Pharmacodynamic study of aromatic and heterocyclic diethylamides
Vol. 37 No. 1-2 (1977), ORIGINAL ARTICLE
Vol. 37 No. 1-2 (1977)

Pharmacodynamic study of aromatic and heterocyclic diethylamides

ORIGINAL ARTICLE
https://doi.org/10.53393/rial.1977.37.37104
Published 1977-12-30
Héctor T. Araldi
From the Instituto Nacional de Farmacologia y Bromatologia
Consuelo E. Agrelo
From the Instituto Nacional de Farmacologia y Bromatologia
Marcelo J. Vernengo
From the Instituto Nacional de Farmacologia y Bromatologia
pdf (Português (Brasil))

Keywords

diethylamides, aromatic and heterocyclic
diethylamides, pharmacodynamics

How to Cite

1.
Araldi HT, Agrelo CE, Vernengo MJ. Pharmacodynamic study of aromatic and heterocyclic diethylamides. Rev Inst Adolfo Lutz [Internet]. 1977 Dec. 30 [cited 2024 Dec. 26];37(1-2):75-84. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/37104
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Abstract

The analeptic effect of Anacardiol compared with that of Nikethamide and Pentylenetetrazol has been studied in rats, cats, dogs, and rabbits. Anacardiol had an irregular effect, inducing in some cases abnormal respiratory patterns, including apnea. Pentylenetetrazol had a clear cut effect, and Nikethamide was mildly effective. However, its depressor component limits its use. Comparing the reported LD50 in rats and our experimental effective doses for NThe analeptic effect of Anacardiol compared with that of Nikethamide
and Pentylenetetrazol has been studied in rats, cats, dogs, and rabbits.
Anacardiol had an irregular effect, inducing in some cases abnormal respiratory
patterns, including apnea. Pentylenetetrazol had a clear cut effect, and Nikethamide
was mildly effective. However, its depressor component limits its use. Comparing
the reported LD50 in rats and our experimental effective doses for Nikethamide,
Pentylenetetrazol, and Anacardiol, the last one would possess the smallest
safetyratio. ikethamide, Pentylenetetrazol, and Anacardiol, the last one would possess the smallest
safetyratio.

https://doi.org/10.53393/rial.1977.37.37104
pdf (Português (Brasil))

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Copyright (c) 1977 Instituto Adolfo Lutz Journal

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