Palavras-chave
hidrocarbonetos policíclicos aromáticos
contaminantes
defumação
produtos cárneos
métodos de análise
contaminantes
defumação
produtos cárneos
métodos de análise
Como Citar
1.
de Queiroz Mozaner L, Palma de Almeida A, Alves da Silva S. Hidrocarbonetos policíclicos aromáticos: uma revisão sobre metodologias de análise e níveis de contaminação em produtos cárneos defumados . Rev Inst Adolfo Lutz [Internet]. 29º de março de 2019 [citado 21º de novembro de 2024];78(1):1-21. Disponível em: https://periodicos.saude.sp.gov.br/RIAL/article/view/34697
Resumo
A defumação é um processo rotineiramente empregado nos alimentos como técnica de conservação, e uma maneira de proporcionar as características sensoriais específicas. Entretanto, o processo pode levar à formação de hidrocarbonetos policíclicos aromáticos (HPAs), que são compostos com dois ou mais anéis aromáticos condensados, alguns deles considerados carcinogênicos, mutagênicos e teratogênicos. Estudos em diversos países indicam que a contaminação de produtos cárneos defumados por diferentes HPAs é elevada e frequente, e desta maneira pode apresentar risco à saúde humana. O Brasil tem sido um dos maiores consumidores de carne no mundo, com tendência de aumentar o consumo de alimentos processados, e não é conhecida a real exposição da população aos HPAs pela ingestão de produtos cárneos defumados. Não há dados nacionais recentes quanto à contaminação destes alimentos com estes produtos. Considerando este panorama, o presente trabalho tem como objetivo realizar a revisão das principais metodologias analíticas, dos aspectos regulatórios e dos níveis de HPAs detectados em produtos cárneos defumados. Ademais, são apresentadas as maneiras de reduzir a contaminação dos alimentos por estes compostos.
Referências
1. Lawal AT. Polycyclic aromatic hydrocarbons. A review. Cogent Environ Sci. 2017;3(1):1339841. https://doi.org/10.1080/23311843.2017.1339841
2. Abdel-Shafy HI, Mansour MSM. A review on polycyclic aromatic hydrocarbons: source, environmental impact, effect on human health and remediation. Egypt J Petrol. 2016;25(1):107-23. https://doi.org/10.1016/j.ejpe.2015.03.011
3. International Agency for Research on Cancer (IARC). Monographs on the evaluation of the carcinogenic risk of chemicals to humans, overall evaluation of carcinogenicity. Some Non-heterocyclic Polycyclic aromatic hydrocarbons and some related exposures. V. 92. Lyon: IARC; 2010.
4. International Agency for Research on Cancer (IARC). Monographs on the evaluation of the carcinogenic risk of chemicals to humans, overall evaluation of carcinogenicity. Chemical agents and related occupations. 100F. Lyon: IARC; 2012.
5. Purcaro G, Moret S, Conte LS. Overview on polycyclic aromatic hydrocarbons: occurrence, legislation and innovative determination in foods. Talanta, 2013;105:292-305. https://doi.org/10.1016/ j.talanta.2012.10.041
6. Domingo JL, Nadal M. Human dietary exposure to polycyclic aromatic hydrocarbons: a review of the scientific literature. Food Chem Toxicol. 2015;86: 144-53. https://doi.org/10.1016/j.fct.2015.10.002
7. Garcia LPA, Gonçalves BL, Scussel VM. Hidrocarbonetos policíclicos aromáticos em alimentos: uma revisão. PUBVET. 2014;8(19):2292-450.
8. Empresa Brasileira de Pesquisa Agropecuária - EMBRAPA. EMBRAPA suínos e aves [Internet]. Santa Catarina, 2016. [acesso 2018 Ago 26]. Disponível em: https://www.embrapa.br/suinos-eaves/cias/estatisticas
9. Pesquisa de orçamentos familiares 2008–2009: análise do consumo alimentar pessoal no Brasil/IBGE, Coordenação de Trabalho e Rendimento [Internet]. Rio de Janeiro (RJ): IBGE; 2011. [acesso 2018 Ago 26]. Disponível em: https://biblioteca.ibge.gov.br/ visualizacao/livros/liv50063.pdf
10. Morado CN. Avaliação da qualidade ambiental da bacia do rio Paraíba do Sul e reservatório do Funil, sudeste, Brasil, utilizando biomarcadores e bioindicadores em peixes. [dissertação de mestrado]. Rio de Janeiro: Universidade Federal Rural do Rio de Janeiro;2008. Disponível em: https://tede.ufrrj.br/ jspui/handle/tede/192
11. Netto ADP, Moreira JC, Dias AEXO, Arbilla G, Ferreira LFV, Oliveira AS et al. Avaliação da contaminação humana por hidrocarbonetos policíclicos aromáticos (HPAs) e seus derivados nitrados (NHPAs): uma revisão metodológica. Quim Nova. 2000;23(6):765-73. http://dx.doi.org/10.1590/ S0100-40422000000600010
12. Villar-Navarro M, Martín-Valero MJ, FernándezTorres RM, Callejón-Mochón M, Bello-López MA. Easy, fast and environmental friendly method for the simultaneous extraction of the 16 EPA PAHs using magnetic molecular imprinted. J Chromatogr B. 2017; 1044/1045:63-9. http://dx.doi.org/10.1016/ j.jchromb.2016.12.009
13. Kim KH, Jahan SA, Kabir E. Brown RJC. A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects. Environ Int. 2013;60:71-80. http://dx.doi.org/10.1016/j.envint.2013.07.019
14. Strickland P, Kang D. Urinary 1-hydroxypyrene and other PAH metabolites as biomarkers of exposure
to environmental PAH in air particulate matter. Toxicol Lett. 1999;108(2-3):191-9. http://dx.doi.org/ 10.1016/S0378-4274(99)00089-2
15. Tsai P, Shieh HY, Lee WJ, Lai SO. Characterization of PAHs in the atmosphere of carbon black manufacturing workplaces. J Hazard Mater. 2002;91(1-3):25-42.
