Abstract
Bisphenol A is an industrial compound produced in large scale around the world. This product is used for manufacturing the synthetic polymers, including epoxy resins, which are applied for varnishing the both internal and external parts of food cans, and also for producing the polycarbonate applied on baby bottles and bottles of water. Other less significant applications are the production of polyvinyl chloride (PVC), to manufacture the thermal paper, polyurethane, polyamide, flame retardant, and to prepare the dental sealants and resins. Bisphenol A is considered as an endocrine disruptor that interferes with the production, release, transport, metabolism, binding or elimination of natural hormones responsible for maintaining balance and regulation of development processes. Among the various routes of human exposure to bisphenol A, the dietary exposure is especially worrisome as it potentially reaches higher number of persons in the different age groups, besides, it may occur during long periods in low doses and without being detected. This review aimed at addressing the routes of exposure to bisphenol A, its toxicity and the legislations concerning their limits to ensure the human health integrity.References
1. Murata LTF, Nunes MCD, Alcântara MRS, Pascuet NS, Bernardo PEM. Embalagens destinadas a alimentos. In: Germano PML, Germano MIS (organizadores). Higiene e Vigilância Sanitária de Alimentos. São Paulo: Editora Manole Ltda. 2011.p.709-59.
2. Fasano E, Bono-Blay F, Cirillo T, Montuori P, Lacorte S. Migration of phthalates, alkylphenols, bisphenol A and di(2-ethylhexyl) adipate from food packaging. Food Control. 2012; 27(1): 132-8. doi:10.1016/j.foodcont.2012.03.005
3. Huang YQ, Wong CKC, Zheng JS, Bouwman H, Barra R, Wahlstrom B, et al. Bisphenol A (BPA) in China: A review of sources, environmental levels, and potential human health impacts. Environ Int. 2012; 42: 91-9. doi:10.1016/j.envint.2011.04.010
4. Encarnação IPMF. Estudos de migração do bisfenol A em biberões [dissertação de mestrado]. Lisboa (PT): Universidade de Lisboa; 2007.
5. Michalowicz J. Bisphenol A - Sources, toxicity and biotransformation. Environ Toxicol Phar. 2014; 3 (2):738-58.doi:10.1016/j.etap.2014.02.003
6. EU. European Union Risk Assessment Report.Bisphenol A, CAS Nº:80-05-7. Institute for Health and Consumer Protection, European Chemicals Bureau, European Commission Joint Research Centre, 3rd Priority List, Luxembourg: Office for Official Publications of the European Communities. 2003. [acesso 2014 Jun 05].Disponível em: [http://www.oehha.org/prop65/crnr_notices/state_listing/data_callin/pdf/EU_bisphenolareport325.pdf].
7. Flint S, Markle T, Thomson S, Wallace E. Bisphenol A exposure effects and policy; a wildlife perspective. J Environ Manage. 2012; 104:19–34. doi: 10.1016/j.jenvman.2012.03.021
8. Maia J, Cruz JM, Sendón R, Bustos J, Cirugeda ME, Sanches JJ, et al. Effect of amines in the release of bisphenol A from polycarbonate baby bottles. Food Res Int. 2010; 43(5): 1283-8. doi:10.1016/j.foodres.2010.03.014
9. Beserra MR, Schiavini JA, Rodrigues WC, Pereira CSS. O Bisfenol A: sua utilização e a atual polêmica em relação aos possíveis danos à saúde humana. Rev Eletr TECCEN. 2012; 5(1): 37-46.
10. Nam S-H, Seo Y-M, Kim M-G. Bisphenol A migration from polycarbonate baby bottle with repeated use. Chemosphere. 2010; 79(9): 949-52. doi:10.1016/j.chemosphere.2010.02.049
11. Perez MAF. O bisfenol A e as legislações para contato com alimentos. Bol Tecnol Desenv Embalagens. 2012; 24(2): 5p. Disponível em: [http://www.cetea.ital.sp.gov.br/informativo/v24n2/v24n2_artigo2.pdf ].
12. Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol A (BPA). Reprod Toxicol. 2007; 24(2):139–77. doi:10.1016/j.reprotox.2007.07.010
13. European Food Safety Authority (EFSA). Scientific opinion on bisphenol A: evaluation of a study investigating its neurodevelopment toxicity, review of recent scientific literature on its toxicity and advice on the Danish risk assessment of Bisphenol A. EFSA Journal. 2010; 8(9): 1829, 116p. [acesso 2014 Jun 13]. Disponível em: [http://www.efsa.europa.eu/de/scdocs/doc/1829.pdf ].
