The efficacy and tolerability of rifampicin in Burmese patients with lepromatous leprosy

TIN SHWE; KYAW LWIN; KYO THWE

doi:10.47878/hi.1978.v3.35639

Autores

TIN SHWE M. B., B. S., D.P.T.M. (Regn.), D.C.T.M., Ph.D. (Lond.) Leprosy Hospital Htaukkyant, Rangoon, Burma.
KYAW LWIN M. B., B. S., D.P.H. Department of Health, Ministry of Health, Rangoon, Burma.
KYO THWE M. B., B. S.: F.R.C.P.E., D.T.M.. H. (Loud.). Department of Medicine, Institute of Medicine, Rangoon, Burma.

DOI:

https://doi.org/10.47878/hi.1978.v3.35639

Palavras-chave:

Virchowian hanseniasis, Therapy, Rifampicin

Resumo

Seventy-one Burmese adult patients with lepromatous leprosy were treated with various regimens of rifampicin monotherapy, 450 mg. daily for 60 days or 900 mg. once weekly for 12 weeks or 450 mg. daily for six months. Of the patients, 18 had relapsed after stopping DDS therapy, 20 were intolerant of DDS, 18 were DDS resistant and 15 had received no previous treatment. Rifampicin produced a 75% reduction in the size of skin nodules in two thirds of the patients and a complete disappearance of nodules in the others. After one month drug treatment the MI fell to zero but the BI remained unchanged. The once weekly regimen was as effective as the daily treatment. Four patients had to be withdrawn due to ENL reactions.

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Referências

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