaria Nacional de Ações Básicas de Saúde. Divisão Nacional de Laboratórios de Saúde Pública. - Normas Técnicas para o diagnóstico das meningites bacterianas. Brasilia, Centro de Documentação do Ministério da Saúde, 1986.
22. NEAL, l.B. - Influenzal meningitis. Arch, Pediat. 38:1-10, 1921.
23. NEAL, l.B. - Meningococic meningitis in children. JAMA 105(8):568-571, 1935.
24. QUAADE, F. & KRISTENSEN, K.P. - Purulent meningitis. A review of 658 cases. Acta. medo scand. 171(5):543-550, 1962.
25. ROMER, F.K. -- Bacterial meningitis: a 15 years review of bacterial meningitis from deparrments of internal medicine. Dan. medo Buli. 24(1):35-40, 1977.
26. SCHMID, A.E. & GALVÃO, P.A.L.A. -- Alguns aspectos epidemiológicos da meningite meningocócica no município de São Paulo. Arq. Hig. Saúde publ. 26(87):15-39, 1961.
27. WILSON, F.M. & LERNER, A.M. - Etiology and mortality of purulent rneningitis at the Detroit receiving hospital. New Engl. J. Med. 271(24):1235-1238, 1964.
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Copyright (c) 1988 Instituto Adolfo Lutz Journal
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