Câncer e modelos experimentais de tumores murinos
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Palavras-chave

câncer
imunologia
tumor experimental
modelos murinos
tumorigênese
células tumorais

Como Citar

1.
Pantaleão C, Luchs A. Câncer e modelos experimentais de tumores murinos. Rev Inst Adolfo Lutz [Internet]. 1º de abril de 2010 [citado 12º de outubro de 2024];69(4):439-45. Disponível em: https://periodicos.saude.sp.gov.br/RIAL/article/view/32599

Resumo

Nos últimos anos, a pesquisa do câncer proporcionou avanços importantes quanto à complexidade de desenvolvimento do tumor, em particular, sobre os mecanismos moleculares que são a base da transformação progressiva de células normais em derivados altamente malignos. A análise molecular do desenvolvimento tumoral em pacientes não é trivial, pois necessita da disponibilidade de biópsias em diversos estágios de transformação. Além disso, os estudos dos processos de metástase, de angiogênese e da resposta imune contra os tumores in vitro não mimetizam o que ocorre in vivo. Por esta razão, os modelos murinos experimentais de câncer têm desempenhado papel vital na compreensão da tumorigênese e suas relações com o ambiente in vivo, em que existe a dificuldade de avaliação de novos métodos diagnósticos e as ações terapêuticas de drogas contra tumores em pacientes. Nesta revisão, são discutidas as abordagens experimentais, técnicas e estratégias utilizadas no estudo de tumores em modelos murinos com ênfase na resposta imune contra o câncer e, ainda, as limitações conceituais e clínicas de cada sistema na sua aplicação no estudo do câncer em humanos.
https://doi.org/10.53393/rial.2010.v69.32599
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Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

Copyright (c) 2010 Claudia Pantaleão, Adriana Luchs

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