Palavras-chave
morfometria
organofosforado
inibidores de colinesterase
excitotoxicidade
Como Citar
Resumo
Foram descritos distúrbios neurológicos sutis após intoxicação por organofosforados. Estudos experimentais relataram necrose de neurônios, particularmente nos animais que apresentaram convulsões. O objetivo do presente trabalho foi investigar se ratos (que não tenham apresentado convulsões) expostos a um agente organofosforado, apresentaram alterações morfológicas em regiões específicas do cérebro. Os animais receberam 2.5 ou 5.0 mg/kg peso de metamidofos, uma vez por semana, por dois meses e foram decapitados dois meses e sete dias após a primeira administração da droga. Foi observada atrofia da camada molecular do córtex parietal sem perda neural em regiões específicas do cérebro. Isto pode ser devido a atrofia ou à perda de ramificações neurais mas sem perda de corpos neuronais.
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Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 2006 Nilda M. Perez, Edenilson Eduardo Calore, Liz Vilela-de-Almeida, Emerson S. Narciso, Flávio R. Puga