http://dx.doi.org/10.1016/S0304-3894(01)00384-3
16. Tsai PJ, Shih TS, Chen HL, Lee WJ, Lai CH, Liou SH. Assessing and predicting the exposures of polycyclic aromatic hydrocarbons (PAHs) and their carcinogenic potencies from vehicle engine exhausts to highway toll station workers. Atmos Environ. 2004;38(2):33343. http://dx.doi.org/10.1016/j.atmosenv.2003.08.038
17. Azeredo A, Toledo MCF, Camargo MCR. Determinação de benzo(a)pireno em pescados. Ciênc Tecnol Aliment. 2006;26(1):89-93. http://dx.doi.org/ 10.1590/S0101-20612006000100015
18. Azeredo M. Determinação de benzo(a)pireno em pescados comercializados em CampinasSP. [dissertação de mestrado]. Campinas (SP): Universidade Estadual de Campinas;2001. Disponível em: http://repositorio.unicamp.br/jspui/handle/ REPOSIP/254999
19. Silva SAD, Sampaio GR, Torres EAFDS. Optimization and validation of a method using UHPLCfluorescence for the analysis of polycyclic aromatic hydrocarbons in cold-pressed vegetable oils. Food Chem. 2017;221:809-14. https://doi.org/10.1016/ j.foodchem.2016.11.098
20. Singh L,Varshney JG, Agarwal T. Polycyclic aromatic hydrocarbons’ formation and occurrence in processed food. Food Chem. 2016; 199:768-81. http://dx.doi.org/ 10.1016/j.foodchem.2015.12.074
21. Chávez IPA. Dos teores de hidrocarbonetos policíclicos aromáticos (HPAs) em aguardentes acondicionadas em tonéis de carvalho. [dissertação de mestrado]. São Carlos (SP): Universidade de São Paulo;2015. Dispinível em: https://teses.usp.br/teses/disponiveis/75/75135/ tde-16062015-092624/pt-br.php
22. Rose M, Holland J, Dowding A, Petch S, White S, Fernandes A et al. Investigation into the formation of PAHs in foods prepared in the home to determine the effects of frying, grilling, barbecuing, toasting and roasting. Food Chem Toxicol. 2015;78:1-9. http://dx.doi.org/10.1016/j.fct.2014.12.018
23. Martorell I, Perelló G, Martí-Cid R, Castell V, Llobet JM, Domingo JL. Polycyclic aromatic hydrocarbons (PAH) in foods and estimated PAH intake by the population of Catalonia, Spain: temporal trend. Environ Int. 2010;36(5):424-32. http://dx.doi.org/10.1016/ j.envint.2010.03.003
24. Sun Y, Wu S, Gong G. Trends of research on polycyclic aromatic hydrocarbons in food: a 20-year perspective from 1997 to 2017. Trends Food Sci Technol. 2019;83:86-98. http://dx.doi.org/10.1016/ j.tifs.2018.11.015
25. Ledesma E, Rendueles M, Díaz M. Spanish smoked meat products: benzo(a)pyrene (BaP) contamination and moisture. J Food Compost Anal. 2015;37:87-94. http://dx.doi.org/10.1016/j.jfca.2014.09.004
26. Ghasemzadeh-Mohammadi V, Mohammadi A, Hashemi M, Khaksar R, Haratian P. Microwaveassisted extraction and dispersive liquid–liquid microextraction followed by gas chromatography– mass spectrometry for isolation and determination of polycyclic aromatic hydrocarbons in smoked fish. J Chromatogr A. 2012;1237:30-6. http://dx.doi.org/10.1016/j.chroma.2012.02.078
27. Silva JH. Aspectos tecnológicos relacionados à fabricação de bacon [trabalho de conclusão]. Porto Alegre (RS): Universidade Federal do Rio Grande Do Sul;2010. Disponível em: https://lume.ufrgs.br/ handle/10183/28414
28. Ledesma E, Rendueles M, Díaz M. Contamination of meat products during smoking by polycyclic aromatic hydrocarbons: Processes and prevention. Food Control. 2016;60:64-87. http://dx.doi.org/10.1016/ j.foodcont.2015.07.016
29. Skaljac S, Petrovic L, Tasic T, Lkonic P, Jokanovic M, Tomovic V et al. Influence of smoking in traditional and industrial conditions on colour and content of polycyclic aromatic hydrocarbons in dry fermented sausage “Petrovská klobása” from Serbia. Food Control. 2014;40:12-8. http://dx.doi.org/10.1016/ j.foodcont.2013.11.024
30. Alakali JS, Adekoyeni OO, Alaka IC, Faasema J, Torvor T. Fabrication and performance evaluation of a hybrid fish smoking kiln. J Food Process Preserv. 2016;41:e12935. https://doi.org/10.1111/jfpp.12935
31. Stumpe-Viksna I, Bartkevics V, Kukare A, Morozovs A. Polycyclic aromatic hydrocarbons in meat smoked with different types of wood. Food Chem. 2008;110(3):794-7. http://dx.doi.org/10.1016/j.foodchem.2008.03.004
32. Commission of the European Communities. Commission Regulation (EC) No 2065/2003 of the European Parliament and of the Council of 10 November 2003 on smoke flavourings used or intended for use in or on foods. Official J Eur Union. 2003;L309:1-8.
