Review on the occurrence of uterine cervix lesions according to age group among women enrolled in the Viva Mulher – Prevention Program during the period from 2004 to 2008
PDF (Português (Brasil))

Keywords

cytology screening
cervical smears
Pap test
age group

How to Cite

1.
Yamamoto LSU, Pereira SMM, Etlinger D, Aguiar LS, Sakai YI, Shirata NK, Teixeira M dos S, Loreto C di. Review on the occurrence of uterine cervix lesions according to age group among women enrolled in the Viva Mulher – Prevention Program during the period from 2004 to 2008. Rev Inst Adolfo Lutz [Internet]. 2009 Jan. 1 [cited 2024 Jul. 22];68(1):126-32. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/32752

Abstract

The retrospective study on cervico-vaginal smears analyzed by Papanicolaou (Pap) test at Instituto Adolfo Lutz – Division of Pathology, during the period from 2003 to 2008, was carried out. The diagnoses of pre-neoplasic and neoplasic lesions on Pap smears were analyzed, according to the age groups distribution. Of the 222,024 analysed samples, 3,674 (1.65%) were classified as unsatisfactory, 206,439 (92.98%) were negative and 11,911 (5.36%) presented abnormal cytology diagnoses. Of those with abnormal cytology, 6,437 (54.04%) were classified as ASC-US, 210 (1.76%) as ASC-H, 3,264 (27.40%) as LSIL, 1,279 (10.74%) as HSIL, 131(1.10%) as SCC and 552 (4.63%) as AGC-US, 23 (0.19%) as AGC-H, 7 (0.06%) as AIS, and 8(0.07%) were diagnosed as ADENOCA. The distribution of the squamous and glandular intraepithelial lesions diagnosis in the age group ranging at 5-year intervals, showed the major frequency of LSIL among younger women (15-25 years of age), and the diagnoses of ASC-US, ASC-H, AGC-US, HSIL, SCC and ADENOCA among >50 year- old women. The glandular variations as AGC-H and AIS occurred in women at of 30-34 and 45-49 age groups. Two (0.16%) women with HSIL were under 14 years of age, and 51 (3.99%) were from 15 to 19 years old. This study emphasizes the relevance in implementing the educational campaigns, the patients screening and follow-up protocols for assuring the improvement and the effectiveness of prevention programs.
https://doi.org/10.53393/rial.2009.68.32752
PDF (Português (Brasil))

References

1. Ministério da Saúde. Instituto Nacional de Câncer. Estimativas da incidência e mortalidade do câncer no Brasil. 2008, Rio de Janeiro [acesso em 24/04/09). Disponível em: http://www.inca.gov.br/estimativas/2008/

2. Ferlay JFB, Pisaniand P, Parkin DM. GLOBOCON 2002: cancer incidence, mortality and prevalence worldwide. IARC CancerBase Nº 5, Version 2.0 Lyon: IARC Press, 2004.

3. WHO. Control of cancer of cervix uteri. A WHO meeting. Bull WHO 1986; 64: 761-9.

4. Ministério da Saúde. Secretaria Nacional de Assistência à Saúde. Instituto Nacional de Câncer. Consenso de periodicidade e faixa etária no exame de prevenção do câncer cérvico-uterino, 1988. Rev Bras Cancerol. 1989; 35(1/2):77.

5. Peto J, Gilham C, Fletcher O, Matthews FE. The cervical cancer epidemic that screening has prevented in the UK. Lancet. 2004; 364(9430): 249-58.

6. Calazan C, Luis RR, Ferreira I. O diagnóstico do cancer do colo uterino invasor em um Centro de Referencia Brasileiro: Tendência temporal e potenciais fatores relacionados. Rev Bras Cancerol. 2008; 54(4): 325-31.

7. Hankey BF, Ries LA, Edwards BK. The surveillance, epidemiology, and end results program. A National Resource. Cancer Epidemiol Biomarkers & Prev. 1999; 8: 1117-21.

8. Nanda K, Mccrory DC, Myers ER, Bastian LA, Hasselblad V, Hickey JD, Matchar DB. Accurary of the Papanicolaou test in screnning for and follow-up of cervical cytologic abnormalities. Ann Intern Med. 2000, 132(10): 810-9.

9. Fahey MT, Irwig L, Macaskill P. Meta-analysis of Pap test accuracy. Am J Epidemiol. 1995; 141: 680-9.

10. Renshaw AA. Accurate and precise methodologies for routine determination of false-negative rate of Papanicolaou smear screening Cancer Cytopathol. 2001; 93: 86-92.

11. Ferraz MGMC, Agnol MD, di Loreto C, Pirani WM, Utagawa ML, Pereira SMM, Sakai YI, Feres CL, Shih LWS, Yamamoto LSU, Rodrigues ROL, Shirata NK, Longatto-Filho A. 100% rapid rescreening for quality assurance in a quality control program in a public health cytology laboratory. Acta Cytol. 2005; 49(6): 639-43.

