Palavras-chave
Violaceína
tuberculose
antimicobacteriano
Chromobacterium violaceum
Mycobacterium tuberculosis
in vitro
tuberculose
antimicobacteriano
Chromobacterium violaceum
Mycobacterium tuberculosis
in vitro
Como Citar
1.
Olivia de Souza A, Cristina Girello Aily D, Nakamura Sato D, Durán N. Atividade da violaceína in vitro sobre o Mycobacterium tuberculosis H37Ra. Rev Inst Adolfo Lutz [Internet]. 30º de junho de 1999 [citado 5º de maio de 2024];58(1):59-62. Disponível em: https://periodicos.saude.sp.gov.br/RIAL/article/view/36676
Resumo
Este estudo relata a atividade antimicobacteriana da violaceína,3-[1,2Dihidro-5 - (5-hidroxi-1H-indol-3-il)-2-oxo-3H-pirrol-3 ilideno] 1,3-dihidro-2H-indol-2-ona sobre a cepa padrão de M. tuberculosis H37Ra. A violaceína apresentou ação antimicobacteriana in vitro com concentração inibitória mínima (CIM) de 64 ug/ml. e concentração bactericida mínima (CBM) de 128 ug/rnl., Estes valores são comparáveis aos descritos na literatura para a pirazinamida.
Referências
1. BARBACHYN, M.R.; HUTCHINSON, D. K.; BRICKNER, S.J.; CYNAMON, M.H.; KILBURN, J.O.; KLEMENS, S.P.; GLICKMAN, S.E.; GREGA, K.C.; HENDGES, S.K.;
TOOPS, D.S.; FORD, C.W. & ZURENKO, G.E. Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity. J. Med. Chem., 39: 680-685, 1996.
2. CAMPOS, Y.; ERAZO, S. & DURÁN, N. Novos Fotoprodutos com Atividade Antimicrobiana de Chromobacterium violaceum. Arq. Biol. Tecnol., 25:147, 1982.
3. CENTERS FOR DISEASE CONTROL AND PREVENTION. Estimates of future global tuberculosis morbity and mortality. Morb. Mort. Weekly Rep., 39:1542-1545, 1995.
4. COHN, D.L.; BUSTREO, F. & RAVIGLIONE, M.C. Drug resistant tuberculosis: review of the world wide situation and the WHO/IUATLD Global Surveillance Project. Clin. Infect. Dis., 24:S121-S130, 1997.
5. CYNAMON, M.H.; SPEIRS, RJ. & WELCH, J.T. In vitro antimycobacteria1 activity of 5Chloropyrazinamide. Antimicrob. Agents Chemother., 42:462-463, 1998.
6. DEMOSS, RD. Violacein. Antibiotics. 2: 77-81, 1967.
7. DURÁN, N & HAUN, M. Processo de produção, obtenção, purificação e atividade antitumoral de 3-[1,2-Dihidro-5-(5-hidroxi-1-H-indol-3-il)2-oxo-3-H-pirrol-3-ilideno] 1,3-dihidro-2Hindol-Z-ona. PI 9702918-1, 1997.
8. DURÁN, N. & FALJONI-ALARIO, A. Bacterial Chemistry- I: Studies of a Potential Phototherapeutic Substance from Chromobacterium violaceum. An. Acad. Brasil. Ciênc., 55: 297302, 1980.
9. DURÁN, N. ERAZO, S. & CAMPOS, Y. Bacterial Chemistry-Il: Antimicrobial photoproduct from pigment of Chromobacterium violaceum. An. Acad. Brasil. Ciênc., 55: 231-234, 1983.
10. DURÁN, N.; CAMPOS, Y.; RIVEROS, R; JOYAS, A.; PEREIRA, M.F. & HAUN, M. Bacterial Chemistry-III: Preliminary Studies on Trypanosomal Activities of Chromobacterium violaceum. An. Acad. Brasil. Ciênc., 61:31-36, 1989.
11. ERICKSSON, H.M. & SHERIS, J.C. Antibiotic sensitivity testing: report for an international collaborative study. Acta Pathol. Microbiol. Scand. [B]Suppl., 217:3-90, 1971.
