Palavras-chave
receptor insulínico
substrato do receptor insulínico (IRSs)
sinalização intracelular
sítios tirosinafosforilados
Como Citar
Resumo
Os esforços de muitos laboratórios têm concentrado no desenvolvimento de pesquisas e na descoberta de vias moleculares que atuam na mediação da resposta pleiotrópica da insulina. Os estudos sobre o mecanismo de ação insulínico levaram a descoberta do receptor tirosina quinase e várias proteínas ligantes que são diretamente ativadas por meio de sítios de tirosinas fosforiladas existentes nesses receptores. A família dos substratos do receptor de insulina (IRSs) são as principais proteínas envolvidas na transdução do sinal intracelular desencadeado pela insulina as quais são encontradas em uma grande variedade de células e tecidos. Esse trabalho de revisão versa sobre o tema referente ao complexo do receptor de insulina e a cascata de sinalização induzida por esse hormônio.Referências
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Copyright (c) 2006 Adriana Luchs