33. Commission of the European Communities. Regulation (EC) No 1881/2006 of Comission of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Official J Eur Union. 2006;L364:5-24.
34. European Food Safety Authority (EFSA). Scientific opinion of the panel on contaminants in the food chain on a request from the european commission on PAHs in food. Eur Food Safety Authority J. 2008; 724:1-114.
35. Commission of the European Communities. Regulation (EC) No 835/2011 of Comission of 19 August 2011 amending Regulation (EC) No 1881/2006 as regards maximum levels for polycyclic aromatic hydrocarbons in foodstuffs. Official J Eur Union. 2011;L215:4-8.
36. Commission of the European Communities. Regulation (EC) No 1327/2014 of Comission of 12 December 2014 amending Regulation (EC) No 1881/2006 s regards maximum levels of polycyclic aromatic hydrocarbons (PAHs) in traditionally smoked meat and meat products and traditionally smoked fish and fishery products. Official J Eur Union. 2014;L358:13-4.
37. Ministério da Saúde (BR). Agência Nacional de Vigilância Sanitária. Resolução RDC nº 2, de 15 de janeiro de 2007. Regulamento técnico sobre aditivos aromatizantes. Diário Oficial da União, Brasília, DF, 15 jan 2007. Disponível em: http://portal.anvisa. gov.br/documents/10181/2718376/RDC_02_2007_ COMP.pdf/c966caff-1c19-4a2f-87a6-05f7a09e940b
38. Ministério da Saúde (BR). Agência Nacional de Vigilância Sanitária. Portaria de Consolidação nº 5, de 28 de setembro de 2017. Consolidação das normas sobre as ações e os serviços de saúde do Sistema Único de Saúde. Diário Oficial da União, Brasília, DF, 03 out 2017. Disponível em: https://portalarquivos2. saude.gov.br/images/pdf/2018/marco/29/ PRC-5-Portaria-de-Consolida----o-n---5-- de-28-de-setembro-de-2017.pdf
39. Ministério da Saúde (BR). Agência Nacional de Vigilância Sanitária. Resolução RDC nº 281, de 06 de outubro de 2003. Diário Oficial da União, Brasília, DF, 08 out. 2003. Disponível em: http://portal. anvisa.gov.br/documents/33916/393845/Resolucao_ RDC_n_281_de_06_de_outubro_de_2003.pdf/ 37e5b459-5f82-4a8b-8da7-ba29d4408174/
40. Association of Official Analytical Chemistry (AOAC). Official Methods of Analysis. AOAC 973.30. Polycyclic aromatic hydrocarbons and benzo[a] pyrene in food. 20th. Washington (DC): Association of Analytical Chemists;2015.
41. Djinovic J, Popovic, A, Jira, W. Polycyclic aromatic hydrocarbons (PAHs) in different types of smoked meat products from Serbia. Meat Sci. 2008;80(2):44956. http://dx.doi.org/10.1016/j.meatsci.2008.01.008
42. Purcaro G, Moret S, Conte LS. Optimisation of microwave assisted extraction (MAE) for polycyclic aromatic hydrocarbon (PAH) determination in smoked meat. Meat Sci. 2009;81(1):275-80.
https://doi.org/10.1016/j.meatsci.2008.08.002
43. Gómez-Ruiz JA, Cordeiro F, López P, Wenzl T. Optimisation and validation of programmed temperature vaporization (PTV) injection in solvent vent mode for the analysis of the 15+1 EU-priority PAHs by GC–MS. Talanta. 2009;80(2):643-50. http://dx.doi.org/10.1016/j.talanta.2009.07.041
44. Farhadian A, Jinap S, Hanifah HN, Zaidul IS. Effects of meat preheating and wrapping on the levels of polycyclic aromatic hydrocarbons in charcoalgrilled meat. Food Chem. 2011;124(1):141-6. http://dx.doi.org/10.1016/j.foodchem.2010.05.116
45. Roseiro LC, Gomes A, Santos C. Influence of processing in the prevalence of polycyclic aromatic hydrocarbons in a Portuguese traditional meat product. Food Chem Toxicol. 2011;49(6):1340-5. http://dx.doi.org/10.1016/j.fct.2011.03.017
46. Chung SY, Yettella RR, Kim JS, Kwon K, Kim MC, Min DB. Effects of grilling and roasting on the levels of polycyclic aromatic hydrocarbons in
beef and pork. Food Chem. 2011;129(4):1420-6. http://dx.doi.org/10.1016/j.foodchem.2011.05.092
47. Jahurul MHA, Jinap S, Zaidul ISM, Sahena F, Farhadian A, Hajeb P. Determination of fluoranthene, benzo[b]fluoranthene and benzo[a]pyrene in meat and fish products and their intake by Malaysian. Food Biosci. 2013;1:73-80. http://dx.doi.org/10.1016/ j.fbio.2013.03.006
48. Kumosani TA, Moselhy SS, Asseri AM, Asser AH. Detection of polycyclic aromatic hydrocarbons in different types of processed foods. Toxicol Ind Health. 2013;29(3):300-4. http://dx.doi.org/ 10.1177/0748233711433936
49. Olatunji OS, Fatoki OS, Opeolu BO, Ximba BJ. Determination of polycyclic aromatic hydrocarbons [PAHs] in processed meat products using gas chromatography – Flame ionization detector. Food Chem. 2014;156:296-300. http://dx.doi.org/10.1016/ j.foodchem.2014.01.120
50. Chen Y, Shen G, Su S, Shen H, Huang Y, Li T et al. Contamination and distribution of parent, nitrated, and oxygenated polycyclic aromatic hydrocarbons in smoked meat. Environ Sci Pollut Res Int. 2014;21(19):11521-30. http://dx.doi.org/10.1007/ s11356-014-3129-8
51. Surma M, Sadowska-Rociek A, Cieslik E. The application of d-SPE in the QuEChERS method for the determination of PAHs in food of animal origin with GC–MS detection. Eur Food Res Technol. 2014;238(6):1029-36. https://doi.org/10.1007/ s00217-014-2181-4
52. Association of Official Analytical Chemistry (AOAC). Official Methods of Analysis. AOAC 2014.08. Polycyclic aromatic hydrocarbons (PAHs) in Seafood. 20th. Washington (DC): Association of Analytical Chemists; 2015.
