A relação entre polimorfismos de IL-4 e asma: uma revisão sistemática

Autores

  • Marcos Jessé Abrahão Silva Universidade da Amazônia, Ananindeua, Pará, Brazil
  • Ellerson Oliveira Loureiro Monteiro Universidade da Amazônia, Ananindeua, Pará, Brazil
  • Bianca Benicio e Silva Universidade da Amazônia, Ananindeua, Pará, Brazi
  • Debora Zoila da Conceição Martins Universidade da Amazônia, Ananindeua, Pará, Brazi
  • Andrei Santos Siqueira Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Tecnologia Biomolecular, Pará, Brazil
  • Bárbara Brasil Santana Universidade da Amazônia, Ananindeua, Pará, Brazil

DOI:

https://doi.org/10.53393/rial.2022.v81.37177

Palavras-chave:

Polimorfismos , Interleucina-4, Asma

Resumo

A asma é uma doença crônica e heterogênea das vias aéreas que tem início na infância e persiste em muitos casos até a vida adulta. A doença é resultado de interações ambientais, epigenéticas e genéticas. Este trabalho tem como objetivo revisar sobre os polimorfismos descritos na literatura no gene IL-4 associados à susceptibilidade ou proteção ao desenvolvimento da asma. Trata-se de uma revisão sistemática da literatura, feita nos bancos de dados PubMed, MEDLINE e Science Direct no corte temporal de 2000 a julho de 2021, ressaltando os seguintes pontos-chave: IL-4, Polimorfismos e Asma. A pesquisa resultou em 29 artigos, sendo em sua totalidade em língua inglesa. Apesar de alguns estudos divergentes, o SNP rs2243250, que foi o mais estudado em populações de diversos países, também foi o que mais encontrou correlações de susceptibilidade com a doença. Conclui-se que, apesar de haver dados controversos sobre os SNPs de IL-4 relacionados à doença, a associação dos estudos pangenômicos tem trazido uma lista de genes e variações deles associados com o risco de desenvolver a asma, como o SNP rs2243250 que foi bem relacionado em populações de vários países analisados.

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Arquivos adicionais

Publicado

2022-09-26

Como Citar

Silva, M. J. A., Monteiro, E. O. L., e Silva, B. B. ., Martins, D. Z. da C., Siqueira, A. S., & Santana, B. B. . (2022). A relação entre polimorfismos de IL-4 e asma: uma revisão sistemática. Revista Do Instituto Adolfo Lutz, 81, 1–22,e37177. https://doi.org/10.53393/rial.2022.v81.37177

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