Keywords
nephropathy
urinary albumin
glycated hemoglobin
creatinine
How to Cite
Abstract
Diabetic nephropathy (DN) is a common renal disease associated with diabetes mellitus (DM), and
hyperglycemia is associated with the development of glomerular lesions. This study evaluated the rate of
HbA1c in patients with nephropathy and in those without nephropathy. Glucose, total cholesterol, HDLcholesterol,
LDL-cholesterol, triglycerides, creatinine, glomerular filtration rate (GFR), HbA1c and urinary
albumin contents were determined in 50 diabetic type 2 patients without nephropathy and in 57 patients
with nephropathy. The HbA1c in patients without and with nephropathy were 6.4 ± 0.1% and 7.0 ± 0.1%,
respectively. In addition, the urinary albumin contents were higher in ND group (62.7 ± 7.3 mg/L versus 7.4
± 0.7 mg/L, P<0.001), while GFR values were lower in ND patients than in patients without nephropathy
(67.9 ± 2.5 mL/min/1.73 m2 versus 77.4 ± 2.3 mL/min/1.73 m2, P<0.01). No significant differences were
observed for glucose and lipid profile. The highest rates of HbA1c were detected in patients with DN, and
these findings support the use of this biomarker for diabetes control and for monitoring the patients and
to prevent them from getting diabetes-associated diseases.
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Copyright (c) 2010 Instituto Adolfo Lutz Journal
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