53. Khorshid M, Souaya ER, Hamzawy AH, Mohammed MN. QuEChERS Method followed by solid phase extraction method for gas chromatographic-mass spectrometric. Determination of polycyclic aromatic hydrocarbons in fish. Int J Anal Chem. 2015;2015:
ID 352610. https://doi.org/10.1155/2015/352610
54. Chatterjee NS, Utture S, Banerjee K, Shabeer TA, Kamble N, Mathew S et al. Multiresidue analysis of multiclass pesticides and polyaromatic hydrocarbons in fatty fish by gas chromatography tandem mass spectrometry and evaluation of matrix effect. Food Chem. 2016;196:1-8. https://doi.org/10.1016/j.foodchem.2015.09.014
55. Zachara A, Galkowska D, Juszczak L. Contamination of smoked meat and fish products from Polish market with polycyclic aromatic hydrocarbons. Food Control. 2017;80:45-51. https://doi.org/10.1016/j.foodcont.2017.04.024
56. Lu F, Kuhnle GK, Cheng Q. Heterocyclic amines and polycyclic aromatic hydrocarbons in commercial ready-to-eat meat products on UK market. Food Control. 2017;73(B):306-15. https://doi.org/10.1016/j.foodcont.2016.08.021
57. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO). Orientação sobre validação de métodos de ensaios químicos. DOQCGRE-008. Revisão 7, 2018. [acesso 2018 Ago 27]. Disponível em: http://www.inmetro.gov.br/ credenciamento/organismos/doc_organismos.asp? tOrganismo=CalibEnsaios
58. Zelinkova Z, Wenzl T. The Occurrence of 16 EPA PAHs in food – a review. Polycycl Aromat Compd. 2015;35(2-4):248-84. https://doi.org/10.1080/ 10406638.2014.918550
59. National Institute of Standards and Technology (NIST). Standard Reference materials. SRM 1974. 2018. [acesso 2018 Ago 27]. Disponível em: https://www-s.nist.gov/ srmors/view_detail.cfm?srm=1974
60. National Institute of Standards and Technology (NIST). Standard Reference materials. SRM 2974a. 2018. [acesso 2018 Ago 27]. Disponível em: https://www-s.nist.gov/ srmors/view_detail.cfm?srm=2974a
61. Grimmer G, Bohnke H. Polycyclic aromatic hydrocarbon profile of high-protein foods, oils, and fats by gas chromatography. J Assoc Off Anal Chem. 1975;58(4):725-33.
62. Brasseur C, Brose F, Pirlot A, Douny C, Eppe G, Maghuin-Rogister G. Validation of the analytical procedure for the determination of polyaromatic hydrocarbons in smoke flavourings using high performance liquid chromatography coupled
to an ultraviolet, diode array or fluorescence detector. Accred Qual Assur. 2007;12(10):535-42. https://doi.org/10.1007/s00769-007-0295-0
63. Kim L, Lee D, Cho HK, Choi SD. Review of the QuEChERS method for the analysis of organic pollutants: persistent organic pollutants, polycyclic aromatic hydrocarbons, and pharmaceuticals. Trends Environ Anal Chem. 2019;22:e00063. https://doi.org/10.1016/j.teac.2019.e00063
64. Part of avantor- VWR. Cromatografia, colunas- extração líquido-líquido Extrelut. [acesso 2018 Ago 27]. Disponível em: https://pt.vwr.com/store/ product/551127/extraccao-liquido-liquido-extrelut-nt
65. Kumar S, Negi S, Maiti P. Biological and analytical techniques used for detection of polyaromatic hydrocarbons. Environ Sci Pollut Res Int. 2017;24(33):25810–27. https://doi.org/10.1007/ s11356-017-0415-2
66. Joseph M. HPLC detector options for the determination of polynuclear aromatic hydrocarbons. Varian Application Note. [acesso 2018 Ago 27]. Disponível em: https://www.agilent.com/cs/library/ applications/lc07.pdf
67. Wretling S, Eriksson A, Eskhult GA, Larsson B. Polycyclic aromatic hydrocarbons (PAHs) in swedish smoked meat and fish. J Food Compost Anal. 2010;23(3):264-72. https://doi.org/10.1016/ j.jfca.2009.10.003
68. Bogdanović T, Pleadin J, Petričević S, Listeš E, Sokolić D, Marković K et al. The occurrence of polycyclic aromatic hydrocarbons in fish and meat products of Croatia and dietary exposure. J Food Compost Anal. 2019;75:49-60. https://doi.org/10.1016/ j.jfca.2018.09.017
69. Camargo RMC, Toledo MCF. Dietary polycyclic aromatic hydrocarbon intakes in some Brazilian metropolitan areas. Rev Bras Toxicol. 2001;14(2):23-30.