12. HART, C.A; BEECHING, N.J. & DUERDEN, B.I. Tuberculosis into the next century. J. Med. Microbiol., 44: 1-34, 1996.
13. KOCHI, A. The global tuberculosis situation and the new control strategy of the world Health Organization. Tubercle, 72: 1-6, 1991.
14. LICHSTEIN, H.C. & VAN DE SAND, Y.F.J. Violacein, an antibiotic pigment produced by Chromobacterium violaceum. J. Infect. Dis., 76:47-51, 1945.
15. LICHSTEIN, H.C. & VAN DE SAND, Y.F. The antibiotic activity of violacein, prodigiosin, and phthiocol. J. Bacteriol., 52: 145-146, 1946.
16. LIMA, M.M.; BELLUOMINI, M.; ALMEIDA, M.M.M. & ARANTES, G.R. Co-infecção HIV/tuberculose: necessidade de uma vigilância mais efetiva. Rev. Saúde Públ. S. Paulo, 31:217-20,1997.
17. MUSSER, J .M. Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin. Microbiol. Rev., 8: 496-514, 1995.
18. PARKER, W.L.; RATHNUM, M.L. & JOHNSON, J .H. Aerocyanidin, a new antibiotic produced by Chromobacterium violaceum. J. Antibiot., 41: 454-460, 1988.
19. REITTORI, D. & DURÁN, N. Production, extraction, and purification of violacein: an antibiotic pigment produced by Chromobacterium violaceum. World J. Microbiol. Biothecn.i: in press.
20. SINGH, P.D.; LIU, w.c., GOUGOUTAS, J.Z.; MALLEY, M.F.; PORUBCAN, M.A.; TRElO, W.H.; WELLS, J.S. & SYKES, R. B. Aerocavin, a new antibiotic produced by
Chromobacterium violaceum. J. Antibiot., 41: 446-453, 1988.
21. SNIDER, D. E. & ROOPER, W. L. The new tuberculosis. N. Engl. 1. Med., 326: 703-705, 1992.
22. TSUKAMURA. M. In vitro bacteriostatic and bactericidal activity of isoniazid on the Myco-bacterium avium-Mycobacterium intracellulare complexo Tubercle,71:199-204, 1990.
23. UEDA, H.; MANDA, T.; MATSUMOTO, S.; MUKUMOTO, S.; NISHIGAK1, F.; KAWAMURA,!. & SHIMOMURA, K. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968:III. Antitumor activities on experimental tumors in mice. J. Antibiot., 47:315-323, 1994.
24. WAKSMAN, S.A.; BUGIE, E. & SCHATZ, A. Isolation of antibiotic substance from soil microorganisms with special reference to streptothricin and streptomicin. Mayo Clin Proc., 19: 537-548, 1944.
TOOPS, D.S.; FORD, C.W. & ZURENKO, G.E. Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity. J. Med. Chem., 39: 680-685, 1996.
2. CAMPOS, Y.; ERAZO, S. & DURÁN, N. Novos Fotoprodutos com Atividade Antimicrobiana de Chromobacterium violaceum. Arq. Biol. Tecnol., 25:147, 1982.
3. CENTERS FOR DISEASE CONTROL AND PREVENTION. Estimates of future global tuberculosis morbity and mortality. Morb. Mort. Weekly Rep., 39:1542-1545, 1995.
4. COHN, D.L.; BUSTREO, F. & RAVIGLIONE, M.C. Drug resistant tuberculosis: review of the world wide situation and the WHO/IUATLD Global Surveillance Project. Clin. Infect. Dis., 24:S121-S130, 1997.
5. CYNAMON, M.H.; SPEIRS, RJ. & WELCH, J.T. In vitro antimycobacteria1 activity of 5Chloropyrazinamide. Antimicrob. Agents Chemother., 42:462-463, 1998.
6. DEMOSS, RD. Violacein. Antibiotics. 2: 77-81, 1967.
7. DURÁN, N & HAUN, M. Processo de produção, obtenção, purificação e atividade antitumoral de 3-[1,2-Dihidro-5-(5-hidroxi-1-H-indol-3-il)2-oxo-3-H-pirrol-3-ilideno] 1,3-dihidro-2Hindol-Z-ona. PI 9702918-1, 1997.
