Palavras-chave
Hanseníase
Mycobacterium leprae
Testes cutâneos
Lepromina
Antígeno de Mitsuda
Antígenos recombinantes
Mycobacterium leprae
Testes cutâneos
Lepromina
Antígeno de Mitsuda
Antígenos recombinantes
Como Citar
1.
Pinho JRR, Andrade Júnior HF de, Schenberg ACG. Os diferentes testes cutâneos existentes para acompanhamento de pacientes com hanseníase. Hansen. Int. [Internet]. 30º de novembro de 1998 [citado 15º de novembro de 2024];23(1/2):49-52. Disponível em: https://periodicos.saude.sp.gov.br/hansenologia/article/view/36464
Resumo
Testes cutâneos são utilizados para o acompanhamento de casos de hanseníase, pois constituem um dos parâmetros para a classificação da forma clínica da doença, prognóstico e mesmo para indicação e acompanhamento do tratamento. Estes testes foram desenvolvidos no início do século e utilizam suspensões de bacilos extraídos de lepromas humanos ou de tatus infectados. Neste artigo, revemos as características do teste da lepromina ou de Mitsuda e dos testes alternativos que foram desenvolvidos. Discutimos também o potencial da utilização de antígenos recombinantes como uma possibilidade futura para a obtenção de testes cutâneos mais específicos e mais padronizáveis em relação àqueles obtidos a partir de seres humanos ou de tatus.
Referências
1. CONVIT, J., PINARI, M.E., AVILA, J.L. et al. Specificity of the 48 hour reaction to the Mitsuda antigen. Bull. WHO, v.52: 187-191, 1975.
2. FERNANDEZ, J.M.M. The early reaction induced by lepromin. Int. J. Leprosy, v.8, p.1-14, 1940.
3. GILL, H.K. , MUSTAFA, A.S., GODAL, T. Vaccination of human volunteers with heat - killed M. leprae: local responses in relation to the interpretation of the lepromin reaction. Int. J. Leprosy, v. 56. p.36-44, 1988.
4. GUPTE, M.D., VALLISHAYEE, R.S., ANATHARAMAN, D.S. et al. Effect of skin test with M. leprae soluble antigen on reaction to a subsequent test with the same antigen. Int. J. Leprosy, v.60, p.54-60, 1992.
5. HASTINGS, R.C., GILLIS, T.P., KRAHENBUHL, J.L. et al. Leprosy. Clin. Microbial. Rev., v.1, p.330- 348, 1988.
6. HAYASHI, Y. On a pure culture of leprosy bacilli and skin reactions by means of the pure culture syspensions. Saikin-qaku Zasshi J. Bacteriol., v.272, p.51-53, 1918. Republicado em Int. J. Leprosy, v.21, p.370-372, 1953.
7. KOOIJ, R., GERRITSEN, T. Positive 'lepromin' reactions with suspensions of normal tissue particles. Int. J. Leprosy, v.24, p.71-181, 1956.
8. KOOIJ, R. The natur of the Mitsuda reaction. Leprosy Rev., v.30, p.137-139, 1959.
9. KUMAR, B., KAUR, S., SHARMA, V.K. et al. Lepromin-H versus lepromin-A. Ind. J. Leprosy, v.56, p.50-57, 1984.
10. LARA, C.B., NOLASCO, J.O. Self - healing, or abortive, and residual forms of childhood leprosy and their probable significance. Int. J. Leprosy, v. 24, p.245-263, 1956.
11. LEIKER, D.L. Studies on the lepromin test: I. influence of tha bacillary and tissue components in dilutions of lepromin. Int. J. Leprosy, v.29, p.157-167, 1961.
12. MEHRA, V.L., SALGAME, P., SNAPPER, S.B. et al. Vaccines against leprosy. In: PLATKIN, S.A., MORTIMER JR., E. A. eds. Vaccines. Philadelphia: WB Saunders, 1988.
13. MEYERS, W.M., KVERNES, S., BINFORD, C.H. Compar ison of react ions to human and armadillo lepromins in leprosy. Int. J. Leprosy, v.43, p.128-225, 1975.
14. MITSUDA, K. On the value of a skin reaction to a suspension of leprous nodules. Hifuka Hinyôka Zasshi. Japanese Journal of Dermatology and
Urology, v,19, p.697-708, 1919. Republicado e traduzido em: Int. I. Leprosy, v.21, p.347-358, 1953.