70. Lorenzo JM, Purriños L, Fontán MCG, Franco D. Polycyclic aromatic hydrocarbons (PAHs) in two spanish traditional smoked sausage varieties: “Androlla” and “Botillo”. Meat Sci. 2010;86(3):660-4. https://doi.org/10.1016/j.meatsci.2010.05.032
2. Abdel-Shafy HI, Mansour MSM. A review on polycyclic aromatic hydrocarbons: source, environmental impact, effect on human health and remediation. Egypt J Petrol. 2016;25(1):107-23. https://doi.org/10.1016/j.ejpe.2015.03.011
3. International Agency for Research on Cancer (IARC). Monographs on the evaluation of the carcinogenic risk of chemicals to humans, overall evaluation of carcinogenicity. Some Non-heterocyclic Polycyclic aromatic hydrocarbons and some related exposures. V. 92. Lyon: IARC; 2010.
4. International Agency for Research on Cancer (IARC). Monographs on the evaluation of the carcinogenic risk of chemicals to humans, overall evaluation of carcinogenicity. Chemical agents and related occupations. 100F. Lyon: IARC; 2012.
5. Purcaro G, Moret S, Conte LS. Overview on polycyclic aromatic hydrocarbons: occurrence, legislation and innovative determination in foods. Talanta, 2013;105:292-305. https://doi.org/10.1016/ j.talanta.2012.10.041
6. Domingo JL, Nadal M. Human dietary exposure to polycyclic aromatic hydrocarbons: a review of the scientific literature. Food Chem Toxicol. 2015;86: 144-53. https://doi.org/10.1016/j.fct.2015.10.002
7. Garcia LPA, Gonçalves BL, Scussel VM. Hidrocarbonetos policíclicos aromáticos em alimentos: uma revisão. PUBVET. 2014;8(19):2292-450.
8. Empresa Brasileira de Pesquisa Agropecuária - EMBRAPA. EMBRAPA suínos e aves [Internet]. Santa Catarina, 2016. [acesso 2018 Ago 26]. Disponível em: https://www.embrapa.br/suinos-eaves/cias/estatisticas
9. Pesquisa de orçamentos familiares 2008–2009: análise do consumo alimentar pessoal no Brasil/IBGE, Coordenação de Trabalho e Rendimento [Internet]. Rio de Janeiro (RJ): IBGE; 2011. [acesso 2018 Ago 26]. Disponível em: https://biblioteca.ibge.gov.br/ visualizacao/livros/liv50063.pdf
10. Morado CN. Avaliação da qualidade ambiental da bacia do rio Paraíba do Sul e reservatório do Funil, sudeste, Brasil, utilizando biomarcadores e bioindicadores em peixes. [dissertação de mestrado]. Rio de Janeiro: Universidade Federal Rural do Rio de Janeiro;2008. Disponível em: https://tede.ufrrj.br/ jspui/handle/tede/192
11. Netto ADP, Moreira JC, Dias AEXO, Arbilla G, Ferreira LFV, Oliveira AS et al. Avaliação da contaminação humana por hidrocarbonetos policíclicos aromáticos (HPAs) e seus derivados nitrados (NHPAs): uma revisão metodológica. Quim Nova. 2000;23(6):765-73. http://dx.doi.org/10.1590/ S0100-40422000000600010
12. Villar-Navarro M, Martín-Valero MJ, FernándezTorres RM, Callejón-Mochón M, Bello-López MA. Easy, fast and environmental friendly method for the simultaneous extraction of the 16 EPA PAHs using magnetic molecular imprinted. J Chromatogr B. 2017; 1044/1045:63-9. http://dx.doi.org/10.1016/ j.jchromb.2016.12.009
13. Kim KH, Jahan SA, Kabir E. Brown RJC. A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects. Environ Int. 2013;60:71-80. http://dx.doi.org/10.1016/j.envint.2013.07.019
14. Strickland P, Kang D. Urinary 1-hydroxypyrene and other PAH metabolites as biomarkers of exposure
to environmental PAH in air particulate matter. Toxicol Lett. 1999;108(2-3):191-9. http://dx.doi.org/ 10.1016/S0378-4274(99)00089-2
15. Tsai P, Shieh HY, Lee WJ, Lai SO. Characterization of PAHs in the atmosphere of carbon black manufacturing workplaces. J Hazard Mater. 2002;91(1-3):25-42.