12. Ministério da Saúde. Prevenção do câncer do colo do útero. Manual Técnico para Laboratórios. Brasília (DF); 2002.

13. Tavares SBN, Amaral RG, Manrique EJC, Sousa NLA, Albuquerque ZBP, Zeferino LC. Controle de qualidade em citopatologia cervical: revisão de literatura. Rev Bras Cancerol. 2007; 53(3): 355-64.

14. CLIA 88: Centers for Disease Control: regulations for implementating clinical laboratory improvement of 1988: A summary. J Am Med Assoc. 1992; 267: 1725-34.

15. Pereira SMM, Ramos DEL, Yamamoto LSU, Shirata NK, di Loreto C, Ferraz MGMC, Longatto-Filho A e grupo de cols. Monitoramento externo de qualidade em citopatologia cervical e o refl exo na rotina dos laboratórios da rede pública. DST – J bras Doenças Sex Transm 2006; 18(3): 172-7.

16. Instituto Nacional do Câncer/Ministério da Saúde. Nomenclatura brasileira para laudos cervicais e condutas preconizadas: recomendações para profi ssionais de saúde J Bras Patol Med Lab. 2006; 42(5): 351-73.

17. Gupta S, Sodhani P, Halder K, Chachra KL, Singh V, Sehgal A. Age trends in pre-cancerous and cancerous lesions of the uterine cervix in a cytology screening programm: what should be the target age group for a major thrust of screening in resource-limited settings. Cytopathol 2008; 19: 106-10.

18. Instituto Nacional de Câncer. Implantando o Viva Mulher – Programa Nacional de Controle do Câncer do Colo do Útero e de Mama. Rio de Janeiro (Brasil): Instituto Nacional de Cancer; 2001.

19. Ducatti C, Ramos DEL, Gomes LP, Aguiar LS. Não-conformidades em exames citopatológicos: um problema no diagnóstico precoce do câncer de colo uterino. J Bras Patol Med Lab. 2008; 44(2): 116.

20. Pereira SMM, Yamamoto LSU, di Loreto C, Silva LA, Makabe S, Marques JA, Maeda MYS, Santoro CL, Utagawa ML, Longatto-Filho A. O impacto do diagnóstico citológico de atipias indeterminadas no Sistema Público de Saúde. DST – J bras Doenças Sex Transm 2005; 17(4): 251-4.

21. Yamamoto LSU, Saito S, Pereira SMM, Utagawa ML, Longatto-Filho a. Uterine Cytopathology in a public health laboratory: impact from 20 years data (1984-2003). Rev Inst Adolfo Lutz. 2006; 65(2): 141-5.

22. Etlinger DLR, Pereira, SMM, Oikawa KF, Marin AC, Araujo RS, Souza CJ, Yamamoto LSU. Campanha de prevenção de câncer cervical: estudos no Instituto Adolfo Lutz mostram a necessidade de avaliação na faixa etária. Rev Inst Adolfo Lutz. 2008; 67(1): 64-8.

23. Cabral MDB, Feitosa TMP, Figueiredo RM, Almeida RT. Análise do rastreamento do câncer do colo do útero no Estado do Rio de Janeiro. 2008. 21º Congresso Brasileiro de Engenharia Biomédica.

24. Barret D, Schepansky A, Capstick V, Johnson G, Steed H, Faught W. Atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): A result not to be ignored. Gynecol. 2006; 1095-8.

25. Rader AE, Rose PG, Rodriguez M, Mansbacher S, Pitlik D, Abdul-Karim FW. Atypical squamous cells of undetermined signifi cance in women over 55. Comparison with the general population and implications for management. Acta Cytol 1999; 43(3): 357-62.

26. Kaminski PF, Stevens CWJ, Wheelock JB. Squamous atypia on cytology. The infl uence of age. J Reprod Med. 1989; 34: 617-20.

27. Longatto-Filho A, Etlinger D, Gomes NS, Cruz SV, Cavalieri MJ. Frequencia de esfregaços cérvico-vaginais anormais em adolescentes e adultas: revisão de 308.630 casos. Rev Inst Adolfo Lutz. 2003; 62(1): 31-4.

28. Ault KA. Epidemiology and natural history of human papillomavirus infections in the female genital tract. Infect Dis Obstet Gynecol. 2006; 14; 40470.

29. Franco EL, Duarte-Franco E, Ferenczy A. Cervical cancer: epidemiology, prevention and role of human papillomavirus infection. Can Med Assoc J. 2001; 164(7): 1017-25.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2009 Instituto Adolfo Lutz Journal

Downloads

Download data is not yet available.