Palavras-chave
Medula óssea
Mielo-supressores
SIDA
Mielo-supressores
SIDA
Como Citar
1.
Barreto JA, Munhoz MAG. Estudo morfológico de aspirados de medula óssea em pacientes com Síndrome da Imunodeficiência Adquirida. Rev Inst Adolfo Lutz [Internet]. 30º de junho de 1994 [citado 9º de maio de 2024];54(1):55-63. Disponível em: https://periodicos.saude.sp.gov.br/RIAL/article/view/36533
Resumo
Entre junho e novembro de 1992,estudamos 42 aspirados de medula óssea de pacientes com Síndrome da Imunodeficiência Adquirida (SIDA), grupo IV-C (classificação CDC, 1986), para avaliarmos as alterações morfológicas, qualitativas e quantitativas, decorrentes desta síndrome. Os critérios clínicos para a realização dessas punções foram: febre persistente, anemia, leucopenia, trombocitopenia ou uma combinação dessas anormalidades. Na medula óssea encontramos predomínio de hipocelularidade (71,4%), alterações mielodisplásicas em todos os casos, eosinofilia (19,0%), plasmocitose (45,2%), linfopenia (21,4%) e macrófagos em número aumentado (16,7%). No sangue periférico observamos anemia (81,0%), leucopenia (59,5%), neutropenia (42,9%), linfopenia (88,0%), plaquetopenia (33,3%) e pancitopenia (38,0%). As causas dessas anormalidades são múltiplas: infecções oportunistas, medicamentos mielosupressores, mecanismos imunológicos e ação direta do HIV sobre células progenitoras da medula óssea e células maduras do sangue periférico.
Referências
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8. CENTERS FOR DISEASE CONTROL. Classification system for human T-lymphotropic virus type III/ lymphadenopathy-associated virus infections. Ann. Intern. Med. 105:234-237, 1986.
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13. D'ONOFRIO, G.; MANCINI, S.; TAMBURRINI, E.; MANGO, G. & ORTONA, L. - Giant neutrophils with increased peroxidase activity. Another evidence of dysgranulopoiesis in AIDS. Am. J. Clin. Pathol. 87:584-591, 1987.
14. DUARTE, M.I.S.; OLIVEIRA, M.S. SHIKANAIYASUDA, M.A. MARIANO, O.N.; TAKAKURA, C.F.H.; PAGLIARI, C. & CORBETT, C.E.P. - Haemobartonella-like microorganism infection in AIDS patients: ultrastructural pathology (letter). J. Infect. Dis. 165:976-977, 1992.
15. FARHI, D.C.; MASON, U.G. & HORSBURGH, C.R. - The bone marrow in disseminated Mycobacterium avium intracellulare infection. Am. J. Clin. Pathol. 83:463-468, 1985.
16. FERRERAS FERRERAS, B. - Neurosida (I): aspectos generales. Mapfre Med. 3:249-264, 1992.
17. FERRERAS FERRERAS, B. - Neurosida (II): Manifestaciones neurológicas del SIDA. Mapfre Med. 4:29- 47,1993.
18. FOLKS, T.M.; KESSLER, S.W.; ORENSTEIN, J.M.; JUSTEMENT, J.S.; JAFFE, E.S. & FAUCI, A.S. - Infection and replication of HIV -1 in purified progenitor cells of normal human bone marrow. Science. 242:919-922, 1988.
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20. FRANCO, C.M.; HENDRIX, L.F. & LOKEY, J.L. - Bone marrow abnormalities in the acquired immunodeficiency syndrome (letter). Ann. Inter. Med. 101:275-276, 1984.
21. FRONTIERA, M. & MYERS, A.M. - Peripheral blood and bone marrow abnormalities in the acquired immunodeficiency syndrome. West. J. Med. 147:157- 160, 1987.
22. GANSER, A. - Abnormalities of hematopoesis in the acquired immunodeficiency syndrome. Blut. 56:49-53, 1988.
23. GARDENER, T.D.; FLANAGAN, P.; DRYDEN, M.S.; COSTELLO, C.; SHANSON, D.C. & GAZZARD, B.G. - Disseminated Mycobacterium avium - intracellulare infection and red cell hypoplasia in patients with acquired immunodeficiency syndrome. J. lnfect. 16:135-140, 1988.
24. GARTNER, S.; MARKOVITS, P.; MARKOVITZ, D.M.; KAPLAN, M.H.; GALLO, R.C. & POPOVIC, M. - The role of mononuclear phagocytes in HTLV III/LAV infection Science. 233:215-218, 1986.
25. GELLER, S.A.; MULLER, R.; GREENBERG, M.L. & SIEGAL, F.P. - Acquired immnodeficiency syndrome. Distinctive features of bone marrow biopsies. Arch. Pathol. Lab. Med.l09:138-141, 1985.
26. GILL, P.S.; RARICK, M.; BRYNES, R.K.; CAUSEY, D.; LOUREIRO, C. & LEVINE, A.M. - Azídothymidine associated with bone marrow failure in the acquired immnunodeficiency syndrome (AIDS). Ann. Intern. Med. 107:502-505, 1987.
27. HAWKINS, C.C.; GOLD, 1.W.M.; WHIMBEY, E.; KIEHN, T.E. BRANNON, P.; CAMMARATA, R.; BROWN, A.E. & ARMSTRONG, D. - Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome. Ann. Intern. Med. 105:184-188, 1986.
28. HEYMAN, M.R. & RASMUSSEN, P. – Pneumocystis carinii involvement of the bone marrow in acquired immunodeficiency syndrome. Am. J. Clin. Pathol. 87(6):780-783, 1987.
29. HIRASUNA, J.D. - Disseminated Mycobacterium kansasii infection in the acquired immunodeficiency syndrome (AIDS) (letter). Ann. Intern. Med. 107 (5):784, 1987.
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Copyright (c) 1994 José Augusto Barreto, Marcos Antonio Gonçalves Munhoz
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