Aspectos morfológicos e morfométricos do cérebro de ratos na intoxicação crônica pelo organofosforado metamidofós

Autores

  • Nilda M. Perez Instituto Emílio Ribas, Seção de Patologia, São Paulo, SP
  • Edenilson Eduardo Calore Instituto Emílio Ribas, Departamento de Patologia; Universidade de São Paulo, Faculdade de Medicina, São Paulo, SP
  • Liz Vilela-de-Almeida Instituto Emílio Ribas, Seção de Patologia, São Paulo, SP
  • Emerson S. Narciso Instituto Biológico de São Paulo, Departamento de Toxicologia, São Paulo, SP
  • Flávio R. Puga Instituto Biológico de São Paulo, Departamento de Toxicologia, São Paulo, SP

DOI:

https://doi.org/10.53393/rial.2006.65.32969

Palavras-chave:

cérebro, morfometria, organofosforado, inibidores de colinesterase, excitotoxicidade

Resumo

Foram descritos distúrbios neurológicos sutis após intoxicação por organofosforados. Estudos experimentais relataram necrose de neurônios, particularmente nos animais que apresentaram convulsões. O objetivo do presente trabalho foi investigar se ratos (que não tenham apresentado convulsões) expostos a um agente organofosforado, apresentaram alterações morfológicas em regiões específicas do cérebro. Os animais receberam 2.5 ou 5.0 mg/kg peso de metamidofos, uma vez por semana, por dois meses e foram decapitados dois meses e sete dias após a primeira administração da droga. Foi observada atrofia da camada molecular do córtex parietal sem perda neural em regiões específicas do cérebro. Isto pode ser devido a atrofia ou à perda de ramificações neurais mas sem perda de corpos neuronais.

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Publicado

2006-01-07

Como Citar

1.
Perez NM, Calore EE, Vilela-de-Almeida L, Narciso ES, Puga FR. Aspectos morfológicos e morfométricos do cérebro de ratos na intoxicação crônica pelo organofosforado metamidofós. Rev Inst Adolfo Lutz [Internet]. 7º de janeiro de 2006 [citado 1º de março de 2024];65(1):50-3. Disponível em: https://periodicos.saude.sp.gov.br/RIAL/article/view/32969

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