Estudo morfológico de aspirados de medula óssea em pacientes com Síndrome da Imunodeficiência Adquirida
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Palavras-chave

Medula óssea
Mielo-supressores
SIDA

Como Citar

1.
Barreto JA, Munhoz MAG. Estudo morfológico de aspirados de medula óssea em pacientes com Síndrome da Imunodeficiência Adquirida. Rev Inst Adolfo Lutz [Internet]. 30º de junho de 1994 [citado 21º de junho de 2024];54(1):55-63. Disponível em: https://periodicos.saude.sp.gov.br/RIAL/article/view/36533

Resumo

Entre junho e novembro de 1992,estudamos 42 aspirados de medula óssea de pacientes com Síndrome da Imunodeficiência Adquirida (SIDA), grupo IV-C (classificação CDC, 1986), para avaliarmos as alterações morfológicas, qualitativas e quantitativas, decorrentes desta síndrome. Os critérios clínicos para a realização dessas punções foram: febre persistente, anemia, leucopenia, trombocitopenia ou uma combinação dessas anormalidades. Na medula óssea encontramos predomínio de hipocelularidade (71,4%), alterações mielodisplásicas em todos os casos, eosinofilia (19,0%), plasmocitose (45,2%), linfopenia (21,4%) e macrófagos em número aumentado (16,7%). No sangue periférico observamos anemia (81,0%), leucopenia (59,5%), neutropenia (42,9%), linfopenia (88,0%), plaquetopenia (33,3%) e pancitopenia (38,0%). As causas dessas anormalidades são múltiplas: infecções oportunistas, medicamentos mielosupressores, mecanismos imunológicos e ação direta do HIV sobre células progenitoras da medula óssea e células maduras do sangue periférico.

https://doi.org/10.53393/rial.1994.54.36533
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Copyright (c) 1994 José Augusto Barreto, Marcos Antonio Gonçalves Munhoz

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