Keywords
antibodies
anti-reticuJin antibodies in Manson's sch is tossomiasis
mice
white
anti-reticulin antibodies in sera
frequency
How to Cite
Abstract
The rate of occurrence of anti-reticulin antibodies in sera irom S. mansoni-experimentally infected albino mice was ínvestigated, in order to evaluate its arising and reactivity intensity, according to the infection period of time. Indirect immunofluorescence technique on criostat sections of urifí xed snap-frozen human kidney was employed. Forty-eight (96%) of 50 mice with S. mansoni infection exibited positive reactions in variable intensity; 31 (64.5%) sera showed faint staining while brighter staining was shown by 17 (35.5%). Among 10 non-infected mice group, there was virtually no staining. Among the infected mice g roup, a greater reactivity was observed in chronicalJy infected mice, supporting the hypothesis of a relationship between rnesenquimal alterations and
the presence of anti-reticulin antibodies.
References
2. COSSIO, P.M.: DIEZ, C.; SZARFMAN, A.; KREUTZER, E.; CANDIOLO, B. & ARANA, R.M. - Chagasic cardiopathy. Demonstration of a serum gammaglobulin facto r which reacts with endocardium and vascular structures. Circulation, 49: 13-21, 1974.
3. COSSIO, P.M.; LAGUENS, R.P.; DIEZ, C.; SZARFMAN, A.; SEGAL, A. & ARANA, R.M. - Chagasic cardiopathy. Antibodies reacting with plasma membrane of striated muscle and endothelial cells. Circulation, 50: 1252-9, 1974.
4. HUBSCH, R.M.; SULZER, A.J. & KAGAN, LG. - Evaluation of an autoimmune type antibody in the sera of patients with Chagas' disease. J. Parasit., 62 :523-7, 1976.
5. JOHNSON, G.D. & HOLBOROW, E.J. Immunofluorescence. In: WEIR, D.M. (ed.) Handbook of e·xperimental immunology. 2'h ed. Oxíord. Blackwell, 1973. p. 18.1-18.20.
6. KHOURY, E.L.; COSSIO, P.M.; SZARFMAN, A.; MARCOS, J.C.; MORTE 0, O.G. & ARANA, R.M. Immunofluorescent vascular pattern due to EVI antibody of Chagas' disease. Am. J. clni. Path., 69: 62-5, 1978.
7. PAES, R.A.P.; UEDA, M. & GORDINHO, R.S. - Anticorpos anti-reticulina na esquistossomose crônica. Rev. Inst. Adolfo Lutz, 39: 121-5, 1979.
8. RIZZETTO, G.D. & DONIACH, D. - Types of "reticulin" antibodies de tected in human sera by immunofluorescence. J. clin. Path., 26: 841-51, 1973.
9. SEAH, P.P.; FRY, L. HOFFBRAND, A.V. & HOLBOROW, E.J. - Tissue antibodies in dermatitis herpetiformis and adult coeliae disease. Lancei, 1: 834-6, 1971.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 1982 Instituto Adolfo Lutz Journal