Keywords
transformation
opsonization
capsule
How to Cite
Abstract
The capsular switching process indicates the action of specific capsular antibodies on the meningococcal strains adaptation. Different antibodies were employed for assessing the effect of opsonization on the transformation of Neisseria meningitidis serogroups C and W135. These analyses showed the blocking action of the specific capsular antibodies on the meningococcal transformation capacity. Thus, the blocking effect of these antibodies on N. meningitidis transformation process was demonstrated. This effect could be involved in the capsular switching process and the found data might open new subjects for scientific exploration.References
1. Dubnau D. DNA uptake in bacteria. An Rev Microbiol. 1999;53:217-44.
2. Tortosa P, Dubnau D. Competence for transformation: a matter of taste. Curr Opin Microbiol. 1999;2(6):588-92.
3. Perez-Trallero E, Vicente D, Montes M, Cisterna R. Positive effect of meningococcal C vaccination on serogroup replacement in Neisseria meningitidis. Lancet. 2002;21;360(9337):953.
4. Taha MK, Parent Du Chatelet I, Schlumberger M, Sanou I, Djibo S, de Chabalier F, et al. Neisseria meningitidis serogroups W135 and A were equally prevalent among meningitis cases occurring at the end of the 2001 epidemics in Burkina Faso and Niger. J Clin Microbiol. 2002;40(3):1083-4.
5. Hollanda LM, Cury GC, Pereira RF, Ferreira GA, Sousa A, Sousa EM, et al. Effect of mesoporous silica under Neisseria meningitidis transformation process: environmental effects under meningococci transformation. J Nanobiotechnol. 2011;9:28.
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