Determinação de pantotenato de cálcio em medicamentos

Waldomiro Pregnolatto; Ione Irulegui

doi:10.53393/rial.1965.25.33434

, ORIGINAL ARTICLE

Determination of pantothenate in pharmaceutical preparations

ORIGINAL ARTICLE

https://doi.org/10.53393/rial.1965.25.33434

Published 1965-01-31

Waldomiro Pregnolatto⁺⁻
Ione Irulegui⁺⁻

Waldomiro Pregnolatto

Do Instituto Adolfo Lutz.

Ione Irulegui

Do Instituto Adolfo Lutz.

PDF (Português (Brasil))

How to Cite

1.

Pregnolatto W, Irulegui I. Determination of pantothenate in pharmaceutical preparations. Rev Inst Adolfo Lutz [Internet]. 1965 Jan. 31 [cited 2024 Jul. 3];25:115-8. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/33434

Abstract

A simple method for the determination of calcium or sodium pantothenate and pantothenic acid in pharmaceutical preparations is presented. The property of the mentioned compounds of forming beta-alanine by a acid hydrolysis is used. The beta-alanine formed is purified by paper chromatography and detected with ninhydrin. The stain is eluted and the absorbance measured according to Giri, Radhakrishnam & Vaidyanathan. Hydrolysis conditions were studied as well as the possible interference of other amino-acid which may be present. Several kinds of solvent for development of the chromatogram were also studied.

https://doi.org/10.53393/rial.1965.25.33434

PDF (Português (Brasil))

References

1. SCHMALL, M. & WOLLISH, E. G. - Determination of panthenol and pantothenates in multivitamin preparations. Ana.L Chem. 29:1509-513, 1957.

2. YAMAGISHI, M. & YOSHIDA, T. - Ninhydrin reaction. IV. Determlna tíon of pantothenic acid. J. Pharm. Soe. Japan 74:1001-4, 1954. Resumo in Chem. Abstr. 49:1488a, 1955.

3. RODRIGUES, L. D. & SILVA, J. A. - Separation and identification in pharmaceutical products of the principal vitamins of the B complex with chromatographic paper. Rev. Porto Farm. 5:75-88, 1955. Resumo in Chem. Abstr. 50: 1264d, 1956.

4. SICHO, V. & KAKAO, B. - Estimation or pantothenic acid by means of paper chromatography. Casopis Lékaru Ceskych. 92:1372-3, 1953. Resumo in: Chem. Abstr. 51:18084i, 1957.

5. HUBBARD, W. D. et alii - Chemícal Determination of calcium pantothenate, J. Ass. Off. Agric. Chem. 48:1217-20, 1965.

6. ZAPPALA, A. F. & SIMPSON, C. A. - Sensitive colorimetric method for the determination of panthenol in multtvitamin preparation. J. Pharm. Sci. 50:845, 1961.

7. GIRI,:K. V.; RADHAKRISHNAN, A. N. & VAIDYANATHAN, C. S. - Some factors influencing the quantitive determination of amíno acids separed b:y circular paper chromatography, Anal. Chem. 24:1677-678, 1952.

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