Abstract
In order to determinate the situation of antituberculosis drug resistance in the State of São Paulo, 1668 strains of Mycobacterium tuberculosis have been studied; 254 of them were obtained from sputum of patients without previous medical treatrnent and 1414 of patients during the treatment. The initial resistence rated 16.54% and the acquired resistence rated 47.45%. The Mycobacterium tuberculosis showed a isoniazid global resistence of 10.62% and rifampicin global resistence of 6.69% showing that the most important drugs used in the tuberculosis treatrnent are presenting high resistance rate. This fact is worrisome, since it can cause the treatment failure and consequently, cause difficulties to the disease control.
References
2. BARRETO, A. M. W. & MARTINS, F. M. – Estudo da resistência primária no Brasil no período de1986 a 1988. Bol. Campanha Nac. Contra a Tuberc., 2: 21 - 25,1988.
3. BEZEM, L. S.; VIEIRA, L. M. T.; ABRAHÃO, J. S.; GOMES, C. & ANDRADE, A. J. S. - Resistência primária aos tuberculostáticos no Estado de Santa Catarina. Bol. Campanha Nac. Contra a Tuberc., 2: 34 - 44, 1988.
4. CANETTI, G.; RIST, N. & GROSSET, J. – Mesure de la sensibilité du bacille tuberculeux aux drogues antibacillaires par la méthode des proportions: méthodologie, critêres de résistence, résultats, interpretations. Rev. Tuberc. (Paris) 27: 217 - 272,1963.
5. CANETTI, G.; FOX, w.; KHOMENKO, S.; MAHLER, H. T.; MENON, N. K.; MITCHISON, D. A.; RIST, N. & SMELEV, N. A. – Advances in techniques of testing mycrobacterial drug sensitivity test in tuberculosis programmes. Bull. Wld. Hlth. Org., 41: 21 - 43, 1969.
6. EIDUS, L. - A national study to determinate the prevalence of drug resistence in newly discovered previously patients as well as in retreatment. Canad. J. pub. Hlt., 69: 146 - 153, 1978.
7. DAVID, H. L. - Probability distribution of drug-resistant mutants in unselected populations of Mycobacterium tuberculosis. Appl. Microbiol., 20: 810 - 814, 1970.
8. KANTOR, I. N. - Bacetriologia de la tuberculosis humana y animal. Martinez, Centro Panamericano de Zoonosis, 1988. (Serie de Monografias Científicas y técnicas. 11/Rev.I).
9. KANTOR, I. N. - Information sobre resultados de la encuesta regional (OPS - OMS) sobre resistencia a drogas antituberculosas. Bol. Inform. Colabat., 5: 8 - 9, 1989.
10. MINISTÉRIO DA SAÚDE - Controle da Tuberculose: uma proposta de integração ensino serviço. Brasil. Rio de Janeiro, 1992.
11. MINISTÉRIO DA SAÚDE - Manual de normas para o controle da tuberculose. Brasília, 1988.
12. SALEM, J. I.; GOH, K. S.; LITAIFF, L. R. L.; CARCLOSO. M. S. L. & BRIGLIA, M. F. S. - An investigation of primary and acquired drug resistence of Mycobacterium tuberculosis in Manaus (Amazonas, Brazil). J. Pneumol. 16 : 6 - 8, 1990.
13. TOMAN, K. - Tuberculosis, detection de casos y quimioterapia. Preguntas y respuestas. Washington D. C. Organizacion Panamericana de la Salud. 1980. (Publi. Cient. 392).
14. VALENZUELA, P. & VALENZUELA, M. T. - Utilidad clinica y epidemiológica de los estudios de sensibilidad a drogas antituberculosas. Acta.méd. FAB, 54 - 64, 1985.
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