Palavras-chave
Leishmania
Phlebotomíneo
Saliva
Como Citar
Resumo
A leishmaniose é uma enfermidade infecciosa causada por parasitos do gênero Leishmania que são transmitidos por insetos vetores. A infecção no hospedeiro vertebrado se estabelece no momento em que a fêmea do flebotomíneo infectada, ao realizar o repasto sanguíneo, regurgita na pele do mamífero as formas promastigotas metacíclicas do parasito juntamente com parte do conteúdo da glândula salivar do vetor. Tem sido descrito que componentes do conteúdo da saliva do vetor tem propriedades imunomodulatórias facilitando o estabelecimento da infecção no hospedeiro. Por outro lado, outros estudos mostram que a pré-sensibilização do hospedeiro vertebrado com saliva de flebotomíneo leva a proteção da infecção por Leishmania. Esta revisão teve como principal objetivo, revisar o papel da saliva na evolução da infecção por Leishmania, quer seja na exacerbação ou na proteção.
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Copyright (c) 2010 Márcia Dalastra Laurenti