http://dx.doi.org/10.1016/S0304-3894(01)00384-3
16. Tsai PJ, Shih TS, Chen HL, Lee WJ, Lai CH, Liou SH. Assessing and predicting the exposures of polycyclic aromatic hydrocarbons (PAHs) and their carcinogenic potencies from vehicle engine exhausts to highway toll station workers. Atmos Environ. 2004;38(2):33343. http://dx.doi.org/10.1016/j.atmosenv.2003.08.038
17. Azeredo A, Toledo MCF, Camargo MCR. Determinação de benzo(a)pireno em pescados. Ciênc Tecnol Aliment. 2006;26(1):89-93. http://dx.doi.org/ 10.1590/S0101-20612006000100015
18. Azeredo M. Determinação de benzo(a)pireno em pescados comercializados em CampinasSP. [dissertação de mestrado]. Campinas (SP): Universidade Estadual de Campinas;2001. Disponível em: http://repositorio.unicamp.br/jspui/handle/ REPOSIP/254999
19. Silva SAD, Sampaio GR, Torres EAFDS. Optimization and validation of a method using UHPLCfluorescence for the analysis of polycyclic aromatic hydrocarbons in cold-pressed vegetable oils. Food Chem. 2017;221:809-14. https://doi.org/10.1016/ j.foodchem.2016.11.098
20. Singh L,Varshney JG, Agarwal T. Polycyclic aromatic hydrocarbons’ formation and occurrence in processed food. Food Chem. 2016; 199:768-81. http://dx.doi.org/ 10.1016/j.foodchem.2015.12.074
21. Chávez IPA. Dos teores de hidrocarbonetos policíclicos aromáticos (HPAs) em aguardentes acondicionadas em tonéis de carvalho. [dissertação de mestrado]. São Carlos (SP): Universidade de São Paulo;2015. Dispinível em: https://teses.usp.br/teses/disponiveis/75/75135/ tde-16062015-092624/pt-br.php
22. Rose M, Holland J, Dowding A, Petch S, White S, Fernandes A et al. Investigation into the formation of PAHs in foods prepared in the home to determine the effects of frying, grilling, barbecuing, toasting and roasting. Food Chem Toxicol. 2015;78:1-9. http://dx.doi.org/10.1016/j.fct.2014.12.018
23. Martorell I, Perelló G, Martí-Cid R, Castell V, Llobet JM, Domingo JL. Polycyclic aromatic hydrocarbons (PAH) in foods and estimated PAH intake by the population of Catalonia, Spain: temporal trend. Environ Int. 2010;36(5):424-32. http://dx.doi.org/10.1016/ j.envint.2010.03.003
24. Sun Y, Wu S, Gong G. Trends of research on polycyclic aromatic hydrocarbons in food: a 20-year perspective from 1997 to 2017. Trends Food Sci Technol. 2019;83:86-98. http://dx.doi.org/10.1016/ j.tifs.2018.11.015
25. Ledesma E, Rendueles M, Díaz M. Spanish smoked meat products: benzo(a)pyrene (BaP) contamination and moisture. J Food Compost Anal. 2015;37:87-94. http://dx.doi.org/10.1016/j.jfca.2014.09.004
26. Ghasemzadeh-Mohammadi V, Mohammadi A, Hashemi M, Khaksar R, Haratian P. Microwaveassisted extraction and dispersive liquid–liquid microextraction followed by gas chromatography– mass spectrometry for isolation and determination of polycyclic aromatic hydrocarbons in smoked fish. J Chromatogr A. 2012;1237:30-6. http://dx.doi.org/10.1016/j.chroma.2012.02.078
27. Silva JH. Aspectos tecnológicos relacionados à fabricação de bacon [trabalho de conclusão]. Porto Alegre (RS): Universidade Federal do Rio Grande Do Sul;2010. Disponível em: https://lume.ufrgs.br/ handle/10183/28414
28. Ledesma E, Rendueles M, Díaz M. Contamination of meat products during smoking by polycyclic aromatic hydrocarbons: Processes and prevention. Food Control. 2016;60:64-87. http://dx.doi.org/10.1016/ j.foodcont.2015.07.016
29. Skaljac S, Petrovic L, Tasic T, Lkonic P, Jokanovic M, Tomovic V et al. Influence of smoking in traditional and industrial conditions on colour and content of polycyclic aromatic hydrocarbons in dry fermented sausage “Petrovská klobása” from Serbia. Food Control. 2014;40:12-8. http://dx.doi.org/10.1016/ j.foodcont.2013.11.024
30. Alakali JS, Adekoyeni OO, Alaka IC, Faasema J, Torvor T. Fabrication and performance evaluation of a hybrid fish smoking kiln. J Food Process Preserv. 2016;41:e12935. https://doi.org/10.1111/jfpp.12935
31. Stumpe-Viksna I, Bartkevics V, Kukare A, Morozovs A. Polycyclic aromatic hydrocarbons in meat smoked with different types of wood. Food Chem. 2008;110(3):794-7. http://dx.doi.org/10.1016/j.foodchem.2008.03.004
32. Commission of the European Communities. Commission Regulation (EC) No 2065/2003 of the European Parliament and of the Council of 10 November 2003 on smoke flavourings used or intended for use in or on foods. Official J Eur Union. 2003;L309:1-8.
33. Commission of the European Communities. Regulation (EC) No 1881/2006 of Comission of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Official J Eur Union. 2006;L364:5-24.
34. European Food Safety Authority (EFSA). Scientific opinion of the panel on contaminants in the food chain on a request from the european commission on PAHs in food. Eur Food Safety Authority J. 2008; 724:1-114.
35. Commission of the European Communities. Regulation (EC) No 835/2011 of Comission of 19 August 2011 amending Regulation (EC) No 1881/2006 as regards maximum levels for polycyclic aromatic hydrocarbons in foodstuffs. Official J Eur Union. 2011;L215:4-8.