15. NEWELL, K.W. An epidemiologist's view of leprosy. Bull. WHO, v.34, p.827-857, 1966.
16.PESSOLANI, M.C.V., HUNTER, S.W., BRENNAN, R. Relat ionship between host histones and armadillo. derived Mycobacterium leprae. Int. J. Leprosy, v. 61, p.381-388, 1993.
17. PINTO, M.R.M., ERIYAGAMA, N.B., PEMAJAYANTHA, V. Immunological effects of lepromin testing in sri Lankan population groups. II. Effect on reactivity to a soluble protein antigen of Mycobacterium leprae. Leprosy Rev v.58, p.227-232, 1987.
18. PONNINGHAUS, J.M., FINE, P.E.M. Sensitization studies with potential leprosyvaccine preparations in Northern Malawi. Int. J. Leprosy, v.54, p.25-37, 1986.
19. REES, R.J.W. Progress in the preparation of an antileprosy vaccine from armadillo-derived Mycobacterium leprae. Int. I. Leprosy, v.51, p.515-518, 1983.
20. RIDLEY, D.S., JOPLING, W.B. Classification of leprosy according to immunity. A five group system. Int. J. Leprosy, v.34, p.255-273, 1966.
21. SENGUPTA, U. Studies on lepromin and soluble antigens of M. leprae: their classification, standardization and use. Indian. J. Leprosy, v.63. p.457-463, 1991.
22. SHEPARD, C.C., DRAPER, P., REES, R.J.W. et al. Effect of purification steps on the immunogenicity of Mycobacterium leprae. Br.J. Exp. Pathol., v.61, p. 376-379, 1980.
2 3 . SHEPARD, C.C., MINAGAWA, F., VAN LANDIGHAM, R.V. et al. Foot pad enlargement a s a me a s u r e o f i n d u c e d immu n i t y t o
Mycobacterium leprae. Int. J. Leprosy, v.48, p.371-381, 1980.
24. SHIELD, M.J., STANFORD, J.L., GARBAJOSA, G. et al. The epidemiological evaluation, in burma, of the skin test reagent LRA6; a cell free extract from armadillo derived Mycobacterium leprae. Part 1: leprosy patients. Int. J. Leprosy, v. 50, p.436-445, 1982.
25. SHIELD, M.J., STANFORD, J . L . The epidemiological evaluation, in burma, of the skin test reagent LRA6: a cell free extract from armadillo derived Mycobacterium leprae. Part 2: close contacts and non-contacts of bacilliferous leprosy patients. Int. J. Leprosy, v.50, p.446-454, 1982.
26. WADE, H.W. Induction of lepromin reactivity by repeated lepromin testing. Int. J. Leprosy, v.23, p. 310-315, 1955.
2 7 . WORLD HEALTH ORGANIZATION. Recommended safety requirements for the preparation of lepromin: a WHO memorandum. Bull. WHO, v.57, p.921-923, 1979.
28. WORLD HEALTH ORGANIZATION. Leprosy. In: __________ Tropical Diseases Research: Progress 1991 - 1992. Eleventh Programme Report of the UNDP/ World Bank/ WHO special Programme for Research and Training in Tropical Diseases (TDR). Geneva: 1993. p.47-55.
2. FERNANDEZ, J.M.M. The early reaction induced by lepromin. Int. J. Leprosy, v.8, p.1-14, 1940.
3. GILL, H.K. , MUSTAFA, A.S., GODAL, T. Vaccination of human volunteers with heat - killed M. leprae: local responses in relation to the interpretation of the lepromin reaction. Int. J. Leprosy, v. 56. p.36-44, 1988.
4. GUPTE, M.D., VALLISHAYEE, R.S., ANATHARAMAN, D.S. et al. Effect of skin test with M. leprae soluble antigen on reaction to a subsequent test with the same antigen. Int. J. Leprosy, v.60, p.54-60, 1992.
5. HASTINGS, R.C., GILLIS, T.P., KRAHENBUHL, J.L. et al. Leprosy. Clin. Microbial. Rev., v.1, p.330- 348, 1988.
6. HAYASHI, Y. On a pure culture of leprosy bacilli and skin reactions by means of the pure culture syspensions. Saikin-qaku Zasshi J. Bacteriol., v.272, p.51-53, 1918. Republicado em Int. J. Leprosy, v.21, p.370-372, 1953.
7. KOOIJ, R., GERRITSEN, T. Positive 'lepromin' reactions with suspensions of normal tissue particles. Int. J. Leprosy, v.24, p.71-181, 1956.
