Action of aureomycin on the experimental fever in guinea pigs. Its effect on riquettsia isolated in São Paulo, after making it suitable for being injected by parenteral route.
Vol. 11 No. 1-2 (1951), ORIGINAL ARTICLE
Vol. 11 No. 1-2 (1951)

Action of aureomycin on the experimental fever in guinea pigs. Its effect on riquettsia isolated in São Paulo, after making it suitable for being injected by parenteral route.

ORIGINAL ARTICLE
https://doi.org/10.53393/rial.1951.11.33214
Published 1951-01-29
J. J. de Macedo
Instituto Butantan, São Paulo, SP
C. Haberbeck Brandão
Instituto Adolfo Lutz, São Paulo, SP
E. Lemos Monteiro
Instituto Adolfo Lutz, São Paulo, SP
PDF (Português (Brasil))

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1.
Macedo JJ de, Brandão CH, Monteiro EL. Action of aureomycin on the experimental fever in guinea pigs. Its effect on riquettsia isolated in São Paulo, after making it suitable for being injected by parenteral route. Rev Inst Adolfo Lutz [Internet]. 1951 Jan. 29 [cited 2024 May 18];11(1-2):159-66. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/33214
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Abstract

In experimental works on guinea-pigs, it is the parenteral administration of drugs which offers most commodity and security. The use of aureomycin by this route has certain disadvantages and inconveniencies which do not recommend it. The adaptation made by the authors, however, of the antibiotic which was originally destined for enteral application, permitted the perfect utilization of the parenteral route, by eliminating undesirable reactions. By applying a single or fractioned dose they were able to show the preventive or curative efficacy of aureomycin, after adaptation to parenteral use on experimental spotted fever in guinea-pigs which had been infected with rickettsias isolated in São Paulo.

https://doi.org/10.53393/rial.1951.11.33214
PDF (Português (Brasil))

References

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Copyright (c) 1951 Instituto Adolfo Lutz Journal

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