Palavras-chave
Leprosy
HLA
Lepromin
Mycobacterium leprae
HLA
Lepromin
Mycobacterium leprae
Como Citar
1.
Souza FC de, Marcos EVC, Ura S, Nogueira MES. Identification of HLA-DQB1*01 alleles in mitsuda negative leprosy patients. Hansen. Int. [Internet]. 30º de junho de 2010 [citado 4º de novembro de 2024];35(1):41-4. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/35121
Resumo
The purpose of this study was to identify the gene encoding HLA-DQ1 involved in the absence of cellular immune response in 60 Mitsuda negative leprosy patients (50LL and 10BL). The results showed the presence of HLA-DQB1*0501 in 48.30% of patients, followed by HLA-DQB1*0602 in 31.66%, both subtypes of the phenotype HLA-DQB1*01. Despite the prevalence of these alleles, we can not say that they are responsible for the lack of response to the Mitsuda antigen. We suggest further studies to confirm the results.
Referências
1 Opromolla DVA. Manifestações Clínicas e Reações. In: Noções de Hansenologia. 2a edição, Centro de Estudos “Dr. Reynaldo Quagliato”. Instituto Lauro de Souza Lima, Bauru, p.51-58, 2000.
2 Beiguelman B. A reação de Mitsuda oitenta anos depois. Hansenologia Internationalis 24(2): 144-161, 1999.
3 Memória Association International de la Lepra. In: Congresso Internacional de Leprologia 6, Madrid p.1344, 1953.
4 Mitsuda K. On the value of a skin reaction to a suspension of leprous nodules. International Journal of Leprosy 21:347-58, 1953.
5 Ridley DS, Jopling WH. Classification of Leprosy According to Immunity. A five- group system. Int J Leprosy 1966; 34(3):255-73.
6 Ministério da Saúde. Secretaria de Políticas de Saúde. Guia para Utilização de Medicamentos e Imunobiológicos na área de Hanseníase. Centro de Documentação do Ministério da Saúde, Brasília,2000.
7 Brasil. Ministério da Saúde. Guia para controle da Hanseníase. 2ed. Brasília, 1984.
8 Brasil. Ministério da Saúde. Secretaria de Políticas de Saúde. Departamento de Atenção Básica. Guia para controle da Hanseníase. Ministério da Saúde. 1 ed. 2002. Brasília.
9 Hastings RC, Gillis TP, Krahenbuhl JL et al. Leprosy. Clin Mi- Leprosy. Clin Microbiol Rev, 1988; 1: 330–348
10 Rotberg, A. Some aspects of immunity on leprosy and their importance in epidemiology, pathogenesis and classification of forms of the disease. Based on 1529 lepromin-tested cases. Rev. Brás. Lepr.1937; 5:45-97.
11 Convit J, Pinardi ME, Rojas FA. Some considerations regardings the immunology of leprosy. Int J Leprosy 1971; 39(2):556-64.
12 Rea TH, Quismorio FP, Harding B, Nies KM, Di Saia PJ, Levan NE, et al. Immunologic responses in pacients with lepromatous leprosy. Arch Dermatol. 1976; 112(6): 791-800.
13 Nogueira MES, Vilani-Moreno FR, Silva EA, Arruda MSP. Imunologia. In: Noções de Hansenologia. 2ed. Bauru: Centro de Estudos “Dr Reynaldo Quagliato”. Instituto Lauro de Souza Lima, 2000. p. 27-42.
14 Abbas AK, Linchtman AH, Pober JS. Cellular and Molecular Immunology. 4rd edição,W.B. Saunders Company, Philadelphia, 2000.
15 Roy S, MC Guire W, Mascie-Taylor CG. Tumor necrosis factor promoter polymorphism and susceptibility to lepromatous leprosy. Journal of Infections and Diseases 176:530-2,1997.
16 Ottenhoff THM. Immunology of leprosy. New developments. Tropical and geographical medicine 46(2):72-80,1994.
17 Petzel-Erler ML. Genetics of the immune response and disease susceptibility. Cienc Cult (São Paulo) 1999; 51: 199-211.