8. KOOIJ, R. The natur of the Mitsuda reaction. Leprosy Rev., v.30, p.137-139, 1959.
9. KUMAR, B., KAUR, S., SHARMA, V.K. et al. Lepromin-H versus lepromin-A. Ind. J. Leprosy, v.56, p.50-57, 1984.
10. LARA, C.B., NOLASCO, J.O. Self - healing, or abortive, and residual forms of childhood leprosy and their probable significance. Int. J. Leprosy, v. 24, p.245-263, 1956.
11. LEIKER, D.L. Studies on the lepromin test: I. influence of tha bacillary and tissue components in dilutions of lepromin. Int. J. Leprosy, v.29, p.157-167, 1961.
12. MEHRA, V.L., SALGAME, P., SNAPPER, S.B. et al. Vaccines against leprosy. In: PLATKIN, S.A., MORTIMER JR., E. A. eds. Vaccines. Philadelphia: WB Saunders, 1988.
13. MEYERS, W.M., KVERNES, S., BINFORD, C.H. Compar ison of react ions to human and armadillo lepromins in leprosy. Int. J. Leprosy, v.43, p.128-225, 1975.
14. MITSUDA, K. On the value of a skin reaction to a suspension of leprous nodules. Hifuka Hinyôka Zasshi. Japanese Journal of Dermatology and
Urology, v,19, p.697-708, 1919. Republicado e traduzido em: Int. I. Leprosy, v.21, p.347-358, 1953.
15. NEWELL, K.W. An epidemiologist's view of leprosy. Bull. WHO, v.34, p.827-857, 1966.
16.PESSOLANI, M.C.V., HUNTER, S.W., BRENNAN, R. Relat ionship between host histones and armadillo. derived Mycobacterium leprae. Int. J. Leprosy, v. 61, p.381-388, 1993.
17. PINTO, M.R.M., ERIYAGAMA, N.B., PEMAJAYANTHA, V. Immunological effects of lepromin testing in sri Lankan population groups. II. Effect on reactivity to a soluble protein antigen of Mycobacterium leprae. Leprosy Rev v.58, p.227-232, 1987.
18. PONNINGHAUS, J.M., FINE, P.E.M. Sensitization studies with potential leprosyvaccine preparations in Northern Malawi. Int. J. Leprosy, v.54, p.25-37, 1986.
19. REES, R.J.W. Progress in the preparation of an antileprosy vaccine from armadillo-derived Mycobacterium leprae. Int. I. Leprosy, v.51, p.515-518, 1983.
20. RIDLEY, D.S., JOPLING, W.B. Classification of leprosy according to immunity. A five group system. Int. J. Leprosy, v.34, p.255-273, 1966.
21. SENGUPTA, U. Studies on lepromin and soluble antigens of M. leprae: their classification, standardization and use. Indian. J. Leprosy, v.63. p.457-463, 1991.
22. SHEPARD, C.C., DRAPER, P., REES, R.J.W. et al. Effect of purification steps on the immunogenicity of Mycobacterium leprae. Br.J. Exp. Pathol., v.61, p. 376-379, 1980.
2 3 . SHEPARD, C.C., MINAGAWA, F., VAN LANDIGHAM, R.V. et al. Foot pad enlargement a s a me a s u r e o f i n d u c e d immu n i t y t o
Mycobacterium leprae. Int. J. Leprosy, v.48, p.371-381, 1980.
24. SHIELD, M.J., STANFORD, J.L., GARBAJOSA, G. et al. The epidemiological evaluation, in burma, of the skin test reagent LRA6; a cell free extract from armadillo derived Mycobacterium leprae. Part 1: leprosy patients. Int. J. Leprosy, v. 50, p.436-445, 1982.
25. SHIELD, M.J., STANFORD, J . L . The epidemiological evaluation, in burma, of the skin test reagent LRA6: a cell free extract from armadillo derived Mycobacterium leprae. Part 2: close contacts and non-contacts of bacilliferous leprosy patients. Int. J. Leprosy, v.50, p.446-454, 1982.
26. WADE, H.W. Induction of lepromin reactivity by repeated lepromin testing. Int. J. Leprosy, v.23, p. 310-315, 1955.
2 7 . WORLD HEALTH ORGANIZATION. Recommended safety requirements for the preparation of lepromin: a WHO memorandum. Bull. WHO, v.57, p.921-923, 1979.
28. WORLD HEALTH ORGANIZATION. Leprosy. In: __________ Tropical Diseases Research: Progress 1991 - 1992. Eleventh Programme Report of the UNDP/ World Bank/ WHO special Programme for Research and Training in Tropical Diseases (TDR). Geneva: 1993. p.47-55.
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