8. DURÁN, N. & FALJONI-ALARIO, A. Bacterial Chemistry- I: Studies of a Potential Phototherapeutic Substance from Chromobacterium violaceum. An. Acad. Brasil. Ciênc., 55: 297302, 1980.
9. DURÁN, N. ERAZO, S. & CAMPOS, Y. Bacterial Chemistry-Il: Antimicrobial photoproduct from pigment of Chromobacterium violaceum. An. Acad. Brasil. Ciênc., 55: 231-234, 1983.
10. DURÁN, N.; CAMPOS, Y.; RIVEROS, R; JOYAS, A.; PEREIRA, M.F. & HAUN, M. Bacterial Chemistry-III: Preliminary Studies on Trypanosomal Activities of Chromobacterium violaceum. An. Acad. Brasil. Ciênc., 61:31-36, 1989.
11. ERICKSSON, H.M. & SHERIS, J.C. Antibiotic sensitivity testing: report for an international collaborative study. Acta Pathol. Microbiol. Scand. [B]Suppl., 217:3-90, 1971.
12. HART, C.A; BEECHING, N.J. & DUERDEN, B.I. Tuberculosis into the next century. J. Med. Microbiol., 44: 1-34, 1996.
13. KOCHI, A. The global tuberculosis situation and the new control strategy of the world Health Organization. Tubercle, 72: 1-6, 1991.
14. LICHSTEIN, H.C. & VAN DE SAND, Y.F.J. Violacein, an antibiotic pigment produced by Chromobacterium violaceum. J. Infect. Dis., 76:47-51, 1945.
15. LICHSTEIN, H.C. & VAN DE SAND, Y.F. The antibiotic activity of violacein, prodigiosin, and phthiocol. J. Bacteriol., 52: 145-146, 1946.
16. LIMA, M.M.; BELLUOMINI, M.; ALMEIDA, M.M.M. & ARANTES, G.R. Co-infecção HIV/tuberculose: necessidade de uma vigilância mais efetiva. Rev. Saúde Públ. S. Paulo, 31:217-20,1997.
17. MUSSER, J .M. Antimicrobial agent resistance in mycobacteria: molecular genetic insights. Clin. Microbiol. Rev., 8: 496-514, 1995.
18. PARKER, W.L.; RATHNUM, M.L. & JOHNSON, J .H. Aerocyanidin, a new antibiotic produced by Chromobacterium violaceum. J. Antibiot., 41: 454-460, 1988.
19. REITTORI, D. & DURÁN, N. Production, extraction, and purification of violacein: an antibiotic pigment produced by Chromobacterium violaceum. World J. Microbiol. Biothecn.i: in press.
20. SINGH, P.D.; LIU, w.c., GOUGOUTAS, J.Z.; MALLEY, M.F.; PORUBCAN, M.A.; TRElO, W.H.; WELLS, J.S. & SYKES, R. B. Aerocavin, a new antibiotic produced by
Chromobacterium violaceum. J. Antibiot., 41: 446-453, 1988.
21. SNIDER, D. E. & ROOPER, W. L. The new tuberculosis. N. Engl. 1. Med., 326: 703-705, 1992.
22. TSUKAMURA. M. In vitro bacteriostatic and bactericidal activity of isoniazid on the Myco-bacterium avium-Mycobacterium intracellulare complexo Tubercle,71:199-204, 1990.
23. UEDA, H.; MANDA, T.; MATSUMOTO, S.; MUKUMOTO, S.; NISHIGAK1, F.; KAWAMURA,!. & SHIMOMURA, K. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968:III. Antitumor activities on experimental tumors in mice. J. Antibiot., 47:315-323, 1994.
24. WAKSMAN, S.A.; BUGIE, E. & SCHATZ, A. Isolation of antibiotic substance from soil microorganisms with special reference to streptothricin and streptomicin. Mayo Clin Proc., 19: 537-548, 1944.
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 1999 Ana Olivia de Souza, Dalva Cristina Girello Aily, Daisy Nakamura Sato, Nelson Durán
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