Abstract
The authors study the effects of adrenal cortical hormones on the blood picture and on the production of antibodies, in the rabbit. The sub-cutaneous injection of 10 ml of aqueous adrenal cortical extracts produces an increase in the number of neutrophils (pseudo-eosinophils), and a decrease in the number of lymphocytes of the peripheral blood. There was no apparent effect on the production of antibodies, as revealed by the failure of the cortical hormones to increase the titer of aglutinative sera of rabbits previously immunized with bacterial antigens.
References
1. DOUGHERTY,T. F. e WHITE, A. - 1943 - Effect of pituitary adrenotrophic hormone on lymphoid tissue. Proc, Soc. Exper. Biol. & Med. 53: 132-133
2. DOUGHERTY,T. F. e WHITE, A. _ 1943 - Influence of adrenal cortical secretion on blood elements. Science 98: 367-369.
3. DOUGHERTY,T. F. e WHITE, A. 1944 - Influence of horrnones on lymphoid tissue structure and f'unct.ion. The role of the pituitary adrenotrophic hormone in the regulation of the lymphocytes and other cehular elements of the blood. Endocrinology 53: 1-14.
4. RElIHARDT,W. O., ARON, H., e LI, C.H. - 1944 - Effect of adrenocorticotrophic hormone on leukocyte picture of normal rats and dogs. Proc. Soc. Exper. Biol. & Med. 57: 19-21.
5. DOUGHERTY,T. F., e WHITE, A. - 1947 - An evaluation of alterations produced in Iymphoid tissue by pituitary-adrenal cortical secretion J. Lab. & Clin. Med. 32:584-605.
6. VALENTINEl,W. N., CRADDOCK,C. G.e LAWRENCE,S. J. - 1948 - Relation of adrenal cor ti cal horrnone to lymphoíd tissue and lymphocytes, Blood, 3 :729-754.
7. GORMANHILLS, A., FORSRAM, P. H. FINCR, C. A. ~ 1948- Changes in circtnating leukocytes llllduced by the administration of pituítary adrenocorticotrophic horrnone (ACTH) in mano Blood, 3:755-768.
8. WH'ITE, A. e DOUGRERTY,T. F. - 1944 - Influence of pituitary adrenotrophic hormone on lymphoid tissue structure in relation to serum proteins. Proc. Soc. Exper. Biol. & Med. 56 :26-27.
9. DOUGHERTY,T. F., e WHITE, A. - 1945 - Functional alterations in lymphoid tissue induced by adrenal cortical secretion. Am. J. Anat. 77 :81-116.
10. HARRIS, T. N., GRIN, E., MERTENS, E., e EHRICR, W. E. - 1945 - The role of the lyrnphocyte in antibody formation. J. Exper. Med, 81 :73-83.
11. DOUGHERTY,T. F., WHlTE, A., e CRASE, J. H. - 1944 - Relationship of the effects of adrenal cortical secretíon on iymphoid tissue and on antibody títer. Proc. Soc. Exper. Biol. & Med, 56:28-29.
12. DOUGHERTY,T. F., CRASE, J. H. e WHITE, A. - 1945 - Pituitaryadrenal cortical control of antibody release fromlymphocytes. An explanation of the anamnestic response, Proc. Soc. Exper. Biol. & Med. 58: 135-140.
13. CHASE, J. H., WHITE, A. e' DOUGHERTY,T. F. - 1946 - The enhancernent of circulating antibody concentration by adrenal corticaí horrnones, J. lmmunol. 52:101-112.
14. CHENG, S. C. - 1930 - Leucocyte counts in rabbits: observations on the influence of various phisiological factors and pathologie conditions. Am. J. Hyg. 11 :449-533.
15. THORN, G. W., FORSHAM, P. H., GARNE.TPRUNTY, F. T., e GORMAN HILLS, A. - 1948 - A test for adrenal cortical Insuff'iciency. The response to pituitary adrenocortícotrophíc hormone. J. A. M. A. 137 :1005-1009.
16. LI, C. H. e REINHARDT,W. O. - 1947 _ Eiectrophoresis of rat plasma. 11. The eff'ect of adrenocorticotrophic hormone. J. Biol. Chem. 167:487-493.
17. EISEN, H. N., MAYER,M. M., MOORE,D. H., TARR, R. e STOERK,H. C. - 1947 - Failure of adrenal cortical activity to influence circulating antibodies and gamma globulin. Proc. Soc. Exper. Biol. & Med. 65 :301-306.
18. HARRIS, S., e HENLE, W. - 1948 - Lymphocitopenia In rabbíts following intravenous injection of influenzal vírus. J. lmmunol. 59 :9-20.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 1948 Instituto Adolfo Lutz Journal