Keywords
hepatitis, A, B
B lymphocytes in hepatitis, frequency
T lymphocytes in hepatitis, frequency
How to Cite
Abstract
The number of T Iymphocytes, B Iymphocytes and T Iymphocytes forming E rosette stable at 37°C was determined in a g roup of 140 patierrts with
clinical and laboratory diagnosis of acute hepatitis attended in a hospital for infectious diseases of. the City of São Paulo between October 1981 and IvIay 1982. Serological tests for antigens andjor antibodies for hepatitis A and B viruses disclosed that 37.80/0of the patients had A hepatitis and 50.70/0had B hepatitis, while 11.50/0were nega tive for hepatitis A or B and were thus considered as undetermined hepatitis. The number of Iymphocytes was determined on the day of clinical diagnosis and later at 60 and 360 days. The number of T lymphocytes was increased in most patients with hepatitis A or B but returned to normal levels 60 or 360 days in the patients with undetermined hepatitis. B lymphocytes were normal in the majority of patients, irrespective of time or hepatitis type. No significant alteration of T lymphocytes forming E rosette stable at 37°C was observed in most patients during the whole period of study. Some interpretations are ma de of the relationships between lymphocyte levels and the type and form of acute hepatitis.
References
ating T and B lyrnphocytes and immunoglobulin containing cells in the liver in
chronic active liver disease. Acta path. microbiol. Scand. (Sect. C), 85 :26-32, 1977.
2. BbYUM, A. - Separation of leukocytes from blood and bone marrow. Scand. J. clin. Lab. Invest., 21 (suppl. 97): 1-109, 1968.
3. CAMPBELL, A. R.; WALLER, C.; WOOD, J.; AYNSLEY-GREEN, A. & YU, V. -- Lym-
phocyte subpopulations in the blood of newborn infants. Clin. exp. Immumol., 18: 469-82, 1974.
4. CHISARI, F. V.; ROUTENBERG, J. A.; ANDERSON, D. S. & EDGINGTON, r. S.
-- Cellular immune reactivity in HBV induced liver disease, In: VYAS, G. N., COHEN, S. N. & SCHl\1IDT, R., ed. - Viral hepatitis. Philadelphía, Franklin Institut press, 1978. p. 245-57.
5. COLOMBO, M.; VERNACE, S. J. & PARONETTO, F. - T and B lymphocytes in
patients with chronic active hepatitis (CAH). Clin. exp. Immunol., 30:4-9, 1977.
6. D'AMELIO, R.; CIARLA, M. V.; PANDOLFI, F.; PANlCHI, G.; SPOSITO, M. & AIUTI, F. - T and B lymphocytes in the liver and peripheral blood of subjects with acute and chronic hepatitis. Z. Immunitaets-forsch., 155:338-45, 1979.
7. DE HORATIUS, R. J.; STRICHLAND, R. G. & WILLIAMS, R. C., JR. - T and B lymphocytes in acute and chronic hepatitis. Clin. Immunol. Immunopathol., 2 :353-60, 1974.
8. DUDLEY, F. J.; GIUSTINO, V. & SHERLOCK, S. - Cell-mediated immunity in
patients positive for hepatitis-associated antigen. Br. meti, J., 4:754-6, 1972.
9. GALILI, U.; ELIAKIM, M.; SLAVIN, S. & SCHLESINGER, M. - Lyrnphoeyte sub-
populations in chronic active hepatitis: Increase in lymphocytes forming stable E-rosettes. Clin. lmmunol. lmmunopathol., 4:538-44, 1975.
10. GALILI, U. & SCHLESINGER, M. - Sub-populations of human thymus cells differing in their capacity to form stable E-rosettes and their ímmunologic reactivity. J. lmmunol., 115:827-33, 1975.
11. GALILI, U. & SCHLESINGER, M. - The formation of stable E-rosettes by human T lymphocytes activated in mixed lymphocyte reactions. J. lmmunol., 117: 730-5, 1976.
12. THOMAS, H. C.; FRENI, M.; SANCHEZ-TAPIAS, J.; DE VILLIERS, D.; JAIN,
S. & SHERLOCK, S. - Peripheral blood lymphocy te populations in chroriic liver di-
sease. Clin. exp. Immunol., 26 :222-27, 1976.
13. WANSBROUGH-JONES, M. H.; SCULLARD, G. H.; NICHOLSON, A.; EDDLESTON, A. L. W. F. & WILLIANS, R. - Lympho-cytes forming stable E-rosettes in acute and chronic hepatitis. Clin. exp. lmmunol., 35 :390-6, 1979.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 1984 Instituto Adolfo Lutz Journal