Keywords
Neisseria meniouritidis, serogroup C
meningitis, meningococcic
How to Cite
Abstract
A description is ma de of the methodology employed to assess the protection conferred by the Merck, Sharp & Dohme anti-meningococcic vaccine
which was used a mass vaccination compaign conducted in the City of São Paulo, Brazil, during an epidemic. The etiologic agent of this epidemic was identified
as type C Neisseria meningitidis. For the assessment, 6 to 36 month-old children were chosen among those vaccinated from December 12 to 22, 1972. The sample included 67,299 children who received the vaccine and 67.299 who received a placebo (diph theric- tetanic toxoide). Surveillance of the total 134,549 children was ma de until June 3, 1974, when it was interrupted because of the occurrence of a new
epidemic during which patients were admitted to various hospitais rather than to a single one, as in the study epidemic. It was concluded that those children who were 24 to 36 month-old at the time of vaccination showed a lower attack rate when the agent was type C N. meningitidis.
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Copyright (c) 1978 Instituto Adolfo Lutz Journal