14. Saron ES. Estabilidade de suco de maracujá acondicionado em embalagens de aço com diferentes revestimentos orgânicos [dissertação de mestrado]. Campinas (SP): Universidade Estadual de Campinas; 2004.
15. Cao XL, Corriveau J, Popovic S. Levels of bisphenol A in canned soft drink products in Canadian Markets. J Agric Food Chem. 2009; 57(4): 1307-11. doi: 10.1021/jf803213g
16. Marical-Arcas M, Rivas A, Granada A, Monteagudo C, Murcia MA, Olea-Serrano F. Dietary exposure assessment of pregnant womem to bisphenol-A from cans and microwave containers in Southern Spain. Food Chem Toxicol. 2009; 47(2): 506-10. doi: 10.1016/j.fct.2008.12.011
17. Noda M, Komatsu H, Sano H. HPLC analysis of dental resin composites components. J Biomed Mater Res. 1999; 47(3): 374-8. doi: 10.1002/(SICI)1097-4636(19991205)47:3<374
18. Wilson NK, Chuangb JC, Morgan MK, Lordo RA, Sheldon LS. An observational study of the potential exposures of preschool children to pentachlorophenol, bisphenol A and nonylphenol at home and daycare. Environ Res. 2007; 103(1): 9–20. doi:10.1016/j.envres.2006.04.006
19. Geens T, Aerts D, Berthot C, Bourguignon JP, Goeyens L, Lecomte P, et al . A review of dietary and non-dietary exposure to bisphenol A. Food Chem Toxicol. 2012; 50(10): 3725-40. doi: 10.1016/j.fct.2012.07.059
20. Krishnan AV, Sthathis P, Permuth SF, Tokes L, Feldman D. Bisphenol A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology.1993; 132(6): 2279-86. doi: http://dx.doi.org/10.1210/endo.132.6.8504731
21. Biles JE, McNeal TP, Begley TH, Hollifield HC. Determination of bisphenol A in reusable polycarbonate food-contact plastics and migration to food-simulating liquids. J Agric Food Chem.1997; 45(9): 3541-4. doi: 10.1021/jf970072i
22. Biles JE, McNeal TP, Begley TH. Determination of bisphenol A migrating from epoxy can coatings to infant formula liquid concentrates. J Agric Food Chem.1997; 45(12): 4697-700. doi: 10.1021/jf970518v
23. Thomson BM, Grounds PR. Bisphenol A in canned foods in New Zealand: An exposure assessment. Food Addit Contam. 2005; 22(1):65-72. doi: 10.1080/02652030400027920
24. Cabado AG, Aldea S, Porro C, Ojea G, Lago J, Sobrado C, et al. Migration of BADGE (bisphenol A diglycidyl-ether) and BFDGE (bisphenol F diglycidyl-ether) in canned seafood. Food Chem Toxicol. 2008; 46(5):1674-80. doi:10.1016/j.fct.2008.01.006
25. Bem-Jonathan N, Steinmetz R. Xenoestrogens: the emerging story of bisphenol A. Trends Endocrinol Metab. 1998; 9(3): 124-8. doi:10.1016/S1043-2760(98)00029-0
26. Le HH, Carlson EM, Chua JP, Belcher SM. Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons. Toxicol Lett. 2008; 176(2): 149-56. doi: 10.1016/j.toxlet.2007.11.001
27. Welshons WV, Nagel SC, vom Saal FS. Large effects from small exposures.III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology. 2006; 147(6): S56-69. doi: http://dx.doi.org/10.1210/en.2005-1159
28. Maffini MV, Rubin BS, Sonnenschein C, Soto AM. Endocrine disruptors and reproductive health: the case of bisphenol A. Mol Cell Endocrinol.2006; 254-255:179-86. doi:10.1016/j.mce.2006.04.033
29. Mercea P. Physicochemical processes involved in migration of bisphenol A from polycarbonate. J Appl Polym Sci. 2009; 112(2): 579-93. doi: 10.1002/app.29421
30. Jetten J, Kruijf N. Quality and safety aspects of reusable plastic food packaging materials: influence of reuse on intrinsic properties. Food Addit Contam. 2002; 19(1): 76-88. doi: 10.1080/02652030110071309
31. World Health Organization – WHO. Toxicological and Health Aspects of Bisphenol A Report of Joint FAO/WHO Expert Meeting. 2010. [acesso 2014 Nov 25]. Disponível em: [http://whqlibdoc.who.int/publications/2011/97892141564274_eng.pdf ].
