Influência do controle glicêmico na hiperlipemia de mulheres diabéticas (tipo II)
pdf

Palavras-chave

Hiperglicemia
Hiperlipemia
Diabetes mellitus

Como Citar

1.
Martins HP, Oda M, Zamboni IM, Castilho LN. Influência do controle glicêmico na hiperlipemia de mulheres diabéticas (tipo II). Rev Inst Adolfo Lutz [Internet]. 30º de dezembro de 1994 [citado 20º de junho de 2024];54(2):121-5. Disponível em: https://periodicos.saude.sp.gov.br/RIAL/article/view/35705

Resumo

Estudamos os níveis séricos de glicose, HbAlc, alfa2 e beta globulinas em 46 mulheres entre 51 e 70 anos, para observar sua correlação com o perfil Iipídico no diabetes mellitus não insulino dependente, para tentar estabelecer uma associação entre a hiperlipemia e o controle glicêmico inadequado. Dentre os parâmetros estudados o colesterol total, o HDL-colesterol e os triglicérides se correlacionaram positivamente com a glicemia e as proteínas glicadas nos diabéticas tipo Il, o que pode ressaltar o efeito da hiperglicemia no metabolismo lipídico. No nosso estudo houve uma diminuição de 20% nos níveis de
HDL-CoI. nas mulheres diabéticas quando comparadas com o grupo controle não diabético. Este decréscimo se acentua com a obesidade. Estas diabéticas apresentaram um nível pouco alterado de colesterol total, com média geral de 243 mg/dl com um risco maior para os problemas cardiovasculares. Observamos também um aumento de 2 vezes a média dos níveis de triglicérides, quando comparados com a população controle de mesmo sexo, idade e peso semelhantes.

https://doi.org/10.53393/rial.1994.54.35705
pdf

Referências

1. ASSMAN, G. & SCHULTE, H.: "The Prospective Cardiovascular Munster (PROCAM) study: Prevalence of hiperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease". Am. Heart. J. 116: 1713-, 1988.

2. GARCIA, M.J., ET AL: "Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow up study". Diabetes 23: 105-, 1974.

3. KANNEL, W.B. & McGEE, D.L.: "Diabetics and cardiovascular disease. The Framingham Study", lama 241:2035-,1979.

4. GORDON T. ET AL.; "Diabetes, blood lipids, and the role of obesity in coronary heart disease risk for women. The Framingham study", Ann. Intern. Med. 83:393-, 1977.

5. BARRETT-CONNOR, E & WINGARD, D.L.: "Sex differential in ischemia heart disease mortality in diabetics: A prospective population-based study" Am.J.Epidemiol. 118:489-, 1983.

6. KROLEWSKI, A.S. ET AL. "Magnitude and determinants of coronary artery disease in juvenile-onset, insulin dependent diabetes mellitus". Am.J.Cardiol. 59:750-, 1987.

7. FONTBONNE, A. ET AL."Hypertriglyceridemia as a risk factor of coronary heart disease mortality in subjects with impaired glueose tolerande or diabetes; Results from the 1I -year follow-up of the Paris Prospeetive Study". Diabetologia 32:300-, 1989.

8. STANTEN, RJ. ET AL.: "Atherosclerosis in diabetes mellitus. Correlations with serum lipid levels, adiposity, and se rum insulin leveI". A rch.Intern.Med. 130: 833-, 1972.

9. VUSITUPA, M.I.J. ET AL.; "The relation-ship of cardiovascular risk faetors to the prevalence of coronary heart disease in newly diagnosed type 2 (non-insulin dependent) diabetes". Diabetologia 28: 653-, 1985.

10. VUSITUPA, M.I.J.: "Five-year incidenee of atherosclerotie vascular disease in relation to general risk factors, insulin leveI, and abnormalities in lipoprotein composition in non-insulin-dependente diabetie and non diabetie subjeets". Circulation 82:27-, 1990.

11. WEST, K.M. ET AL.: "The role of eireulating glueose and triglyeeride eoneentrations and their interactions with other "risk faetors"as determinatns of arterial disease in nine diabetic population samples from the WHO multinational study". Diabetes Care 6: 361-,1983.

12. LAAKSO, M. ET AL.: "Lipid and lipoprotein abnormalities associated with eoronary heart disease in patients with insulin-depcndent diabetes mellitus". Atheriosclerosis 6: 679-, 1986.

13. LAAKSO, M. ET AL.: "Assoeiation of low HDL and HDL-2-eholesterol with eoronary heart disease in non-insulin-dependent diabeties". Atheriosclerosis 5: 653-,1985.

14. BEACH, K.W. ET AL.: "The eorrelation of arteriosclerosis obliterans with lipoproteins in insulindependent and non-insulin-depcndcnt diabetes". Diabetes 28: 836, 1979.