18 Strachan T. Molecular genetics and polimorphism of class I HLA antigens. Br Med Bull 1987; 43(1):1-14.
19 Izumi S, Sugiyama K, Matsumoto Y, Ohkawa S. Analysis of the immunogenetic background of Japanese leprosy patients by the HLA system. Vox sang 42(5): 243-247, 1982.
20 Marcos EVC, Souza FC, Ura S, Opromolla DVA. Estudo de associação entre antígenos HLA e reação hansênica tipo 1 ulcerada. Anais Brasileiros de Dermatologia 75(3): 283-290, 2000.
21 Ottenhoff THM, Gonzalez NM, De Vries RR, ConvitJ, Van Rood JJ. Association of HLA specificity LB-E12 (MB1, DC1, MT1) with lepromatous leprosy in a Venezuelan population. Tissue antigens 24 (1): 25-29,1984.
22 Van Eden W, de Vries RR, D´Amaro J, Schreuder I, Leiker DL, Van Rood JJ. HLA-DR associated genetic control of the type of leprosy in a population from Surinam. Human immunology 4(4):343-50,1982.
23 Van Eden W, Mehra NK, Vaidya MC, D´Amarco J, Schreuder GMTh, Van Rood JJ. HLA and sporadic tuberculoid leprosy: a population study in Maharashta, India. Tissue antigens 18(3): 189-94,1981.
24 Visentainer JEL, Tsuneto LT, Serra MF, Peixoto PR, Petzel-Erler ML. Association of leprosy with HLA-DR2 in a Southern Brazilian population. Brazilian journal of medical and biological research 30(1): 51-9, 1997.
25 Souza FC, Marcos EVC, Ura S, Opromolla PA, Nogueira MES. Estudo comparativo entre reação de Mitsuda e antígenos
leucocitários humanos em pacientes hansenianos. Rev Soc Bras Med Trop 40 (2):188-191, 2007.
26 Marsh SGE, Albert ED, Bodmer WF, Bontrop B, Dupont H, Erlich HA,et. Al. Nomenclature for the factors of HLA system, 2010.Tissue Antigens 75, 291-455, 2010.
27 Miller SA, Dykes DD, Polesky HF. A simple salting out pro- A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic acids res 16:1215, 1988.
28 Excoffier L, Laval G, Schneider S: Arlequin ver. 3.0: An integrated software package for population genetics data analysis. Evolutionary Bioinformatics Online 2005, 1:47-50.
29 Allele * Frequencies in Worldwide Populations. Disponível em: http://www.allelefrequencies.net/default.asp. Acesso em 16 de setembro de 2009.
2 Beiguelman B. A reação de Mitsuda oitenta anos depois. Hansenologia Internationalis 24(2): 144-161, 1999.
3 Memória Association International de la Lepra. In: Congresso Internacional de Leprologia 6, Madrid p.1344, 1953.
4 Mitsuda K. On the value of a skin reaction to a suspension of leprous nodules. International Journal of Leprosy 21:347-58, 1953.
5 Ridley DS, Jopling WH. Classification of Leprosy According to Immunity. A five- group system. Int J Leprosy 1966; 34(3):255-73.
6 Ministério da Saúde. Secretaria de Políticas de Saúde. Guia para Utilização de Medicamentos e Imunobiológicos na área de Hanseníase. Centro de Documentação do Ministério da Saúde, Brasília,2000.
7 Brasil. Ministério da Saúde. Guia para controle da Hanseníase. 2ed. Brasília, 1984.
8 Brasil. Ministério da Saúde. Secretaria de Políticas de Saúde. Departamento de Atenção Básica. Guia para controle da Hanseníase. Ministério da Saúde. 1 ed. 2002. Brasília.
9 Hastings RC, Gillis TP, Krahenbuhl JL et al. Leprosy. Clin Mi- Leprosy. Clin Microbiol Rev, 1988; 1: 330–348
10 Rotberg, A. Some aspects of immunity on leprosy and their importance in epidemiology, pathogenesis and classification of forms of the disease. Based on 1529 lepromin-tested cases. Rev. Brás. Lepr.1937; 5:45-97.
