Evolution of co-infection tuberculosis/HIV cases with positive culture after treatment outcome of tuberculosis
Keywords:
Tuberculosis, recurrence, HIV infectionAbstract
The objective of this paper was verifying the evolution of patients who obtained treatment discharge due to cure from Tuberculosis (TB), regarding the occurrence of recidivation, during the period comprised between 2002 and 2003. The method involved a transversal retrospective study, with the following inclusion criteria: TB cases with positive cultures, HIV positives, >18 years old, discharged from TB treatment and with outpatient clinic follow up, in a reference service for HIV/Aids attention in São Paulo (SP), Brazil. The following variables were evaluated: age, sex, clinical presentation, hospitalization, case type, TB treatment program and eventual changes in the program, hepatotoxicity, drug resistance, alcoholism, smoking, use of drugs, HAART, CD4, viral load, and immunodeficiency classification. In order to detect recurrence patients were subjected to 6,5 years follow up, after cure, by the information system TB-Web, from the Epidemiologic Surveillance Department of the Instituto de Infectologia Emilio Ribas. In order to evaluate statistic significance of the results, chi-square tests or Fischer´s exact test were both employed. A total of 39 patients were studied. There were 7 (17,9%) cases of recurrence. In the univariate analysis, not using the HAART [RR= 0,11 (IC95%:0,011-0,88); p = 0,05] proved to be associated to recurrence of tuberculosis. Results suggest that the use of HAART must be encouraged for patients registering coinfected with M. tuberculosis and HIV, in order to reduce TB recurrence.
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Copyright (c) 2010 Camila de Fátima Costa, Nilton José Fernandes Cavalcante
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