15. WALDEN, C.E. ET AL.: "Sex differences in the effeet of diabetes mellitus on lipoprotein triglyeeride and eholesterol eoncentrations". N.Engl.J.Med. 311: 953-, 1984.

16. BERGMANN, M.; GIDEZ, L.I. & EDER, H.A.: "Highdensity lipoprotein subclasses in diabetes". Am.J.Med. 81 :488-1986.

17. BARRETT-CONNOR, E. WITZTUM, J. & HOLBROOK, M.; "A eommunity study of high density lipoproteins in adu1t noninsu1in-dependent diabetics". Am.LEpidemiol. 117:186-192,1983.

18. BASSO, L.V. & HAVEL, RJ.: "Hepatic metabo1ism of free fatty acids in normal and diabetic dogs", J. Clin.lnvest. 49:537- , 1970.

19. BARRETT-CONNOR, E.; GRUNDY, S.M. & HOLD-BROOK, M. "Plasma lipids and diabetes mellitus in an adu1t community". Am.J.Epidemiol. 115:657-, 1982.

20. BRIONES, E.R.; MAO, SJ.T. & PALUMBO, P.M.: "Analysis of plasma 1ipids and apolipoproteins in insulin- dependent and noninsu1in-dependent diabetes". Metabolism 33:42-,1984.

21. LAAKSO, M. & BARRETT-CONNOR, E.: "Asymptomatic hyperg1ycemia is associated with 1ipid and lipoprotein changes favoring atherosclerosis". Arteriosclerosis. 9:665-, 1989.

22. HOWARD B.V.; ET AL.: "Changes in plasma 1ipoproteins accompany dieta therapy in obese diabetics". Atherosclerosis 33:445-, 1979.

23. SOSENKO, 1.M. ET AL: "Hiperglycemia and plasma lipid 1eve1s. A prospective study of young insu1independent diabetic patients". N.Engl.J.Med. 302:650, 1980.

24. NIKKILA, E.A.: "High density 1ipoproteins in diabetes". Diabetes 30(supp1.2):82-, 1981.

25. ECKEL, R.H. ET AL.: "High density 1ipoprotein composition in insu1in-dependent diabetes mellitus". Diabetes 30: 132-, 1981.

26. PAISEY, R. ET AL.: "The effects of chlorpropamide and insu1in on serum 1ipids, lipoproteins and fractiona1 triglycerides removal". Diabetologia 15:81-, 1978.

27. TA YLOR, K.G. ET AL.: "A prospective study of the effects of 12 months treatment on serum lipids and apo1ipoproteins A-I and B in type 2 (noninsulindependent) diabetes. Diabetoiogia 23:507-, 1982.

28. KENNEDY, L. ET AL.: "The effect of intensive dietary therapy on serum high-density 1ipoprotein cholesterol in patients with type II (noninsulindependent) diabetes mellitus. A prospective study. Diabetologia 23: 24-,1982.

29. ABRAMS,J.; GINSBERG, H. &GRUNDY, S.: "Metabolism of cho1estero1 and plasma triglycerides in nonketotic diabetes mellitus". Diabetes 31:903-, 1982.

30. DUNN, FL. ET AL.: "The effect of diabetic control on very low-density lipoprotein triglyceride metabo1ism in patients with type II diabetes and marked hypertriglyceridemia". Metabolism 33: 117-1984.

31. KISSEBAH, A.H. ET AL.: "Plasma low-density lip protein transporte kinetics in noninsulin – dependent diabetes mellitus". J.Clin./nvest. 71:655,1983.

32. HOWARD, H.V. ET AL. "Very low density lipoprotein triglyceride metabolism in noninsulin-dependent diabetes mellitus. Relationship to plasma insu1in and free fatty acids. Diabetes 32:271-, 1983.

33. TASKINEN, M.R. ET AL.: "Effects of NIDDM on very-low-density lipoprotein trig1yceride and apolipoprotein B metabolismo Studies before and after sulfonylurea therapy". Diabetes 35: 1268-, 1986.

34. BRUNZEL, 1.D.; PORTE, DJ. & BTERMAN, E.L.: "Abnorrnal 1ipoprotein-lipase-mediated plasma triglyceride removal in untreated diabetes mellitus associated with hypertrigliceridemia". Metabolism 28:901-, 1979.

35. HAFFNER, S.M. ET AL.: "Retarded chylomicron apolipoprotein B catabolism in type 2 (non-insulindependent) diabetic subjetcs with Iipaemia". Diabetologia 26: 349-, 1984.

36. GARG, A. & GRUNDY, S.M.: "Nicotinic acid may not be first 1ine therapy for dyslipidemia in non insulin-dependent diabetes mellitus". Clin. Res. 37: 449-, 1989.

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

Copyright (c) 1994 H. P. Martins, M.Y.N. Oda, I. M. Zamboni, L. N. Castilho

Downloads

Não há dados estatísticos.