11 Convit J, Pinardi ME, Rojas FA. Some considerations regardings the immunology of leprosy. Int J Leprosy 1971; 39(2):556-64.
12 Rea TH, Quismorio FP, Harding B, Nies KM, Di Saia PJ, Levan NE, et al. Immunologic responses in pacients with lepromatous leprosy. Arch Dermatol. 1976; 112(6): 791-800.
13 Nogueira MES, Vilani-Moreno FR, Silva EA, Arruda MSP. Imunologia. In: Noções de Hansenologia. 2ed. Bauru: Centro de Estudos “Dr Reynaldo Quagliato”. Instituto Lauro de Souza Lima, 2000. p. 27-42.
14 Abbas AK, Linchtman AH, Pober JS. Cellular and Molecular Immunology. 4rd edição,W.B. Saunders Company, Philadelphia, 2000.
15 Roy S, MC Guire W, Mascie-Taylor CG. Tumor necrosis factor promoter polymorphism and susceptibility to lepromatous leprosy. Journal of Infections and Diseases 176:530-2,1997.
16 Ottenhoff THM. Immunology of leprosy. New developments. Tropical and geographical medicine 46(2):72-80,1994.
17 Petzel-Erler ML. Genetics of the immune response and disease susceptibility. Cienc Cult (São Paulo) 1999; 51: 199-211.
18 Strachan T. Molecular genetics and polimorphism of class I HLA antigens. Br Med Bull 1987; 43(1):1-14.
19 Izumi S, Sugiyama K, Matsumoto Y, Ohkawa S. Analysis of the immunogenetic background of Japanese leprosy patients by the HLA system. Vox sang 42(5): 243-247, 1982.
20 Marcos EVC, Souza FC, Ura S, Opromolla DVA. Estudo de associação entre antígenos HLA e reação hansênica tipo 1 ulcerada. Anais Brasileiros de Dermatologia 75(3): 283-290, 2000.
21 Ottenhoff THM, Gonzalez NM, De Vries RR, ConvitJ, Van Rood JJ. Association of HLA specificity LB-E12 (MB1, DC1, MT1) with lepromatous leprosy in a Venezuelan population. Tissue antigens 24 (1): 25-29,1984.
22 Van Eden W, de Vries RR, D´Amaro J, Schreuder I, Leiker DL, Van Rood JJ. HLA-DR associated genetic control of the type of leprosy in a population from Surinam. Human immunology 4(4):343-50,1982.
23 Van Eden W, Mehra NK, Vaidya MC, D´Amarco J, Schreuder GMTh, Van Rood JJ. HLA and sporadic tuberculoid leprosy: a population study in Maharashta, India. Tissue antigens 18(3): 189-94,1981.
24 Visentainer JEL, Tsuneto LT, Serra MF, Peixoto PR, Petzel-Erler ML. Association of leprosy with HLA-DR2 in a Southern Brazilian population. Brazilian journal of medical and biological research 30(1): 51-9, 1997.
25 Souza FC, Marcos EVC, Ura S, Opromolla PA, Nogueira MES. Estudo comparativo entre reação de Mitsuda e antígenos
leucocitários humanos em pacientes hansenianos. Rev Soc Bras Med Trop 40 (2):188-191, 2007.
26 Marsh SGE, Albert ED, Bodmer WF, Bontrop B, Dupont H, Erlich HA,et. Al. Nomenclature for the factors of HLA system, 2010.Tissue Antigens 75, 291-455, 2010.
27 Miller SA, Dykes DD, Polesky HF. A simple salting out pro- A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic acids res 16:1215, 1988.
28 Excoffier L, Laval G, Schneider S: Arlequin ver. 3.0: An integrated software package for population genetics data analysis. Evolutionary Bioinformatics Online 2005, 1:47-50.
29 Allele * Frequencies in Worldwide Populations. Disponível em: http://www.allelefrequencies.net/default.asp. Acesso em 16 de setembro de 2009.
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