Keywords
meningitis
virulence factors
How to Cite
Abstract
Among virulence factors in bacteria investigated in the Seção de Bacteriologia of the Instituto Adolfo Lutz, the occurrence of immunoglobulin A proteases (IgA1 proteases) has been evaluated. These extracellular enzymes are produced by different mucosal pathogens, including the three major agents of bacterial meningitis: Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae. IgA1 proteases were detected by immunoelectrophoresis in 28 of 39 strains studied, bacteria and yeasts. Except for 7 bacteria from collection, ali organisms were isolated from cerebrospinal f1uid. ln the three most frequent etiological agents of meningitis, IgA1 proteases were observed, as well as in four other bacteria, two of which from collection, and not cited in the literature as enzyme producers.
References
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