32. Takao Y, Lee HC, Kohra S, Arizono K. Release of bisphenol A from food can lining upon heating. J Health Sci. 2002; 48(4): 331-4.
33. Rogers JA, Metz L, Yong VW. Review: Endocrine disrupting chemicals and immune responses: A focus on bisphenol-A and its potential mechanisms. Mol Immunol. 2013; 53(4): 421-30. doi: 10.1016/j.molimm.2012.09.013
34. Rochester JR. Bisphenol A and human health: A review of the literature. Reprod Toxicol. 2013; 42:132-55. doi:10.1016/j.reprotox.2013.08.008
35. Ballesteros-Gómez A, Rubio S, Pérez-Bendito D. Analytical methods for the determination of bisphenol A in food. J Chromatogr A. 2009; 1216(3): 449-69. doi: 10.1016/j.chroma.2008.06.037
36. Hassan ZK, Elobeid MA, Virk P, Omer SA, ElAmin M, Daghestani MH, et al. Bisphenol A induces hepatotoxicity through oxidative stress in rat model. Oxid Med Cell Longev. 2012; ID 194829, 6 p. doi:10.1155/2012/194829
37. Olsén L, Lind L, Lind PM. Associations between circulating levels of bisphenol A and phthalate metabolites and coronary risk in the elderly. Ecotoxicol Environ Saf. 2012; 80: 179-83. doi: 10.1016/j.ecoenv.2012.02.023.
38. Vom Saal FS, Nagel SC, Coe BL, Angle BM, Taylor JA. The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Mol Cell Endocrinol. 2012; 354(1-2): 74-84. doi: 10.1016/j.mce.2012.01.001
39. Doerge DR, Twaddle NC, Vanlandingham M, Fisher JW. Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats. Toxicol Appl Pharmacol. 2010; 247(2): 158–65. doi: 10.1016/j.taap.2010.06.008
40. Doerge DR, Twaddle NC, Woodling KA, Fisher JW. Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys. Toxicol Appl Pharmacol. 2010; 248(1): 1–11. doi: 10.1016/j.taap.2010.07.009
41. Völkel W, Bittner N, Dekant W. Quantitation of bisphenol A and bisphenol A glucuronide in biological samples by high performance liquid chromatography-tandem mass spectrometry. Drug Metab Dispos. 2005; 33(11): 1748-57. doi:10.1124/dmd.105.005454
42. Calafat AM, Ye X, Wong L-Y, Reidy JA, Needham LL. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect. 2008; 116(1): 39-44. doi: 10.1289/ehp.10753
43. Kuruto-Niwa R, Tateoka Y, Usuki Y, Nozawa R. Measurement of bisphenol A concentrations in human colostrum. Chemosphere. 2007; 66(6): 1160-4. doi:10.1016/j.chemosphere.2006.06.073
44. Tominaga T, Negishi T, Hirooka H, Miyachi A, Inoue A, Hayasaka I, et al. Toxicokinetics of bisphenol A in rats, monkeys and chimpanzees by the LC-MS/MS method. Toxicology. 2006; 226(2-3): 208-17. doi:10.1016/j.tox.2006.07.004
45. Tsutsumi O. Assessment of human contamination of estrogenic endocrine-disrupting chemicals and their risk for human reproduction. J Steroid Biochem Mol Biol. 2005; 93(2-5): 325-30. doi:10.1016/j.jsbmb.2004.12.008
46. Genuis SJ, Beesoon S, Birkholz D. Lobo RA. Human excretion of bisphenol A: blood, urine, and sweat (BUS) study. J Environ Public Health. 2012; ID 185731: 10p. doi: 10.1155/2012/185731
47. Vandenberg LN, Maffini MV, Sonnenschein C, Rubin BS, Soto AM. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocr Rev 2009; 30(1):75-95. doi: 10.1210/er.2008-0021
48. Vandenberg LN, Ehrlich S, Belcher SM, Ben-Jonathan N, Dolinoy DC, Hugo ER , et al. Low dose effects of bisphenol A. An integrated review of in vitro, laboratory animal, and epidemiology studies. Endocr Disrup. 2013; 1(1): e25078-1-20. doi: 10.4161/endo.26490
49. Teeguarden JG, Hanson-Drury S. A systematic review of bisphenol A “low dose” studies in the context of human exposure: a case for establishing standards for reporting “low-dose” effects of chemicals. Food Chem Toxicol. 2013; 62: 935-48. doi: 10.1016/j.fct.2013.07.007
50. União Européia (UE). Comissão das Comunidades Européia. Regulamento Nº 08/2011, de 28 de janeiro de 2011. Modifica la Directiva 2002/72/CE no que se refere a restrição do uso de bisfenol A em mamadeiras de plástico para lactantes. Jornal Oficial [da] União Européia. Bruxelas, L 26, 29 jan. 2011. 4p.
