Keywords
inhalation exposure
toxic effect
How to Cite
Abstract
Household insecticides are used for protecting the urban environment. However, these product might cause health risk. This preliminary study aimed at evaluating the toxic effects of an insecticide for household use (dichlorvos) in rats by inhalation exposure in an unventilated environment. The insecticide was sprayed inside a glass chamber and the rats were exposed for 6 and 24 hours. The plasma cholinesterase activity was analyzed before and after the exposure. The effect of inhalation was reflected on the enzyme depression in association with the exposure length of time. The permanence in the environment without ventilation, for longer time, resulted in higher degreed of intoxication.References
1. Krieger RI, Bernard CE, Dinoff TM, Ross JH, Williams RL. Biomonitoring of persons exposed to insecticides used in residences. Ann Occup Hyg. 2001;45(1001):S143-S153. Disponível em: [http://annhyg.oxfordjournals.org/content/45/suppl_1/S143.full.pdf+html].
2. Butte W. Sources and impacts of pesticides in indoor environments. In: Indoor air pollution. Handbook Environm Chem. 2004;4(F):89-116. Disponível em: [http://faculty.ksu.edu.sa/Almutaz/Documents/Enviro_courses/ENVS-522/Indoor_Air_Pollution.pdf#page=93].
3. Hahn S, Schneider K, Gartiser S, Heger W, Mangelsdorf I. Consumer exposure to biocides - identification of relevant sources and evaluation of possible health effects. Environ Health. 2010;9(7):2-11. Disponível em: [http://www.ehjournal.net/content/9/1/7].
4. Ellman GL, Courtney KD, Andres VJr, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7:88-95.
5. Wilhelm K. Determination of human plasma cholinesterase activity by adapted Ellman method. Arh Hig Rad. 1968;19:199-207.
6. IPCS. International Programme on Chemical Safety. Environmental health criteria for dichlorvos. 1988;79. [acesso 2012 set 17]. Disponível em: [http://www.inchem.org/documents/ehc/ehc/ehc79.htm].
7. Fenske RA, Black G, Elkner KP, Lee C, Methner MM, Soto R. Potential exposure health risks of infants following indoor residential pesticide applications. Am J Public Health. 1990;80(6):689-93. Disponível em: [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1404741/pdf/amjph00219-0041.pdf ].
8. Taylor JT, Davis E, Dabisch P, Horsmon M, Matson K, Crouse C, et al. Acute toxic effects of inhaled dichlorvos vapor on respiratory mechanics and blood cholinesterase activity in guinea pigs. Inhal Toxicol. 2008;20(5):465-72. Disponível em: [http://link.periodicos.capes.gov.br/sfxlcl41?url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&ctx_enc=info:ofi/enc:UTF-8&ctx_ver=Z39.88-2004&rfr_id=info:sid/sfxit.com:azlist&sfx.ignore_date_threshold=1&rft.object_id=954925271384&svc.fulltext=yes].
9. Maroni M, Colosio C, Feriolo A, Fait A. Biological monitoring of pesticide exposure: a review. Introduction. Toxicology. 2000;143(1):9-37. Disponível em: [http://ac.els-cdn.com/S0300483X99001523/1-s2.0-S0300483X99001523main.pdf ?_tid=149a2810-f694-11e1-bad3-00000aab0f02&acdnat=1346765345_b2448bb470025860f9bfbf5459ef9da3].
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