Keywords
a and B-asarone, toxic effect in mice and chick embryos
a and B3-asarone, mutagenic activity in Salmonella typhimurium
calamus oil, toxic effect in mice and chick embryos
calamus oil, mutagenic activity in S. typhimurium
a and B3-asarone, mutagenic activity in Salmonella typhimurium
calamus oil, toxic effect in mice and chick embryos
calamus oil, mutagenic activity in S. typhimurium
How to Cite
1.
Yabiku HY, Oga S, Lajolo F, Andrighetti H. Toxicity of α and β-asarone, and calamus oil for mice, chick embryos, and mutagenicity for Salmonella typhimurium. Rev Inst Adolfo Lutz [Internet]. 1985 Dec. 30 [cited 2024 Jul. 3];45(1-2):1-12. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/36843
Abstract
The LD50 was 154.5 mg per kg of mice injected intraperitoneally with calamus oil obtained from the Indian variety, while oil from the European varíety had unmeasureable toxicity. The LD50 was 184.0 mg/kg for p-asarone and 226.0 mg/kg for a-asarone. There was no teratogenic activity in chick embryos injected with either calamus oil (Indian or European variety) or a-asarone. Mean mortality varied from 10 to 100%. Ames test showed no mutagenic activity when p-asar,one was added, at concentrations of 10, 50, 100, 200 or 500 mcg to plates growing Salmonella typhimurium. The activator factor present in líver extracts from rats after induction with Aroclor 1254 did not influence the lack of mutagenicity.
References
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17. WOJTOWICZ, E.J. - Spectrofluorometric determination of B3-asarone in sweet and dry vermouths. J. agric. Food Chem., 24: 526-8, 1976.
18. YABIKU, H.Y.; OGA, S. & LAJOLO, F.M. - Efeitos tóxicos do óleo de Acorus calamus. Estudo preliminar em ratos e embriões de galinha. An. Farm. Quím. São Paulo, 19: 252-8, 1979.
19. YABIKU, H.Y. & LAJOLO, F. - Determinação de B-asarona em bebidas alcoólicas. Rev. Inst. Adolfo Lutz, 40:135-45, 1980.
2. CAVAZZA, G. - Les chimiotypes parmi Ies plantes aromatiques cas du calamus polyploid. A nn. Falsif. Expert. Chim., 69,' 833-44, 1976.
3. CHOPRA, I.C.; KHAJURIA, B.N. & CHOPRA, C.L. - Antibacterial properties of volatile principIes from Alpinia galanga and Acorus calamus. Antibiot. Chemother., 7:378-83, 1957.
4. COUNCIL OF EUROPE - Natural [lavouring substances, their sources, and added artificial flavouring substances. Strasburg, 1974. p. 34.
5. DANDIYA, P.C.; BAXTER, R.M.; WALKER, G.C. & CULLUMBINE, H. - Studies on
Acorus ealamu«, part lI: investigation of volatile oil. J. Pharm. Pharmacol., 11: 163·8, 1959.
6. DANDIYA, P.C. & CULLUMBINE, H. Studies on Acorus calamus. III. Some
pharmacological actions of the volatile oil. J. Pharmacol. exp. Ther., 125 :353-9, 1959.
7. ESTADOS UNIDOS. National Institute for Occupational Safety and Health. Registery of toxic effects o] chemical substances. Is.1.1 1977. v. 2, p. 166.
8. GOGGELMANN, W. & SCHIMMER, O. Mutagenicity testing of B-asarone and commercial calamus drugs with Salmonella typhimurium. Mutat. Ree., 121: 191-4, 1983.
9. GRANER, E.A. - Estatística. 2.a ed. São Paulo, Melhoramentos, 19€6. p. 92-3.
10. HSIA, M.R.S.; ADAMOVICS, J.A. & KREAMER, B.L. - Microbiological mutagenicity studies of insect growth regulators and other potencial insecticídal compounds in Salmonella typhimurium. Chernosphere, 8: 521-9, 1979, apud Chem. Abstr., 91: 187657p, 1979.
11. The MERCK index: an encyclopedia of chemicals and drugs. 9th ed. Rahway, N.J., Merck Co., 1976. p. 110.
12. MILLER, L.C. & TAINTER, M.L. - Estimation of the ED50 and its error by
means of logarithmic-probit graph paper. Proc, Soc. exp. Biol. Med., 57:261-4, 1944.
13. OGA, S. - Atividade teratogênica dos cloretos de samário e gadolínico em embrião de galinha. Rev. Fac, Farm. Bioquím. Univ. S. Paulo, 7:259-84, 1969.
14. SHARMA, J.D. & DANDIYA, P.C. - Studies on Acorus calamus. VI. Pharmacological actions of asarone and t3-asarone on cardiovascular system and smooth muscles. lndian J. med. Res., 50:61-5, 1962.
15. SOKAL, R.R. & ROHLF, F.J. - Biochemistry. San Francisco, W.H. Freeman, 1969. 776 p.
16. TAYLOR, J.M.; JONES, W.I.; HAGAN, E.C.; GROSS, M.A.; DAVIS, D.A. & COOK, E.L. - Toxicity of oil of calamus (Jammu variety). Toxicol. appl. Pharmacol., 10:
405, 1967.
17. WOJTOWICZ, E.J. - Spectrofluorometric determination of B3-asarone in sweet and dry vermouths. J. agric. Food Chem., 24: 526-8, 1976.
18. YABIKU, H.Y.; OGA, S. & LAJOLO, F.M. - Efeitos tóxicos do óleo de Acorus calamus. Estudo preliminar em ratos e embriões de galinha. An. Farm. Quím. São Paulo, 19: 252-8, 1979.
19. YABIKU, H.Y. & LAJOLO, F. - Determinação de B-asarona em bebidas alcoólicas. Rev. Inst. Adolfo Lutz, 40:135-45, 1980.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 1985 Instituto Adolfo Lutz Journal
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