51. União Européia (UE). Comissão das Comunidades Européia. Regulamento Nº 10/2011, de 14 de janeiro de 2011. Relativo aos materiais e objetos de matéria plástica destinados a entrar em contato com os alimentos. Jornal Oficial [da] União Européia. Bruxelas, L 12, 15 jan. 2011. 89p.
52. União Européia (UE) Comissão das Comunidades Européia. Regulamento de Execução Nº 321/2011, de 01 de abril de 2011. Altera o Regulamento (UE) Nº 10/2011 no que respeita à restrição da utilização de bisfenol A em mamadeiras de plástico. Jornal Oficial [da] União Européia. Bruxelas, L 87, 02 abr. 2011. 2p.
53. U.S. Food and Drug Administration (FDA). Update on bisphenol A for use in food contact applications.Jan.2010; 7p. [acesso em 2014 jun 05]. Disponível em: [http://www.fda.gov/downloads/NewsEvents/PublicHealthFocus/UCM197778.pdf ]
54. U.S. Food and Drug Administration (FDA). FDA Consumer Health Information. FDA continues to study BPA. March. 2012; 2p. [acesso em 2014 nov 26]. Disponível em: [http://www.fda.gov/downloads/ForConsumers/ConsumerUpdates/UCM297971.pdf]
55. Brasil. Agência Nacional de Vigilância Sanitária. Resolução RDC nº 17, de 17 de março de 2008. Dispõe sobre regulamento técnico sobre lista positiva de aditivos para materiais plásticos destinados à elaboração de embalagens e equipamentos em contato com alimentos. Diário Oficial [da] República Federativa do Brasil, Brasília, DF, 18 mar. 2008. Seção 1, p. 43-51.
56. Grupo Mercado Comum Mercosul/GMC/Res. nº 32/2007. Regulamento Técnico Mercosul sobre lista positiva de aditivos para materiais plásticos destinados à elaboração de embalagens e equipamentos em contato com alimentos. Montevidéu, 11 dez. 2007. Disponível em: [http://www.mercosur.int/innovaportal/v/595/1/secretaria/resoluciones_2007]
57. Brasil. Agência Nacional de Vigilância Sanitária. Resolução RDC nº 41, de 16 de setembro de 2011. Dispõe sobre a proibição de uso de bisfenol A em mamadeiras destinadas a alimentação de lactantes e dá outras providências. Diário Oficial [da] República Federativa do Brasil, Brasília, DF, 19 set. 2011. Seção 1, nº 180. p. 54.
58. Brasil. Agência Nacional de Vigilância Sanitária. Resolução RDC nº 56, de 16 de novembro de 2012. Dispõe sobre a lista positiva de monômeros, outras substâncias iniciadoras e polímeros autorizados para a elaboração de embalagens e equipamentos plásticos em contato com alimentos. Diário Oficial [da] República Federativa do Brasil,Brasília, DF, 21 nov. 2012. Seção 1, nº 224. p.66-77.
59. Grupo Mercado Comum. Mercosul/GMC/Res. nº 02/2012. Regulamento Técnico Mercosul sobre a lista positiva de monômeros, outras substâncias iniciadoras e polímeros autorizados para a elaboração de embalagens e equipamentos plásticos em contato com alimentos. Buenos Aires,19 abr. 2012. Disponível em: [http://www.mercosur.int/innovaportal/v/4151/1/secretaria/resoluciones_2012]
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2015 Instituto Adolfo Lutz Journal