On the characteristics of buclizine dihydrochloride and its detection through spectrophotometric titration
Vol. 34 No. 1-2 (1974), ORIGINAL ARTICLE
Vol. 34 No. 1-2 (1974)

On the characteristics of buclizine dihydrochloride and its detection through spectrophotometric titration

ORIGINAL ARTICLE
https://doi.org/10.53393/rial.1974.34.37059
Published 1974-12-30
Waldomiro Pregnolatto
Instituto Adolfo Lutz
Narcildo Luiz Pissatto
Laboratil S. A. - Indústria Farmacêutica
pdf (Português (Brasil))

Keywords

buclizine dihydrocloride, characteristics
buclizine dihydrocloride, spectrophotometric determination in pharmaceuticals
pharmaceuticals, buclizine dihydrocloride

How to Cite

1.
Pregnolatto W, Pissatto NL. On the characteristics of buclizine dihydrochloride and its detection through spectrophotometric titration. Rev Inst Adolfo Lutz [Internet]. 1974 Dec. 30 [cited 2024 Jul. 3];34(1-2):69-77. Available from: https://periodicos.saude.sp.gov.br/RIAL/article/view/37059
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Abstract

Some characteristics of the buclizine dihydrochloride, a tranquilizer and anti-histaminic agent used in pharmaceuticals, are described in this work. Titration curves and absorption spectra of the plain substance are also shown herein. It is described as well a technic for detecting the substance, when free, through a simple titration with perchloric acid in a non-aqueous medium and violet crystal as indicator. Further it is described a technic for detecting the substance through spectrophotometric titration with or without previous purification by diethyl ether washing, and through thin-layer chromatography, with absorbance readings either at 239 nm
in chloroformic solution or at 274 nm, in benzene.

https://doi.org/10.53393/rial.1974.34.37059
pdf (Português (Brasil))

References

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Copyright (c) 1974 Instituto Adolfo Lutz Journal

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