36. Commission of the European Communities. Regulation (EC) No 1327/2014 of Comission of 12 December 2014 amending Regulation (EC) No 1881/2006 s regards maximum levels of polycyclic aromatic hydrocarbons (PAHs) in traditionally smoked meat and meat products and traditionally smoked fish and fishery products. Official J Eur Union. 2014;L358:13-4.
37. Ministério da Saúde (BR). Agência Nacional de Vigilância Sanitária. Resolução RDC nº 2, de 15 de janeiro de 2007. Regulamento técnico sobre aditivos aromatizantes. Diário Oficial da União, Brasília, DF, 15 jan 2007. Disponível em: http://portal.anvisa. gov.br/documents/10181/2718376/RDC_02_2007_ COMP.pdf/c966caff-1c19-4a2f-87a6-05f7a09e940b
38. Ministério da Saúde (BR). Agência Nacional de Vigilância Sanitária. Portaria de Consolidação nº 5, de 28 de setembro de 2017. Consolidação das normas sobre as ações e os serviços de saúde do Sistema Único de Saúde. Diário Oficial da União, Brasília, DF, 03 out 2017. Disponível em: https://portalarquivos2. saude.gov.br/images/pdf/2018/marco/29/ PRC-5-Portaria-de-Consolida----o-n---5-- de-28-de-setembro-de-2017.pdf
39. Ministério da Saúde (BR). Agência Nacional de Vigilância Sanitária. Resolução RDC nº 281, de 06 de outubro de 2003. Diário Oficial da União, Brasília, DF, 08 out. 2003. Disponível em: http://portal. anvisa.gov.br/documents/33916/393845/Resolucao_ RDC_n_281_de_06_de_outubro_de_2003.pdf/ 37e5b459-5f82-4a8b-8da7-ba29d4408174/
40. Association of Official Analytical Chemistry (AOAC). Official Methods of Analysis. AOAC 973.30. Polycyclic aromatic hydrocarbons and benzo[a] pyrene in food. 20th. Washington (DC): Association of Analytical Chemists;2015.
41. Djinovic J, Popovic, A, Jira, W. Polycyclic aromatic hydrocarbons (PAHs) in different types of smoked meat products from Serbia. Meat Sci. 2008;80(2):44956. http://dx.doi.org/10.1016/j.meatsci.2008.01.008
42. Purcaro G, Moret S, Conte LS. Optimisation of microwave assisted extraction (MAE) for polycyclic aromatic hydrocarbon (PAH) determination in smoked meat. Meat Sci. 2009;81(1):275-80.
https://doi.org/10.1016/j.meatsci.2008.08.002
43. Gómez-Ruiz JA, Cordeiro F, López P, Wenzl T. Optimisation and validation of programmed temperature vaporization (PTV) injection in solvent vent mode for the analysis of the 15+1 EU-priority PAHs by GC–MS. Talanta. 2009;80(2):643-50. http://dx.doi.org/10.1016/j.talanta.2009.07.041
44. Farhadian A, Jinap S, Hanifah HN, Zaidul IS. Effects of meat preheating and wrapping on the levels of polycyclic aromatic hydrocarbons in charcoalgrilled meat. Food Chem. 2011;124(1):141-6. http://dx.doi.org/10.1016/j.foodchem.2010.05.116
45. Roseiro LC, Gomes A, Santos C. Influence of processing in the prevalence of polycyclic aromatic hydrocarbons in a Portuguese traditional meat product. Food Chem Toxicol. 2011;49(6):1340-5. http://dx.doi.org/10.1016/j.fct.2011.03.017
46. Chung SY, Yettella RR, Kim JS, Kwon K, Kim MC, Min DB. Effects of grilling and roasting on the levels of polycyclic aromatic hydrocarbons in
beef and pork. Food Chem. 2011;129(4):1420-6. http://dx.doi.org/10.1016/j.foodchem.2011.05.092
47. Jahurul MHA, Jinap S, Zaidul ISM, Sahena F, Farhadian A, Hajeb P. Determination of fluoranthene, benzo[b]fluoranthene and benzo[a]pyrene in meat and fish products and their intake by Malaysian. Food Biosci. 2013;1:73-80. http://dx.doi.org/10.1016/ j.fbio.2013.03.006
48. Kumosani TA, Moselhy SS, Asseri AM, Asser AH. Detection of polycyclic aromatic hydrocarbons in different types of processed foods. Toxicol Ind Health. 2013;29(3):300-4. http://dx.doi.org/ 10.1177/0748233711433936
49. Olatunji OS, Fatoki OS, Opeolu BO, Ximba BJ. Determination of polycyclic aromatic hydrocarbons [PAHs] in processed meat products using gas chromatography – Flame ionization detector. Food Chem. 2014;156:296-300. http://dx.doi.org/10.1016/ j.foodchem.2014.01.120
50. Chen Y, Shen G, Su S, Shen H, Huang Y, Li T et al. Contamination and distribution of parent, nitrated, and oxygenated polycyclic aromatic hydrocarbons in smoked meat. Environ Sci Pollut Res Int. 2014;21(19):11521-30. http://dx.doi.org/10.1007/ s11356-014-3129-8
51. Surma M, Sadowska-Rociek A, Cieslik E. The application of d-SPE in the QuEChERS method for the determination of PAHs in food of animal origin with GC–MS detection. Eur Food Res Technol. 2014;238(6):1029-36. https://doi.org/10.1007/ s00217-014-2181-4
52. Association of Official Analytical Chemistry (AOAC). Official Methods of Analysis. AOAC 2014.08. Polycyclic aromatic hydrocarbons (PAHs) in Seafood. 20th. Washington (DC): Association of Analytical Chemists; 2015.
