Inhibitors of Tumor Necrosis Factor (Anti-Tnf) And Tuberculosis
Keywords:
Tumor Necrosis, Factor-alpha., Tuberculosis., Incidence., Autoimmune Diseases., Arthritis, Rheumatoid., Crohn Disease.Abstract
Introduction: The anti-TNF drugs (inhibitors of tumor necrosis factor), used to treat autoimmune diseases, increased the risk of reactivating latent infections, especially tuberculosis and other bacterial and fungal infections. Objective: to determine the tuberculosis incidence in patients taking Anti-TNF drugs, from 2006 to 2010. Methods: A retrospective, descriptive study was conducted. From a list of APACs (Authorization for High-Complexity Procedures)from patients using anti-TNF, provided by the State Secretariat of Health -SP,we searched TBweb database ( Reporting and Monitoring System of Tuberculosis Cases), to identify possible cases of tuberculosis. The RecLink III software, which implements the technique of probabilistic record linkage, was used. Results: Of the 10,631 anti-TNF users 57 tuberculosis cases were identified and reported to TBweb, whose database contained 76,079 records. Patients with tuberculosis after Anti- TNF use were 40, resulting in an incidence rate of 375.5 cases/100,000 patients taking the drug; 9.6 times higher than the general population, 39.2 cases/100,000 inhabitants. Conclusion: Despite the limitations of the study, arising from the fact of working with secondary data, there was an increase in the incidence of tuberculosis among patients undergoing treatment with Anti-TNF drugs, justifying the adoption of strategies for the prevention and monitoring of tuberculosis in patients treated with these drugs.
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Copyright (c) 2015 Vera Maria Neder Galesi, Edméa Costa Pereira, Regina Maura Cabral de Melo Abrahão, Péricles Alves Nogueira
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