Keywords
diethylpropion
fenproporex
formulas for slim
How to Cite
Abstract
This present study describes a gas chromatography method for simultaneous determination of diethylpropion and fenproporex that are present in formulas indicated for weight loosing diets. This method was applied in three different formulas, consisting of drugs, in a range of quantities most commonly prescribed. The method consisted of amphetamines extraction with methylene chloride, followed by gas chromatography analysis, using phenylpropanolamine as an internal standard. The separation between the two substances was observed, with a retention time of 3,7 minutes for diethylpropion and 4,3 minutes for fenproporex. The maximum variation coefficient for the diethylpropion method was 2,28% and for the fenproporex it was 2,41 %.
References
2. BERQUÓ, E.S.; SOUZA, I.M.P. & GOTLIEB,S.L.D. - Bioestatística. 1ª ed. rev., São Paulo, Editora Pedagógica e Universitária Ltda. 1981, p.69-98.
3. BRASIL. Leis, Decretos etc - Portaria n o 344, de 12 de maio de 1998, da Secretaria de Vigilância Sanitária, do Ministério da Saúde. Diário Oficial da União, Brasília, 19 de maio de 1998.Seção I, p. 37. Aprova o Regulamento Técnico sobre substâncias e medicamentos sujeitos a controle especial.
4. CHAVES, M.A.; AKATUKA, A.S. & TRUIILLO, L.M. - Dietilpropiona, femproporex, diazepam e fenolftaleína: determinação em formulações para emagrecimento. Rev. Inst. Adolfo Lutz; 54(1):36-43, 1994.
5. CLARKE'S - Isolation and identification of drugs. 2nd ed., London, The Pharmaceutical Press, 1986, p. 526-527,538-539,617.
6. GOODMAN AND GILMAN' S The Pharmacological basis of therapeutics. 8th ed., New York, Pergamon Press, 1990, p. 187-218, 428-429,920-921.
7. LEACH, H & RAMSEY, I.D. Gas chromatography. ln: CLARKE'S. Isolation and identification of drugs. 2nd ed. London, The Pharmaceutical Press, 1986, p. 178-200.
8. MANSON, J.E. & FAICH, G.A. - Pharmacotherapy for obesity - Do the benefits outweigh the risks? The New England Journal of Medicine, 335(9): 659-660, 1996.
9. MARTINDALE - The extra pharmacopeia. 31st ed., London, Royal Pharmaceutical Society, 1996. p. 700-707,1549-1550,1552.
10. MEDEIROS NETO, G. - Tratamento farmacológico da obesidade: a necessidade de uma revisão científica e filosófica. Rev. Ass. Med. Brasil, 39(4):257-259, 1993.
11. SCHVARTSMAN, S. - Intoxicações agudas. 4ª ed., São Paulo, Sarvier Editora de Livros Médicos Ltda, 1991, p. 34,75-76,84-85.
12. WILSON, C.O.; GISVOLD, O. & DOERG, R.F. Textbook of organic medicinal and pharmaceutical chemistry. 7th ed. Philadelfia, J.B. Lippincott Company, 1977, p. 374-377, 416420, 952-954.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 1999 Instituto Adolfo Lutz Journal