Intoxication by Colchicine in a compounded pharmaceutical formulation
Vol. 67 No. 3 (2008), CASE REPORT
Vol. 67 No. 3 (2008)

Intoxication by Colchicine in a compounded pharmaceutical formulation

CASE REPORT
https://doi.org/10.53393/rial.2008.67.32772
Published 2008-08-01
Helena Miyoco Yano
Instituto Adolfo Lutz, Divisão de Bromatologia e Química, Serviço de Medicamentos, São Paulo, SP
Adriana Bugno
Instituto Adolfo Lutz, Centro de Medicamentos, Cosméticos e Saneantes, Núcleo de Ensaios Biológicos e de Segurança, São Paulo, SP
Mariângela Tirico Auricchio
Instituto Adolfo Lutz, Divisão de Bromatologia e Química, Serviço de Medicamentos, São Paulo, SP
PDF (Português (Brasil))

Keywords

colchicine
compounded pharmaceutical formulation
overdose

How to Cite

1.
Yano HM, Bugno A, Auricchio MT. Intoxication by Colchicine in a compounded pharmaceutical formulation. Rev Inst Adolfo Lutz [Internet]. 2008 Aug. 1 [cited 2024 May 17];67(3):234-6. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/32772
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Abstract

The present work relate a case of overdose of colchicine in a capsules of compounded pharmaceutical formulation whose ingestion dose initiated a process of acute gastrointestinal haemorrhage leading the patient to death. Colchicine is a pharmacon of low therapeutical index drug, and the maximum recommended dose for gout treatment in adult is 2.5 mg at the first 24 hours. The remaining non- ingested capsules were analyzed by spectrophotometry, and colchicine amount was determined according to the Brazilian Pharmacopoeia, IV edition. The average dosage was of 47.36 mg, that is, about 20 times higher than the maximum recommended dose. The dosage mistake was evidenced in the medicament prescription, and also in consultation the professional responsible for prescribing the medicine on the part of operator who processed the colchicines formulation.
https://doi.org/10.53393/rial.2008.67.32772
PDF (Português (Brasil))

References

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Copyright (c) 2008 Instituto Adolfo Lutz Journal

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