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The purpose of this study was to evaluate the susceptibility of Mycobacterium tuberculosis to drugs. During the period of April/1998 to March/1999, clinical specimens from 235 respiratory syptomatic patients or pulmonary tuberculosis diagnosed who were attended at the Basic Health Units of São Vicente municipality were submitted to smear microscopy, culture, identification and susceptibility test. We found 101 (45,70%) positive samples in the culture exams. Among these, 87 (86,14%) belonged to the MTb complex with 11 (12,6%) showing a “suggestive” acquired resistance due to a previous treatment abandon. According to this analysis, the authors suggest, in the mentioned municipality, changes related to the criteria for tuberculosis diagnostic examination request, such as the introduction of culture and susceptibility test to every tuberculosis suspected patients or pulmonary tuberculosis diagnosed. This continuous monitoring procedure might allow actions of vigilance control of treatment abandon cases, drug resistance and the spread of multiresistant tuberculosis, contributing to a betterment of treatment effectiveness and improvement in the diagnosis quality.
References
2. Brasil, Ministério da Saúde/FUNASA/PNCT. Documento básico da reunião de Avaliação Operacional e Epidemiológica do PNCT na década de 80. Bol. Pneumol. Sanit., n. Especial: 9-87, 1992.
3. Brasil, Ministério da Saúde/FUNASA/PNCT. Manual de Normas para o Controle da Tuberculose, 4a. ed..Brasília, 1995.
4. Collins, C.H.; Grange, J.M.; Yates, M.D. Tuberculosis Bacteriology – Organization and Pratice, 2nd ed.. Oxford Butterworth – Heinemann, 1997.
5. Fiuza de Melo, F.M.; Afiune, J.B. Drogas antituberculosas no Brasil: multiresistência. Avs Curandi, 25:51-58, 1992.
6. Fiuza de Melo, F.M.; Afiune, J.B. Quimioterapia da tuberculose: bases, condutas e procedimentos. J.Pneumologia, 19:42-49, 1993.
7. Fiuza de Melo, F.M. et al., Resistência Primária do “Mycobacterium tuberculosis” num serviço ambulatorial de referência em São Paulo: evolução por três décadas e comparação com outros estudos nacionais. J. Pneumologia 22(1), 1996.
8. Fiuza de Melo, F.M. Tuberculose: um assunto atual e oportuno. J. Pneumologia, 19:III,1993.
9. Fiuza de Melo, F.M.; Ide Neto, J.; Seiscento, M. et al. Tuberculose multirresistente. J. Pneumol. 19:73-82, 1993.
10. Fiuza de Melo, F.M.; Ide Neto, J.; Seiscento, M. et al. Tuberculose multirresistente no Brasil, uma definição operacional ou bacteriológica? J. Pneumol. 22, 1996.
11. Fox, W.; Witchison, D.A. Quimioterapia de la tuberculosis.OPAS/ OMS, Publ.Cient. 310,1975.
12. Iseman, M.D. Treatment of multidrug-resistant tuberculosis. N. Engl. J. Med.,784-91, 1993.
13. Jarad, N.A.; Parastatides, S.; Paul, E.A.; Sheldon, D.C.;Gaya, H.; Rudd, R.M.; et al.. Characteristics of patients with drug resistant and drug sensitive tuberculosis in east London between 1984 and 1992. Thorax, 49: 808-810, 1994.
14. Kantor, I.N.; Latini, O.; Barrera, L. La Resistencia y Multirresistencia a los Medicamentos Antituberculosos en la Argentina y en Otros Paises de America Latina. Medicina (Buenos Aires), 58:202-208, 1998.
15. Kent, P.T.; Kubica, G.P. Identification test techiniques.In: Public Health Mycobacteriology. A guide for the Level III Laboratory. Centers for Disease Control, Atlanta, p. 207, 1985.
16. Larrosa, J.R.; Corradi, H.; Braselli, A. Primeros casos de tuberculosis multirresistentes en SIDA. Uruguay. Arch. Med., XIX; 2:67-70, 1997.
17. Levy, U. et al. A reevaluation of sputum microscopy and culture in the diagnoses of pulmonary tuberculosis. Chest. 95:11931197, 1989.
18. Ministério da Saúde, Coordenação Nacional de Pneumologia Sanitária e Sociedade Brasileira de Pneumologia e Tisiologia. I Consenso Brasileiro de Tuberculose. J. Pneumologia, 23(6), 1997.
19. Ministério da Saúde, Programa Nacional de Combate da Tuberculose. Manual de Bacteriologia da Tuberculose, 1ª ed. Rio de janeiro. Fundação Nacional da Saúde, 1998.
20. Mitchison, D.A. Bacteriology of tuberculosis. Trop. Doct., 4:1413, 1974.
21. Mitchison, D.A. The action of antituberculosis drugs in shortcourse chemoterapy. Tubercle, 66:219-225, 1985.
22. Neville, K.; Bromberg, A.; Bromberg, R.; Bonk, S.; Hanna, B.A.; Rom, W.N. The third epidemic-multidrug-resistant tuberculosis. Chest.,105:45-48, 1994.
23. Petroff, S.A. A new rapid method for the isolation and cultivation of tubercle bacilli directly from sputum and feces. J. Exp. Med., 21:38, 1915.
24. Rosemberg, J. Quimioterapia da tuberculose: I – Princípios fundamentais. II – Medicamentos. Tipos de tratamento. Avaliação e controle. Rev. Ass. Med. Brasil, 29:90-101, 1983.
25. Silva, E.A.M.; Sato, D.N.; Telles, M.A.S.; Martins, M.C.; Palaci, M.; Ueki, S.Y.M. Perfil de resistência de Mycobacterium tuberculosis no Estado de São Paulo, 1986 a 1990. Rev. Inst. Adolfo Lutz, 52(1/2):37-40, 1992.
26. Toman, K. Tuberculosis case-finding and chemoterapy. Questions and Answers. WHO, 1979.
27. Vareldezis, B.P.; Grosset, J.; Kantor, I.; Crofton,J.; Laszlo, A.; Felten, M.; Raviglione, M.C.; Kochi, A. Drug-resistant tuberculosis: laboratory issues. Tubercle Lung Dis,75:1-7, 1994.
28. WHO Global Tuberculosis Programme. Anti-tuberculosis drug resistance in the world. The WHO/IUATLD Global Project on Anti-tuberculosis Drug resistance Surveillance 1994-1997. WHO/TB/97.229. WHO, Geneva, 1997.
29. WHO. Treatment of tuberculosis: guidelines for national programmes. WHO/TB/97.220. Seconde Edition, WHO, Geneva, 1997.
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Copyright (c) 2001 Priscila C.R. Jardim, Liliana A. Zamarioli, Andréa G.V. Coelho, Teresa R. Figueiredo, Mauro A. Rozman