Quantitative determination of active principle and evaluation of the dermal and ocular safety to treatment of ectoparasitosis products containing lindane
Vol. 60 No. 2 (2001), SCIENTIFIC COMMUNICATION
Vol. 60 No. 2 (2001)

Quantitative determination of active principle and evaluation of the dermal and ocular safety to treatment of ectoparasitosis products containing lindane

SCIENTIFIC COMMUNICATION
https://doi.org/10.53393/rial.2001.60.35922
Published 2001-05-03
Lígia L. Miyamaru
Seção de Cosméticos e Produtos de Higiene – Divisão de Bromatologia Química – Instituto Adolfo Lutz – São Paulo.
Maria Cristina Santa-Bárbara
Seção de Cosméticos e Produtos de Higiene – Divisão de Bromatologia Química – Instituto Adolfo Lutz – São Paulo.
Maria Helena Iha
Laboratório I de Ribeirão Preto – Instituto Adolfo Lutz.
Deusdete A. Teixeira
Bolsista FEDIAL.
Odair Zenebon
Divisão de Bromatologia e Química – Instituto Adolfo Lutz – São Paulo.
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Keywords

Lindane, treatment of ectoparasitosis products, safety.

How to Cite

1.
L. Miyamaru L, Santa-Bárbara MC, Iha MH, A. Teixeira D, Zenebon O. Quantitative determination of active principle and evaluation of the dermal and ocular safety to treatment of ectoparasitosis products containing lindane. Rev Inst Adolfo Lutz [Internet]. 2001 May 3 [cited 2024 Nov. 23];60(2):159-62. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/35922
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Abstract

The aim of this study was the quantification of the drug as well as dermal and ocular safety evaluation in samples containing 1% lindane (w/w), that are used in the treatment of ectoparasitosis: pediculosis and scabies. Six samples were analyzed: a shampoo, a cream, two bars of toilet soap and two lotions of different brands. The quantification method was described in the United States Pharmacopeia, 1995. Tests of dermal and ocular irritation using the method of Draize with modification were done in samples and lindane alcoholic solutions in different concentrations. In samples, also the test was done according to the manufacturer’s directions for use and composition. The results of the lindane quantification showed that the analyzed samples were in accordance with the label. The results of the toxicological tests showed that, when applied according to manufacturer’s directions, the products using did not damage the skin or the eyes of the animal. However, when the samples were submitted to the cumulative dermal test, implying repeated application of the product, they showed dermal irritation. So the incorrect use was proved to cause skin damage and compromise the customers’s health due to the lindane toxicity.

https://doi.org/10.53393/rial.2001.60.35922
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