How to Cite
Abstract
In experimental works on guinea-pigs, it is the parenteral administration of drugs which offers most commodity and security. The use of aureomycin by this route has certain disadvantages and inconveniencies which do not recommend it. The adaptation made by the authors, however, of the antibiotic which was originally destined for enteral application, permitted the perfect utilization of the parenteral route, by eliminating undesirable reactions. By applying a single or fractioned dose they were able to show the preventive or curative efficacy of aureomycin, after adaptation to parenteral use on experimental spotted fever in guinea-pigs which had been infected with rickettsias isolated in São Paulo.
References
1. ANIGSTEIN,L., D. M. WHlTNEY e J. BENINSON- 1948 - Aureomycin - A new antibiotic with antirickettsial properties: its effects on experimental spotted fever and epidemic typhus. Ann. N. Y. Acad. Sci. 51: 306-317.
2. DRYER, M. S., E. B. SCHOENBACH,E. A. BLISS e C. A. CHANDLER- 1948 - Treatement of experimental infections with aureomycin. Ann. N. Y. Acad. Sci. 51 : 254-266.
3. COLLINS,H. S., T. F. PAINE e M. FINLAND- 1948 - Clinical studies with aureomycin. Ann. N. Y. Sci. 51: 231-240.
4. DOWLING, H. F., M. H. LEPPER, L. K. SWEET e R. L. BRICKHOUSE- 1948 - Studies on serum concentrations in human and prelirninary observations on the treatment of human infections with aureomycin. Ann. N. Y. Acad. Sci. 51: 241-245.
5. HARNED, B. K., R. W. CUNNINGHAM:,M. C. CLARK, R. COSGROVE,C. H. HINE, WM. MCCAULEY, E. STOKEY, R. E. VESSEY, N. N. YUDA e Y. SUBBAROW- 1948 - The pharmacology of duomycin, Ann. N. Y. Acad. Sci. 51: 182-210.
6. LENNETTE, E. H., G. MEIKLEJOHN e H. M. THELEN - 1948 - Treatement of Q fever in man with aureomycin. Ann. N. Y. Acad. Sci. 51: 331-342.
7. SCHOENBACH,E. B., S. BRYER MORTONe PERRIN H. LONG- 1948 - The pharmacology and clinical trial of aureomycin : a preliminary reporto Ann. N. Y. Acad. Sci. 51: 267-279.
8. TOLEDO PIZA, J., J. J. MACEDO,E. LEMOS MONTEIRO,C. H. BRANDÃO e L. P. BARRETO NETO - 1950 - Associação da aureomicina utilizada por via muscular e da cloromicetina por via oral, no tratamento da febre maculosa. Considerações sõbre os resultados obtidos pelo emprêgo da aureomicina purificada para utilização parenteral. Rev. Inst. Adolfo Lutz 10: 35-48.
9. WONG, SAN C. e HERALDR. Cox - 1948 - Action of aureomycin against experimental rickettsial and viral infections. Ann. N. Y. Acad. Sci. 51: 290-305.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 1951 Instituto Adolfo Lutz Journal