Keywords
Drug susceptibility tests
Drug resistence
How to Cite
Abstract
The treatment of M. kansasii infection have been conduced as a tuberculosis. Since rifampin was introduced in the drug regimens for disease due to M. kansasii the sputum conversion from positive to negative is confirmed in 100%. This study was made to contribute in the treatment of disease due to M. kansasli. Through of Minimal Inhibitory Concentration and Minimal Bactericidal Concentration determination and susceptibility tests by proportion method, the authors compared the results that was obtained with the results of international data. 30 M. kansasii strains isolated of patients with pulmonary disease were studied. A susceptibility testing using the conventional antituberculosis drugs isoniazid, rifampin, streptomycin, ethambutol, ethionamide, kanamycin and ciprofloxacin was made according to the standardized techniques. The results showed that M. kansasii was sensible to rifampin, ethionamide, kanamycin and ciprofloxacin, while to another drugs the results were varied. Our data showed that rifampin is essential in the drug regimen of M. kansasii infection and the usefullness of susceptility tests in the retreatment.
References
2. AHN, C.H.; LOWELL, J.R.; AHN, S.S; AHN, S. and HURST, G.A. Short-course chemotherapy for pulmonary disease caused by Mycobacterium kansasii. 1983. Am. Rev. Resp. Dis. 128:1048-50.
3. AHN, C.H.; WALLACE Jr, RJ.; STEELE, L.C. and MURPHY, D. T. Sulfonamide containing regimens for disease caused by rifampin-resistant Mycobacterium kansasii. 1987. Am. Rev. Resp. Dis.135:10-16.
4. BECK, A and STANFORD, J.L. Mycobacterium xenopi: a study of sixteen strains. 1968. Tubercle. 49:226-34.
5. CANETTI, G.; FOX, W.; KHOMENKO, A; MAHLER, H.T.; MENON, N.K.; MITCHISON, D.A; RlST, N. et SMELEV, N.A Advances in techniques of testing mycobacterial drug sensitivity tests in tuberculosis programmes. 1969. Bull. WHO 41:21-43.
6. COLLINS, C.H. and UTTLEY, H.C. In vitro susceptibility of mycobacteria to ciprofloxacin. 1985. J. Antim. Chemoth. 16:575-80.
7. DAVID, H.L. Basis for lack of drug susceptibility of atypical mycobacteria. 1981. Rev. Inf. Dis. 3(5):878-84.
8. DAVID, H.L.; LEVY-FREBAULT, V. et PAPA, F. Méthodes de Laboratoire Pour Mycobacteriologie Clinique (Supplement à "Mycobacteriologie Clinique et de Santé Publique" - Manuel de la S.E.M.). 1986. Unité de la Tuberculose et des Mycobactéries. Institut Pasteur. Paris.
9. GANGADHARAM, P.R. and GONZALES, E.R. Influence of medium on the "in vitro" susceptibility of Mycobacterlum tuberculosis to ethambutol. 1970. Am. Rev. Resp. Dis. 102:653-55.
10. GAY, J.D.; YOUNG, D.R. and ROBERTS, G.D. In vitro activities of norfloxacin and ciprofloxacin against Mycobacterium tuberculosis, Mycobacterium avium complex, Mycobacterium chelonei, Mycobacterium fortuitum and Mycobacterium kansasii. 1984. Antim. Ag. Chemoth. 26(1):94-96.
11. HAWKINS, J.E.; WAUACE Jr, R. J. and BROWN, B.A Antibacterial susceptibility test: Mycobacteria. In: Manual of Clinical Microbiology. 1991. Albert Balows (ed.) 5th Ed. Washington D. C. p. 1138-1152.
12. HEIFETS, L. Qualitative and quantitative drug-susceptibility test in Mycobacteriology. 1988. Am. Rev. Resp. Dis. 137:1217-22.
13. KANTOR, I.N. Bacteriologia de la tuberculosis humana y animal. 1988. Centro Panamericano de Zoonosis. OPS/OMS. Monografia n. 11/rev. 1.
14. KUBIN, M.; SVANDOVA, E.; MEDEK, B.; CHOBOT, S. and OLSOVSKY, Z. Mycobacterium kansasii infection in an endemic area of Czechoslovakia. 1980. Tubercle. 61:207-12.
15. MANIAR, C.A. and VANBUCKENHOUT, L.R. Mycobacterium kansasii from an environmental source. 1976. Can. J. of Public Health. 67:59-60.
16. NAKAMURA SATO, D.; SILVA, E.A.M.; PALACI, M.; UEKI, S.Y.M.; TELLES, M.A.S.; MARTINS, M.C. and LEITE, O.H.M. Susceptibilidade "in vitro" de cepas de Mycobacterium tuberculosis à ciprofloxacin. 1990. Rev. Lat.-amer. Microbiol. 32:249-53.
17. PEZZIA, W.; RALEICH, J.W.; BAILEY, M.C.; TOTH, E.A and SILVERBLATI, J. Treatment of pulmonary disease due to Microbacterium kansasii: recent experience with rifampin. 1981. Rev. Inf. Dis. 3(5): 1035-39.
18. SILVA, E.AM.; MIRANDA, J.B.N.; FERRAZOU, L.; ALGE, M.E.; SILVA, R.R.F.; FUZlHARA, T.O. and PALACI, M. Ocorrência de infecções pulmonares devidas ao Micobacterium kansasii, em São Paulo, Brasil. 1987. Rev. Inst.Adolfo Lutz. 47(1/2):11-17.
19. The Mycobacterioses Research Group of 'Japanese National Chest Hospitais. Rapid increase of the incidence of lung disease due to Mycobacterium kansasii in Japan. 1983. Chest. 83(6):890-92.
20. THRUPP, M.D. Susceptibility testing of antibiotics in liquid media. In: Antibiotics in Laboratory Medicine. 1986. Victor Lorian (ed.) 2nd Ed. Baltimore M.D. Williams & Wilkins. p. 93-150.
21. TSANG, A.Y.; BENTZ, R.R.; SCHORK, A and SODEMAM, T.M. Combined vs. single-drug studies of streptomycin and ethambutol. 1976. Am. J. Clin. Pathol. 70:816-20.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 1993 Instituto Adolfo Lutz Journal