Abstract
The response to the antigenic stimulus of meníngococcic polysaccharide vaccine was evaIuated through passive haemaggIutination in individuaIs in the age group of O to older than 21 years old, Vaccine A was found to be more immunogenic than vaccine C. No cross reactíons were found between A and C polysaccharídes, The reaction proved to be specífíc for both groups of meningococcus, thus allowing correct diagnosis of meningococcíc dísease in many ínstances where other diagnostic test have faíled. The passíve haemagglutination was inefective as a díagnostícal test in patíents who had been vaccinated with AC antimeníngococcíc vaccine, because most of these patíents presented low haemagglutinating títles without serologícal conversion and, when it was present, It was not possible to know weather it was due do the vaccine or to the descase.
References
2. COHEN, R.L. & ARTENSTEIN, M.S. Hemagglutination inhibition for seregrouping of Neisseria meningitidis. Appl. Microbiol., 23: 289-92, 1972.
3. EDWARDS, E.A. & DRISCOLL, W.S. Group-specific hemagglutination test for Neisseria meningitidis antibodies. Proc , Soc. exp. Biol. teea., 126: 876-9, 1967.
4., EICKHOFF, T. C. Sero-epidemiologic studies of meningococcal infection with the indirect hemagglutination test. J. infect, Dis., 123 (5): 519-26, 1971.
5. HAMMOND, B.W.; KINGSBURY, D.T. & WEISS, E. - Modification of meníngocoe cal polysaccharide antigens for use in passive hemagglutination tests. J. Immun., 101: 808-9, 1968.
6. HUNTLEY, B. & REED, D. - A'n indirect hemagglutination test for group B meningococcus. Am. J. Epidem. 86: 142-8, 1967.
7. JONES, D.M. & TOBION, D.M. - Incidence of hemagglutination antibodies to meningococci in North-West England. J. clin. Path., 25: 955-8, 1972.
8. ROSSI, V.C.; DINIZ, J.M.P.; ADELINO, M.G.F.; TAKEDA, A.K.; TAUNAY, A. E. & CANDIO, S. - Resposta humoral aos polissacarídeos obtidos da N. meningitidis dos grupos A e C utilizados na vacinação e revacinação antimeningocócíca. Rev. Inst. Adolfo Lutz, 37, 1977. [No prelo]
9. SANBORN, W. R. & VEDROS, N. A. - Possibilities of aplication of complement fluorescent antibody test to epidemíology
fixation, indirect hemagglutination and of meningococcal infection. Hlth. Lab. Sei., 3: 311-7, 1966.
10. TAKEDA, A.K. TAUNAY, A. E. SCALABRINI, L.G.P. & CASTRO, I.0. - Anticorpos antipolissacarídeo C de Neisserie meningitidis: detecção através da hemaglutinação passiva em soros de pacientes e de vacinados. Rev. Inst. Adolfo Lutz, 34: 127-33, 1974.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 1976 Instituto Adolfo Lutz Journal