53. Khorshid M, Souaya ER, Hamzawy AH, Mohammed MN. QuEChERS Method followed by solid phase extraction method for gas chromatographic-mass spectrometric. Determination of polycyclic aromatic hydrocarbons in fish. Int J Anal Chem. 2015;2015:
ID 352610. https://doi.org/10.1155/2015/352610
54. Chatterjee NS, Utture S, Banerjee K, Shabeer TA, Kamble N, Mathew S et al. Multiresidue analysis of multiclass pesticides and polyaromatic hydrocarbons in fatty fish by gas chromatography tandem mass spectrometry and evaluation of matrix effect. Food Chem. 2016;196:1-8. https://doi.org/10.1016/j.foodchem.2015.09.014
55. Zachara A, Galkowska D, Juszczak L. Contamination of smoked meat and fish products from Polish market with polycyclic aromatic hydrocarbons. Food Control. 2017;80:45-51. https://doi.org/10.1016/j.foodcont.2017.04.024
56. Lu F, Kuhnle GK, Cheng Q. Heterocyclic amines and polycyclic aromatic hydrocarbons in commercial ready-to-eat meat products on UK market. Food Control. 2017;73(B):306-15. https://doi.org/10.1016/j.foodcont.2016.08.021
57. Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO). Orientação sobre validação de métodos de ensaios químicos. DOQCGRE-008. Revisão 7, 2018. [acesso 2018 Ago 27]. Disponível em: http://www.inmetro.gov.br/ credenciamento/organismos/doc_organismos.asp? tOrganismo=CalibEnsaios
58. Zelinkova Z, Wenzl T. The Occurrence of 16 EPA PAHs in food – a review. Polycycl Aromat Compd. 2015;35(2-4):248-84. https://doi.org/10.1080/ 10406638.2014.918550
59. National Institute of Standards and Technology (NIST). Standard Reference materials. SRM 1974. 2018. [acesso 2018 Ago 27]. Disponível em: https://www-s.nist.gov/ srmors/view_detail.cfm?srm=1974
60. National Institute of Standards and Technology (NIST). Standard Reference materials. SRM 2974a. 2018. [acesso 2018 Ago 27]. Disponível em: https://www-s.nist.gov/ srmors/view_detail.cfm?srm=2974a
61. Grimmer G, Bohnke H. Polycyclic aromatic hydrocarbon profile of high-protein foods, oils, and fats by gas chromatography. J Assoc Off Anal Chem. 1975;58(4):725-33.
62. Brasseur C, Brose F, Pirlot A, Douny C, Eppe G, Maghuin-Rogister G. Validation of the analytical procedure for the determination of polyaromatic hydrocarbons in smoke flavourings using high performance liquid chromatography coupled
to an ultraviolet, diode array or fluorescence detector. Accred Qual Assur. 2007;12(10):535-42. https://doi.org/10.1007/s00769-007-0295-0
63. Kim L, Lee D, Cho HK, Choi SD. Review of the QuEChERS method for the analysis of organic pollutants: persistent organic pollutants, polycyclic aromatic hydrocarbons, and pharmaceuticals. Trends Environ Anal Chem. 2019;22:e00063. https://doi.org/10.1016/j.teac.2019.e00063
64. Part of avantor- VWR. Cromatografia, colunas- extração líquido-líquido Extrelut. [acesso 2018 Ago 27]. Disponível em: https://pt.vwr.com/store/ product/551127/extraccao-liquido-liquido-extrelut-nt
65. Kumar S, Negi S, Maiti P. Biological and analytical techniques used for detection of polyaromatic hydrocarbons. Environ Sci Pollut Res Int. 2017;24(33):25810–27. https://doi.org/10.1007/ s11356-017-0415-2
66. Joseph M. HPLC detector options for the determination of polynuclear aromatic hydrocarbons. Varian Application Note. [acesso 2018 Ago 27]. Disponível em: https://www.agilent.com/cs/library/ applications/lc07.pdf
67. Wretling S, Eriksson A, Eskhult GA, Larsson B. Polycyclic aromatic hydrocarbons (PAHs) in swedish smoked meat and fish. J Food Compost Anal. 2010;23(3):264-72. https://doi.org/10.1016/ j.jfca.2009.10.003
68. Bogdanović T, Pleadin J, Petričević S, Listeš E, Sokolić D, Marković K et al. The occurrence of polycyclic aromatic hydrocarbons in fish and meat products of Croatia and dietary exposure. J Food Compost Anal. 2019;75:49-60. https://doi.org/10.1016/ j.jfca.2018.09.017
69. Camargo RMC, Toledo MCF. Dietary polycyclic aromatic hydrocarbon intakes in some Brazilian metropolitan areas. Rev Bras Toxicol. 2001;14(2):23-30.
70. Lorenzo JM, Purriños L, Fontán MCG, Franco D. Polycyclic aromatic hydrocarbons (PAHs) in two spanish traditional smoked sausage varieties: “Androlla” and “Botillo”. Meat Sci. 2010;86(3):660-4. https://doi.org/10.1016/j.meatsci.2010.05.032
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Copyright (c) 2019 Letícia de Queiroz Mozaner, Adriana Palma de Almeida, Simone Alves da Silva
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